4H-Cyclopenta-1,3-dioxole, 4-[[(1,1-diMethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,4R,6aR)-
![4H-Cyclopenta-1,3-dioxole, 4-[[(1,1-diMethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,4R,6aR)- Structure](CAS/GIF/805245-41-4.gif)
- CAS No.
- 805245-41-4
- Chemical Name:
- 4H-Cyclopenta-1,3-dioxole, 4-[[(1,1-diMethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,4R,6aR)-
- Synonyms
- X-3117 int;RX-3117 int;(3R,4R,6aR)-tert-butyl-(5-fluoro-2,2-dimethyl-6-trityloxymet;4H-Cyclopenta-1,3-dioxole,4-[[(1,1-diMethylethyl)diphenylsil...;(3R,4R,6aR)-tert-butyl-(5-fluoro-2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yloxy)-diphenyl-silane;((3aR,4R,6aR)-5-fluoro-4,6a-dihydro-2,2-dimethyl-6-((trityloxy)methyl)-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)(tert-butyl)diphenylsilane;tert-butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane;tert-Butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane;(3aR,4R,6aR)-4-[[(1,1-Dimethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-dimethyl-6-[(triphenylmethoxy)methyl]-4H-cyclopenta-1,3-dioxole;4H-Cyclopenta-1,3-dioxole, 4-[[(1,1-diMethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,4R,6aR)-
- CBNumber:
- CB42627067
- Molecular Formula:
- C44H45FO4Si
- Molecular Weight:
- 684.91
- MDL Number:
- MOL File:
- 805245-41-4.mol
| Product description | Number | Pack Size | Price |
| CID86268842 | 3795EA | 100mg | $212 |
| tert-Butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane 95+% | A209064 | 1g | $267 |
| tert-Butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane 95+% | CD42000216 | 250mg | $269 |
| tert-Butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane | 805245414 | 250mg | $291.04 |
| tert-butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane 95% | CM137845 | 1g | $636 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
4H-Cyclopenta-1,3-dioxole, 4-[[(1,1-diMethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,4R,6aR)- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 3795EA | CID86268842 | 805245-41-4 | 100mg | $212 | 2021-12-16 | Buy |
| Ambeed | A209064 | tert-Butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane 95+% | 805245-41-4 | 1g | $267 | 2021-12-16 | Buy |
| Crysdot | CD42000216 | tert-Butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane 95+% | 805245-41-4 | 250mg | $269 | 2021-12-16 | Buy |
| Alichem | 805245414 | tert-Butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane | 805245-41-4 | 250mg | $291.04 | 2021-12-16 | Buy |
| Chemenu | CM137845 | tert-butyl(((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((trityloxy)methyl)-3a,6a-dihydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)diphenylsilane 95% | 805245-41-4 | 1g | $636 | 2021-12-16 | Buy |
4H-Cyclopenta-1,3-dioxole, 4-[[(1,1-diMethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,4R,6aR)- Chemical Properties,Uses,Production
Synthesis
![4H-Cyclopenta-1,3-dioxole, 4-[[(1,1-diMethylethyl)diphenylsilyl]oxy]-3a,6a-dihydro-5-iodo-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,4R,6aR)-](/CAS/GIF/805245-40-3.gif)
805245-40-3
![4H-Cyclopenta-1,3-dioxole, 4-[[(1,1-diMethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,4R,6aR)-](/CAS/GIF/805245-41-4.gif)
805245-41-4
The general procedure for the synthesis of (((3aR,4R,6aR)-5-fluoro-2,2-dimethyl-6-((tolylsulfonyloxy)methyl)-4,6a-dihydro-3aH-cyclopentadieno[d][1,3]dioxol-4-yl)oxy)diphenylsilanes from the compound (CAS: 805245-40-3) was carried out as follows: under the protection of nitrogen ( 3R,4R,6aR)-tert-butyl-(5-fluoro-2,2-dimethyl-6-tritylmethoxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxolen-4- yloxy)diphenylsilane (10, 11.66 g, 14.71 mmol) and N-fluorobenzenesulfonimide (5.566 g, 17.65 mmol) were dissolved in anhydrous tetrahydrofuran (100 mL) and cooled to -78 °C. n-Butyllithium (27.6 mL, 44.13 mmol, 1.6 M hexane solution) was slowly added and the reaction mixture was stirred for 1 hour at a maintained temperature of -78 °C. Upon completion of the reaction, the reaction was quenched with saturated ammonium chloride solution and subsequently extracted with ethyl acetate. The organic layers were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure. The crude product was purified by fast silica gel column chromatography (eluent: hexane/ethyl acetate = 6:1) to afford the target compound 11 (7.35 g, 73% yield) as a white solid.1H NMR (400 MHz, CDCl3) δ 7.81-7.17 (m, 25H), 4.94 (t, J=7.2 Hz, 1H), 4.35 (m, 1H), 4.25 (m, 1H), 4.25 (m, 1H). 4.25 (m, 1H), 3.89 (t, J=12.0 Hz, 1H), 3.77 (t, J=12.0 Hz, 1H), 1.42 (s, 3H), 1.38 (s, 3H), 1.08 (s, 9H).
References
[1] Patent: US2005/222185, 2005, A1. Location in patent: Page/Page column 7
[2] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 22, p. 5641 - 5644
[3] Nucleosides, Nucleotides and Nucleic Acids, 2005, vol. 24, # 5-7, p. 707 - 708
[4] Patent: WO2014/145807, 2014, A1. Location in patent: Page/Page column 9; 26; 27
[5] Patent: WO2014/145807, 2014, A1
4H-Cyclopenta-1,3-dioxole, 4-[[(1,1-diMethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,4R,6aR)- Preparation Products And Raw materials
4H-Cyclopenta-1,3-dioxole, 4-[[(1,1-diMethylethyl)diphenylsilyl]oxy]-5-fluoro-3a,6a-dihydro-2,2-diMethyl-6-[(triphenylMethoxy)Methyl]-, (3aR,4R,6aR)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 9985 | 58 |
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| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| BeiJing Hwrk Chemicals Limted | 0757-86329057 18934348241 | sales4.gd@hwrkchemical.com | China | 14063 | 55 |
| EnliPharma Technology Co., Ltd | 0551-66399836 18955197623 | sales@enlipharma.com | China | 1876 | 55 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9793 | 50 |
