6-Nitroveratraldehyde
- CAS No.
- 20357-25-9
- Chemical Name:
- 6-Nitroveratraldehyde
- Synonyms
- DMNB;NVAD;NVAD20357-25-9;ASISCHEM R27925;DNA-K Inhibitor;6-nitroveratrol;DNA-PK Inhibitor;TIMTEC-BB SBB000505;6-NITROVERATRALDEHYDE;6-Nitroveratrumaldehyd
- CBNumber:
- CB4275729
- Molecular Formula:
- C9H9NO5
- Molecular Weight:
- 211.17
- MDL Number:
- MFCD00007134
- MOL File:
- 20357-25-9.mol
- MSDS File:
- SDS
| Melting point | 131-133 °C (lit.) |
|---|---|
| Boiling point | 350.84°C (rough estimate) |
| Density | 1.4194 (rough estimate) |
| refractive index | 1.5700 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO: 22 mg/mL |
| form | solid |
| color | yellow |
| Water Solubility | Insoluble in water. Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO. |
| Sensitive | Air & Light Sensitive |
| BRN | 395599 |
| CAS DataBase Reference | 20357-25-9(CAS DataBase Reference) |
| FDA UNII | 3V2SVJ99E2 |
| NIST Chemistry Reference | 6-Nitroveratraldehyde(20357-25-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GY8410000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29130000 | |||||||||
| NFPA 704 |
|
6-Nitroveratraldehyde price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 279609 | 6-Nitroveratraldehyde technical grade, 80% | 20357-25-9 | 5g | $50.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | 260960 | DNA-PK Inhibitor | 20357-25-9 | 10mg | $130 | 2024-03-01 | Buy |
| TCI Chemical | N0538 | 6-Nitroveratraldehyde >85.0%(GC) | 20357-25-9 | 5g | $112 | 2024-03-01 | Buy |
| TCI Chemical | N0538 | 6-Nitroveratraldehyde >85.0%(GC) | 20357-25-9 | 25g | $447 | 2024-03-01 | Buy |
| Alfa Aesar | A14415 | 6-Nitroveratraldehyde, 96% | 20357-25-9 | 5g | $57.3 | 2024-03-01 | Buy |
6-Nitroveratraldehyde Chemical Properties,Uses,Production
Chemical Properties
yellow fluffy powder
Uses
6-Nitroveratraldehyde has been used in the preparation of no-carrier-added 6-18F-fluoro-L-dopa, fundamental tracer for cerebral positron emission tomography studies of dopaminergic system in humans and o-nitroaryl-bis(5-methylfur-2-yl)methanes, versatile synthons for the synthesis of nitrogen-containing heterocycles. DMNB is also an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair. It is also used for synthesizing analogs of alpha-asarone.
Definition
ChEBI: 4,5-dimethoxy-2-nitrobenzaldehyde is a C-nitro compound and an aromatic ether.
General Description
A cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) activity (IC50 = 15 μM) and DNA-PK-mediated double strand break (DSB) DNA repair by non-homologous DNA-end-joining (NHEJ). Reported to effectively sensitize cells to Cisplatin (Cat. No. 232120). Does not affect the activities of PKC or Chk2.
Biological Activity
Inhibitor of DNA-dependent protein kinase (DNA-PK) (IC 50 = 15 μ M), an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Displays 100-fold higher potency than its analog vanillin and does not affect PKC activity. Produces lethal effects on cisplatin-treated D5037 cells upon continuous exposure.
Biochem/physiol Actions
Cell permeable: yes
Purification Methods
The aldehyde is purified by dissolving 9g in 200mL of boiling 95% EtOH, and set aside overnight to crystallise. It is then dried in vacuo at 50o and recrystallised from 110mL of 95% EtOH to give 6-7g of aldehyde with m 132-133o. Crystallisation from aqueous EtOH provides light yellow needles. It is light sensitive and should be stored in the dark [Fetscher Org Synth Coll Vol 4 735 1963]. [Beilstein 8 H 262, 8 I 610, 8 II 290, 6 III 2065, 6 IV 1785.]
6-Nitroveratraldehyde Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7845 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4242 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
View Lastest Price from 6-Nitroveratraldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-12-26 | 6-Nitroveratraldehyde
20357-25-9
|
US $100.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-07-28 | 6-Nitroveratraldehyde
20357-25-9
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-02-11 | 6-Nitroveratraldehyde
20357-25-9
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Guanlang Biotechnology Co., Ltd. |
-
- 6-Nitroveratraldehyde
20357-25-9
- US $100.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 6-Nitroveratraldehyde
20357-25-9
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- 6-Nitroveratraldehyde
20357-25-9
- US $10.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.