Telmisartan

Telmisartan price More Price(15)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR1855	Telmisartan Pharmaceutical Secondary Standard; Certified Reference Material	144701-48-4	500mg	$129	2017-11-08	Buy
Sigma-Aldrich	1643419	Telmisartan United States Pharmacopeia (USP) Reference Standard	144701-48-4	200mg	$348.4	2017-11-08	Buy
TCI Chemical	T2861	Telmisartan >98.0%(HPLC)(T)	144701-48-4	1g	$84	2017-12-01	Buy
TCI Chemical	T2861	Telmisartan >98.0%(HPLC)(T)	144701-48-4	5g	$293	2017-12-01	Buy
Alfa Aesar	J61441	Telmisartan, 99%	144701-48-4	1g	$181	2017-11-08	Buy

Telmisartan Chemical Properties,Uses,Production

Chemical Properties

White or off-white crystalline powder, odorless and tasteless. Soluble in chloroform, slightly soluble in methanol, very slightly soluble in acetone, practically insoluble in water. Slightly soluble in 0.1mol/L hydrochloric acid, soluble in 0.1mol/L sodium hydroxide.
Absorption coefficient（E1％1cm）：509～541

Mechanisms of Action

80mg of telmisartan for the human body will practically completely counter the high blood pressure caused by angiotension II. Effects will last for 24 and can still be detected within 48 hours. Blood pressure-lowering effects should gradually become apparent within 3 hours after the initial dose. If treatment is suddenly interrupted, blood pressure will return to the same level as before treatment in a matter of days, and there will be no rebound high blood pressure. In a clinical trial that compared two kinds of antihypertensive drugs, patients in the treatment group experienced lower rates of coughing than those in the group treated by angiotensin converting enzyme inhibitors.
Telmisartan has a half-life of 18～24 hours, and will take effect 1～4 hours after taken. Medicinal effects can last for as long as 35 hours, with a high (T/P) ratio and outstanding effects in controlling morning blood pressure. Thus, this medicine can effectively control blood pressure for 24 hours, and it meets the once-daily medicinal standard (40～80mg, qd).
Clinical effects and characteristics:

• Pharmacokinetics show: Rapid effects (0.3h), long duration (35.4h), little effect on heart rate when lowering blood pressure.
• Compared to Enalapril: Stronger antihypertensive effects than Enalapril; when both are used in combination with diuretics, Telmisartan still appears to be superior and results in a lower coughing rate.
• Compared to Lisinopril: More apparent antihypertensive effects (for both systolic and diastolic blood pressure), coughing rate for Telmisartan (16%) is drastically lower than that of Lisinopril (60%).
• Compared to Atenolol: Similar antihypertensive effects, lower rate of side effects (impotence and fatigue).
• Compared to Amlodipine: The Telmisartan group experienced noticeably lower heart rates four hours after ingestion and from six a.m. to twelve p.m.

Overall, Telmisartan has the following characteristics in comparison with other antihypertensive medicine: specific receptor effects, noticeable hypertensive effects, good diuretic effects, improvement of myocardial stenosis, safe usage, good tolerance, and convenient daily dosage.

Side Effects

In the placebo control experiment, the incidence rate of negative events for the Telmisartan group (41.4%) was similar to that of the placebo group (43.9%). Negative events were unrelated to dosage, sex, age, or race.
The following lists negative reactions were accumulated via the 5788 hypertensive patients that were treated with Telmisartan in the clinical trial.
Negative effects are categorized by incident rate as:
Very common (>1/10); common (>1/100, <1/10=); uncommon (>1/1000, <1/100=); rare (>1/10000, <1/1000=); very rare (<1/100000=)
Bodily reaction: Common: Back pain (e.g. sciatica), chest pain, flu-like symptoms, infection symptoms (e.g. urinary tract infection including cystitis). Uncommon: sight abnormality, sweating.
Central and peripheral nervous system: Common: vertigo.
Digestive system: Common: stomach pain, diarrhea, indigestion, gastrointestinal disorders. Rare: dry mouth, bloating.
Muscle skeletal system: Common: joint pain, leg cramps or leg pain, muscle pain. Rare: Tenosensitis symptoms.
Nervous system: Rare: anxiety.
Respiratory system: Common: upper respiratory tract infection, including pharyngitis and rhinitis.
Skin and accessory system: Common: Skin abnormalities such as eczema.
Additionally, since Telmisartan entered the market, there have been individual cases of erythema, itching, syncope, insomnia, depression, stomach discomfort, vomiting, hypotension, bradycardia, tachycardia, dyspnea, eosinophilia, thrombocytopenia, weakness, and reduced work efficiency. Similar to other angiotensin II receptor blockers, very few cases have reported vascular edema, nettles, and other negative reactions.
The laboratory found: compared to the placebo, the Telmisartan group occasionally exhibited lowered hemoglobin or raised uric acid. Any increase in serum creatinine or liver enzymes in the Telmisartan group was similar or lower than that of the placebo group.

Patent

Telmisartan was originally formulated by the German pharmaceutical company Boehringer Ingelheim; it earned the German patent EP502,314 in 1991, was first approved to enter the American market in November 1998, and then entered German, Philippines, Australian, Belgium, British, and other markets.

Chemical Properties

White or off white crystalline powder

Uses

cardiotonic

Uses

Telmisartan is an angiotensin II receptor antagonist.

Uses

anti-cancer agent

Uses

Used alone or in combination with other classes of antihypertensives for the treatment of hypertension. Also used in the treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes mellitus, as well as the treatment of congestive heart

Definition

ChEBI: A member of the class of benzimidazoles used widely in the treatment of hypertension.

