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Pizotifen

Antihistamine Physicochemical properties Instruction Precaution Adverse reaction
Pizotifen
Pizotifen structure
CAS No.
15574-96-6
Chemical Name:
Pizotifen
Synonyms
Litec;bc105;BC 105;PIZOTIFEN;Pizotifan;Pizotylene;Pizotyline;Pizotifenum;Sandomigram;Sandomigran
CBNumber:
CB4230373
Molecular Formula:
C19H21NS
Formula Weight:
295.44
MOL File:
15574-96-6.mol

Pizotifen Properties

Melting point:
140-142°C
storage temp. 
Refrigerator
solubility 
DMSO: ≥8mg/mL
pka
pKa 6.95 (Uncertain)
form 
powder
Merck 
14,7515
CAS DataBase Reference
15574-96-6(CAS DataBase Reference)
NIST Chemistry Reference
Pizotyline(15574-96-6)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22-63
Safety Statements  26-37/39-36/37
WGK Germany  3
RTECS  TM7165000
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P281 Use personal protective equipment as required.

Pizotifen price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B9688 Pizotifen ≥98% (HPLC) 15574-96-6 10mg $76.7 2018-11-13 Buy
Sigma-Aldrich B9688 Pizotifen ≥98% (HPLC) 15574-96-6 50mg $302 2018-11-13 Buy
TCI Chemical P2344 Pizotifen >98.0%(HPLC) 15574-96-6 50mg $43 2018-11-22 Buy
TCI Chemical P2344 Pizotifen >98.0%(HPLC) 15574-96-6 200mg $125 2018-11-22 Buy

Pizotifen Chemical Properties,Uses,Production

Antihistamine

Pizotyline is also referred to as pizotifene and pizotifen malate. It is a chemical synthetic antihistamine. Its chemical structure is similar to that of heptaidime and amitriptyline. It has a strong anti 5serotonin and antihistamine effect and weak anti acetylcholine action, which is one of the commonly used drugs to prevent migraine. This product also inhibits the analgesic effect of bradykinin (BK) on the peripheral nerve and its sedative and antidepressant effects. This product can reduce the tolerance to ethanol, and can strengthen the effect of diazepam, sedative and tricyclic antidepressant. It is clinically used in typical and atypical migraine. It can reduce symptoms, reduce the number of episodes and duration, and the effect is significant. But it has no immediate effect on the acute attack of migraine. It can be used in erythromelalgia, angioedema, chronic urticaria, skin scratch disease etc.. It has also been reported that pizotyline can be used for the treatment of the carcinoid syndrome caused diarrhea, facial flushing and carotid artery pain as well as polycythemia induced pruritus.

Physicochemical properties

It is white needle like crystal, odorless, with bitter taste. The melting point is 147.5 151.5 centigrade. It can dissolve in organic solvent or acid solution, such as ethanol, chloroform, etc., insoluble in water. Pizotyline is synthesized by the multistep reaction using 2chloromethyl thiophene as raw material. It's an analgesic and mainly used for the treatment of typical and atypical migraine. It can also be used for chronic urticaria, atrial and ventricular premature beat.

Instruction

Precaution

Adverse reaction

Chemical Properties

White to Off-White Solid

Uses

benzocycloheptane based drug

Uses

Serotonin antagonist structurally related to Cyproheptadine. Antimigraine; appetite stimulant.

Definition

ChEBI: A benzocycloheptathiophene that is 9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophene 4-ylidene)-1-methylpiperidine which is joined from the 4 position to the 4 position of an N-methylpiperidine moiety b a double bond. It is a sedating antihistamine, with strong serotonin antagonist and weak antimuscarinic activity. It is generally used as the malate salt for the treatment of migraine and the prevention of headache attacks during cluster periods.

brand name

Sandomigran (Novartis).

Pizotifen Preparation Products And Raw materials

Raw materials

Preparation Products


Pizotifen Suppliers

Global( 120)Suppliers
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Shenzhen Sendi Biotechnology Co.Ltd.
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