AZ-505
- CAS No.
- 1035227-44-1
- Chemical Name:
- AZ-505
- Synonyms
- AZ-505;AZ-505 2TFA salt;AZ-505;AZ505;AZ 505;AZ505 (ditrifluoroacetate);N-cyclohexyl-3-((3,4-dichlorophenethyl)amino)-N-(2-((2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)amino)ethyl)propanamide bis(2,2,2-trifluoroacetate);N-Cyclohexyl-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-N-[2-[[2-(3,4-dihydro-5-hydroxy-3-oxo-2H-1,4-benzoxazin-8-yl)ethyl]amino]ethyl]propanamide 2,2,2-trifluoroacetate (1:2)
- CBNumber:
- CB42627355
- Molecular Formula:
- C31H39Cl2F3N4O6
- Molecular Weight:
- 691.57
- MDL Number:
- MOL File:
- 1035227-44-1.mol
AZ-505 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A808203 | AZ505ditrifluoroacetate | 1035227-44-1 | 2.5mg | $250 | 2021-12-16 | Buy |
| TRC | A808203 | AZ505ditrifluoroacetate | 1035227-44-1 | 5mg | $415 | 2021-12-16 | Buy |
| Apolloscientific | BISN0120 | AZ505 ditrifluoroacetate | 1035227-44-1 | 10mg | $432 | 2021-12-16 | Buy |
| ChemScene | CS-1734 | AZ505ditrifluoroacetate 99.99% | 1035227-44-1 | 50mg | $1188 | 2021-12-16 | Buy |
| ApexBio Technology | B1256 | AZ505ditrifluoroacetate | 1035227-44-1 | 25mg | $1335 | 2021-12-16 | Buy |
AZ-505 Chemical Properties,Uses,Production
Uses
AZ505 is a potent inhibitor of SMYD2, which plays an important role in epigenetic signalling. Inhibiition of SMYD2 also functions as an activator of the tumor suppressor proteins.
Biological Activity
az505 is a potent set and mynd domain-containing 2 protein (smyd2) inhibitor that selectively inhibits the enzymatic activity of smyd2 (ic50: 0.12 μm) over a variety of other protein lysine methyltransferases (ic50 > 83.3 μμ), including smyd3, dot1l, ezh2, glp, g9a and set7/9 [1].az505 contains three distinct moieties: the benzooxazinone group which interacts with the lysine-binding channel of smyd2; the cyclohexyl group which interacts with the core set and i-set domains of smyd2; and the dichlorophenethyl group which extends across the peptide binding groove of smyd2 [1].the x-ray crystallographic analysis has revealed that az505 binds into the peptide binding groove of smyd2 competing with the peptide substrates [1].
AZ-505 Preparation Products And Raw materials
Raw materials
Preparation Products
AZ-505 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| InvivoChem | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | 58 |
| Aladdin Scientific | 58 |
| Amadis Chemical Company Limited | 58 |
| Haoyuan Chemexpress Co., Ltd. | 61 |
| MedChemexpress LLC | 58 |
| LETOPHARM LIMITED | 58 |
| SPIRO PHARMA | 55 |
| BOC Sciences | 65 |