Telmisartan Preparation Products And Raw materials

Raw materials

Preparation Products

Telmisartan Suppliers

Supplier	Tel	Fax	Email	Country	ProdList	Advantage
Jiangsu Zhongbang Pharmaceutical Co., Ltd.	025-87151996	025-87151996	zbsales@chinaredsun.com	CHINA	32	55
Capot Chemical Co.,Ltd.	+86 (0)571-855 867 18	+86 (0)571-858 647 95	sales@capotchem.com	China	19954	60
Shenzhen Sendi Biotechnology Co.Ltd.	0755-23311925 18102838259	0755-23311925	Abel@chembj.com	CHINA	3218	55
Henan DaKen Chemical CO.,LTD.	+86-371-55531817		inquiry@dakenchem.com	CHINA	22144	58
Henan Tianfu Chemical Co.,Ltd.	0371-55170693	0371-55170693	info@tianfuchem.com	CHINA	20803	55
Mainchem Co., Ltd.	+86-0592-6210733	+86-0592-6210733	sales@mainchem.com	CHINA	32765	55
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	025-85710122	sales1@fine-chemtech.com	CHINA	893	55
ATK CHEMICAL COMPANY LIMITED	+86 21 5161 9050/ 5187 7795	+86 21 5161 9052/ 5187 7796	ivan@atkchemical.com	CHINA	10714	60
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.	027-50664929 / 13971561712	027-50664927 / QQ: 3452835437	hubxys2001@163.com	China	2014	55
Zhuhai Beri Medical Technology Co., Ltd	+86（0756）8699 456	+86（0756）8699 456	sales@zhberi.com	China	134	58

144701-48-4(Telmisartan)Related Search:

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• TU-199
• TELMISARTAN
• PRITOR
• MICARDIS
• BIBR 277
• 144701-48-4
• 4'[(1,4'-DIMETHYL-2'-PROPYL[2,6'-BI-1H-BENZIMIDAZOL]-1'-YL)METHYL][1,1'-BIPHENYL]-2-CARBOXYLIC ACID
• 4'-[(1,4'-DIMETHYL-2'-PROPYL[2,6'-BI-H-BENZIMIDAZOL]-1'-YL)METHYL][1,1'-BIPHENYL]-2-CARBOXYLIC ACID
• 3-methoxy-8-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methyl sulfinyl]-2,7,9-triazabicyclo[4.3.0]nona-2,4,8,10-tetraene
• [1,1'-Biphenyl]-2-carboxylic acid, 4'-[(1,4'-dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-
• 4'-[[1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl]-methyl]-1,1'-biphenyl-2carboxylic acid,dimethylethyl ester
• Telmisaran
• Telmisartan99.5%
• TelmisartanC33H30N402
• C16H18N4O3S
• C33H30N4O2
• Micardis, Pritor, 4[(1,4Dimethyl-2propyl[2,6bi-H-benzimidazol]-1yl)methyl][1,1biphenyl]-2-carboxylic Acid,
• TIMETAZIDINE
• TIMISHATAN
• 4′-((2-n-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl)methyl)biphenyl-2-carbonsure
• 1447014-48-4
• Pharmaceutical material and intermeidates
• Active Pharmaceutical Ingredients
• C37H38N4O2
• 4'-[{1,4'-Dimethyl-2'-Propyl[2,6'-Bi-1H-Benzimiaszol]-1'yl}-Methyl}-1,1'-Biphenyl-2-Caroxylic Acid
• INTERMEDIATESOF
• Antihypertensive
• 4'-[{1,4'-Dimethyl-2'-Propyl[2,6'-Bi-1H-Benzimiaszol]-1'yl}-Methyl}-1,1'-Biphenyl-2-Caroxylic Acid Dimethyl Ethyl Ester
• Imidazoles
• (intermediates of telmisartan)
• 4''-(1,7''-DIMETHYL-2''-PROPYL-1H-[2,5'']BIBENZOIMIDAZOLYL-3''-YLMETHYL)-BIPHENYL-2-CARBOXYLIC ACID
• 4-chloromethyl-5-methyl-1,3-dioxol-2-tone
• Telmisartan
• 4'-(1,7'-Dimethyl-2'-propyl-1H-
• Hypertension
• Intermediates & Fine Chemicals
• Pharmaceuticals
• API's
• BIBR 277, 4μ[(1,4μ-Dimethyl-2μ-propyl[2,6μ-bi-1H-benzimidazol]-1μ-yl)methyl][1,1μ-biphenyl]-2-carboxylic acid
• C20H24N2O5SD4
• C33H27N4O2D3
• 4'-[[4-Methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl]methyl]-2-biphenylcarboxylic acid
• Telmisartan,4′[(1,4′-Dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl)methyl][1,1′-biphenyl]-2-carboxylic acid, BIBR 277
• 4'-[[1,4'-Dimethyl-2
• Other Products
• Telmisartan (150 mg)
• 2-(4-{[4-Methyl-6-(1-Methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]Methyl}phenyl)benzoic acid
• TelMisartan (Micardis)
• BIBR 277SE
• TelMisartan API
• Hypertension.
• 4'-[[4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic Acid
• 4'-((1,7'-DiMethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]iMidazol]-3'-yl)Methyl)-[1,1'-biphenyl]-2-carboxylic acid
• 4'-((1,7'-Dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-car
• CARADRIN
• Telmisartan Synonyms 4'[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid
• (1,1'-Biphenyl)-2-carboxylic acid, 4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-b
• 2-[4-[[4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl]methyl]phenyl]benzoic acid