CAY10703
- CAS No.
- 1841421-67-7
- Chemical Name:
- CAY10703
- Synonyms
- CAY10703;CAY10703,CAY-10703;Acetamide, N,N',N''-(nitrilotri-2,1-ethanediyl)tris[2,2-dichloro-;N,N',N''-(nitrilotris(ethane-2,1-diyl))tris(2,2-dichloroacetamide)
- CBNumber:
- CB43152586
- Molecular Formula:
- C12H18Cl6N4O3
- Molecular Weight:
- 479.01
- MDL Number:
- MFCD31735847
- MOL File:
- 1841421-67-7.mol
| Product description | Number | Pack Size | Price |
| CAY10703 ≥95% | 18911 | 1mg | $32 |
| CAY10703 ≥95% | 18911 | 5mg | $139 |
| CAY10703 ≥95% | 18911 | 10mg | $243 |
| CAY10703 ≥95% | 18911 | 25mg | $533 |
| N-[2-[Bis[2-[(2,2-dichloroacetyl)amino]ethyl]amino]ethyl]-2,2-dichloroacetamide | 7562EH | 10mg | $370 |
CAY10703 price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18911 | CAY10703 ≥95% | 1841421-67-7 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 18911 | CAY10703 ≥95% | 1841421-67-7 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 18911 | CAY10703 ≥95% | 1841421-67-7 | 10mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 18911 | CAY10703 ≥95% | 1841421-67-7 | 25mg | $533 | 2024-03-01 | Buy |
| AK Scientific | 7562EH | N-[2-[Bis[2-[(2,2-dichloroacetyl)amino]ethyl]amino]ethyl]-2,2-dichloroacetamide | 1841421-67-7 | 10mg | $370 | 2021-12-16 | Buy |
CAY10703 Chemical Properties,Uses,Production
Description
Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria.1,2 Inhibition of PDHK shifts cell metabolism from glycolysis to mitochondrial glucose oxidation, an effect that has relevance to cancer, type 2 diabetes, and other diseases.2,3 CAY10703 is a DCA trimer that is at least 10-fold more cytotoxic against leukemia cell lines than DCA.4 It is approximately 3-fold less cytotoxic than DCA against peripheral blood mononuclear cells from healthy blood donors. CAY10703 significantly reduces both basal and maximal respiration in leukemia cells.4 It is stable in vivo after subcutaneous inoculation, remaining in circulation for more than five hours after injection.4
Uses
Anticancer agent 254 (compound 10) is a dichloroacetic acid-loaded compound with enhanced antitumor activity against leukemia cells in vitro and better stability in vivo, and can be considered for preclinical evaluation of cancer inhibition.
References
1. Whitehouse, S., Cooper, R.H., and Randle, P.J. Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids Biochem. J. 141(3),761-774(1974).
2. Rodrigues, A.S., Correia, M., Gomes, A., et al. Dichloroacetate, the pyruvate dehydrogenase complex and the modulation of mESC pluripotency PLoS One 10(7),July 2015(2015).
3. Ruggieri, V., Agriesti, F., Scrima, R., et al. Dichloroacetate, a selective mitochondria-
4. Trapella, C., Voltan, R., Melloni, E., et al. Design, synthesis, and biological characterization of novel mitochondria targeted dichloroacetate-
CAY10703 Preparation Products And Raw materials
Raw materials
Preparation Products
CAY10703 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24961 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7982 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
