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Antihistamine Physicochemical properties Instruction Precaution Adverse reaction
Pizotifen structure
Chemical Name:
Litec;bc105;BC 105;PIZOTIFEN;Pizotifan;Pizotylene;Pizotyline;Pizotifenum;Sandomigram;Sandomigran
Molecular Formula:
Formula Weight:
MOL File:

Pizotifen Properties

Melting point:
storage temp. 
DMSO: ≥8mg/mL
pKa 6.95 (Uncertain)
CAS DataBase Reference
15574-96-6(CAS DataBase Reference)
NIST Chemistry Reference
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22-63
Safety Statements  26-37/39-36/37
WGK Germany  3
RTECS  TM7165000
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P281 Use personal protective equipment as required.

Pizotifen price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B9688 Pizotifen ≥98% (HPLC) 15574-96-6 10mg $76.7 2018-11-13 Buy
Sigma-Aldrich B9688 Pizotifen ≥98% (HPLC) 15574-96-6 50mg $302 2018-11-13 Buy
TCI Chemical P2344 Pizotifen >98.0%(HPLC) 15574-96-6 50mg $43 2018-11-22 Buy
TCI Chemical P2344 Pizotifen >98.0%(HPLC) 15574-96-6 200mg $125 2018-11-22 Buy

Pizotifen Chemical Properties,Uses,Production


Pizotyline is also referred to as pizotifene and pizotifen malate. It is a chemical synthetic antihistamine. Its chemical structure is similar to that of heptaidime and amitriptyline. It has a strong anti 5serotonin and antihistamine effect and weak anti acetylcholine action, which is one of the commonly used drugs to prevent migraine. This product also inhibits the analgesic effect of bradykinin (BK) on the peripheral nerve and its sedative and antidepressant effects. This product can reduce the tolerance to ethanol, and can strengthen the effect of diazepam, sedative and tricyclic antidepressant. It is clinically used in typical and atypical migraine. It can reduce symptoms, reduce the number of episodes and duration, and the effect is significant. But it has no immediate effect on the acute attack of migraine. It can be used in erythromelalgia, angioedema, chronic urticaria, skin scratch disease etc.. It has also been reported that pizotyline can be used for the treatment of the carcinoid syndrome caused diarrhea, facial flushing and carotid artery pain as well as polycythemia induced pruritus.

Physicochemical properties

It is white needle like crystal, odorless, with bitter taste. The melting point is 147.5 151.5 centigrade. It can dissolve in organic solvent or acid solution, such as ethanol, chloroform, etc., insoluble in water. Pizotyline is synthesized by the multistep reaction using 2chloromethyl thiophene as raw material. It's an analgesic and mainly used for the treatment of typical and atypical migraine. It can also be used for chronic urticaria, atrial and ventricular premature beat.



Adverse reaction

Chemical Properties

White to Off-White Solid


benzocycloheptane based drug


Serotonin antagonist structurally related to Cyproheptadine. Antimigraine; appetite stimulant.


ChEBI: A benzocycloheptathiophene that is 9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophene 4-ylidene)-1-methylpiperidine which is joined from the 4 position to the 4 position of an N-methylpiperidine moiety b a double bond. It is a sedating antihistamine, with strong serotonin antagonist and weak antimuscarinic activity. It is generally used as the malate salt for the treatment of migraine and the prevention of headache attacks during cluster periods.

brand name

Sandomigran (Novartis).

Pizotifen Preparation Products And Raw materials

Raw materials

Preparation Products

Pizotifen Suppliers

Global( 120)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
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0755-23311925 CHINA 3203 55
Mainchem Co., Ltd.
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J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
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021-67121385 China 24560 81
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418
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LGM Pharma 1-(800)-881-8210
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Chemsky(shanghai)International Co.,Ltd. 021-50135380 China 32365 50
XiaoGan ShenYuan ChemPharm co,ltd Tell:86-712-2580635 Mobile:15527768850 . 15527768836
86-712-2580625 QQ:1623551145 China 9103 52
Hangzhou Yuhao Chemical Technology Co., Ltd 0571-82693216
+86-571-82880190 China 9409 52

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