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LEUROSINE
- CAS No.
- 23360-92-1
- Chemical Name:
- LEUROSINE
- Synonyms
- amotin;LEUROSINE;nsc-528004;Vinleurosine;Vincristine EP Impurity F;Vincristine EP Impurity F (Leurosine);4'-Deoxy-3',4'-epoxyvincaleucoblastine, 9CI;(3'R,4'S)-3',4'-Oxy-4'-deoxyvincaleukoblastine;Vincristine Impurity 6(Vincristine EP Impurity F);4′-deoxy-3′α,4′α-epoxyvincaleukoblastine(leurosine)
- CBNumber:
- CB4205283
- Molecular Formula:
- C46H56N4O9
- Molecular Weight:
- 808.97
- MDL Number:
- MFCD01716248
- MOL File:
- 23360-92-1.mol
- MSDS File:
- SDS
Last updated:2023-05-04 17:34:36
Melting point | 202-205℃ |
---|---|
Density | 1.39 |
pka | 11.36±0.60(Predicted) |
EWG's Food Scores | 1 |
FDA UNII | 803MS59U85 |
SAFETY
Risk and Safety Statements
RIDADR | 1544 |
---|---|
HazardClass | 6.1(a) |
PackingGroup | II |
Toxicity | dog,LDLo,intraperitoneal,12mg/kg (12mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA",Eksperimental'naya Onkologiya. Experimental Oncology. Vol. 9(5), Pg. 76, 1987. |
LEUROSINE Chemical Properties,Uses,Production
Description
Vinqa rosea yields this complex dimeric alkaloid which forms colourless crystals that are best purified by recrystallization from acetonitrile. It crystallizes with 8 moles of H20 and loses solvent when heated at In-5°C. It is also dextro? rotatory with [α]26D + n° (CHCI3)’ A crystalline SUlphate is known which has m.p. 238-242°C (dec.) and [α]D - 8.3° (MeOH). The N(b)-oxide is identical with pleurosine (q.v.).
Uses
Antineoplastic.
Uses
Vinleurosine is an antitumor compound derived from Vinca Rosea.
Definition
ChEBI: Leurosine is a vinca alkaloid.
References
Svoboda., J. Amer. Pharm. Assoc., 47,834 (1959)
Neuss et al., J. Amer. Chern. Soc., 81,4754 (1959)
Revised structure:
Neuss et al., Tetrahedron Lett., 783 (1968)
LEUROSINE Preparation Products And Raw materials
Raw materials
Preparation Products
LEUROSINE Suppliers
Global( 64)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14335 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29822 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34571 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
Hubei Moco Chemical Co., Ltd. | 18672515910 | 3001071511@qq.com | China | 10993 | 58 |
ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 18021 | 56 |
Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7887 | 56 |
Chengdu HuaXia Chemical Reagent Co. Ltd | 400-1166-196 13458535857 | cdhxsj@163.com | China | 13360 | 58 |
23360-92-1(LEUROSINE)Related Search:
VincristineM1
4'-Deoxy Vincristine
N-Desmethylvinblastine
Vinorelbine EP Impurity G
Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2-oxido-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-
4-Desacetyl Vinblastine
3',4'-Anhydrovinblastine
Vinorelbine EP Impurity H
Cophylline
desacetylnavelbine
1of4
Vinleurosine
4b-Acetoxy-3,4epoxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester
(3'R,4'S)-3',4'-Oxy-4'-deoxyvincaleukoblastine
(3'alpha,4'alpha)-4'-Deoxy-3',4'-epoxyvincaleukoblastine
4'-Deoxy-3',4'-epoxyvincaleucoblastine, 9CI
4’-deoxy-3’,4’-epoxy-,(3’-alpha,4’-alpha)-vincaleukoblastin
4’-deoxy-3’,4’-epoxy-,(3’alpha,4’alpha)-vincaleukoblastin
amotin
LEUROSINE
nsc-528004
Vincristine Impurity 6(Vincristine EP Impurity F)
Vincaleukoblastine,4'-deoxy-3',4'-epoxy-, (3'a,4'a)-
Vincaleukoblastine, 4'-deoxy-3',4'-epoxy-, (3'α,4'α)-
Vincristine EP Impurity F
Vinorelbine EP Impurity E/Leurosine/4b-Acetoxy-3,4epoxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester
Vincristine EP Impurity F (Leurosine)
4′-deoxy-3′α,4′α-epoxyvincaleukoblastine(leurosine)
methyl(3aR,4R,5S,5aR,10bR,13aR)-4-(acetyloxy)-3a-ethyl-9-[(1aS,11S,13S,13aR)-1a-ethyl-11-(methoxycarbonyl)-1a,4,5,10,11,12,13,13a-octahydro-2H-3,13-methano-oxireno[9,10]azacycloundecino[5,4-b]indol-11-yl]-5-hydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate(leurosine)
Vincristine EP Impurity F(Vinorelbine EP Impurity E)
23360-92-1
C46H58N4O13S