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GRUBBS CATALYST 2ND GENERATION

GRUBBS CATALYST 2ND GENERATION structure

CAS No.: 246047-72-3

Chemical Name:: GRUBBS CATALYST 2ND GENERATION

Synonyms: GRUBBS II;Grubbs 2nd;Grubbs catalyst II;Grubbs Gen 2nd;2nd generation Grubbs catalyst;(1,3-DiMesityliMidazolin-2-ylidene)(tricyclohexylphosphine)rutheniuM dichloride;Benzylidene(dichloro)(1,3-diMesityl-2-iMidazolidinylidene)rutheniuM - tricyclohexylphosphine (1:1);benzylidene-[1,3-bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene]-dichlororuthenium,tricyclohexylphosphane;(1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium;Grubbs G2

CBNumber:: CB4322469

Molecular Formula:: C46H65Cl2N2PRu

Molecular Weight:: 848.98

MDL Number:: MFCD03453237

MOL File:: 246047-72-3.mol

Last updated:2023-12-13 16:54:32

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GRUBBS CATALYST 2ND GENERATION Properties

Melting point	143.5-148.5 °C(lit.)
storage temp.	2-8°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly, Heated)
form	Solid
color	Brown to Very Dark Brown to Very Dark Red
InChIKey	FCDPQMAOJARMTG-UHFFFAOYSA-L
FDA UNII	6DHB6F3EXA
EPA Substance Registry System	Ruthenium, [1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(phenylmethylene)(tricyclohexylphosphine)-, (SP-5-41)- (246047-72-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS02
Signal word	Warning
Hazard statements	H228
Precautionary statements	P210-P240-P241-P280-P370+P378
Hazard Codes	F
Risk Statements	36/37/38-11
Safety Statements	26-36/37/39
RIDADR	1325
WGK Germany	3
F	10-23
HazardClass	4.1
PackingGroup	Ⅱ

GRUBBS CATALYST 2ND GENERATION price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	919764	Grubbs Catalyst® M204 ChemBeads	246047-72-3	250MG	$124	2024-03-01	Buy
Sigma-Aldrich	919764	Grubbs Catalyst® M204 ChemBeads	246047-72-3	1G	$311	2024-03-01	Buy
Sigma-Aldrich	569747	Grubbs Catalyst, 2nd Generation	246047-72-3	2g	$599	2024-03-01	Buy
Sigma-Aldrich	569747	Grubbs Catalyst, 2nd Generation	246047-72-3	10g	$2600	2024-03-01	Buy
Sigma-Aldrich	569747	Grubbs Catalyst, 2nd Generation	246047-72-3	100mg	$49.4	2024-03-01	Buy

Product number	Packaging	Price	Buy
919764	250MG	$124	Buy
919764	1G	$311	Buy
569747	2g	$599	Buy
569747	10g	$2600	Buy
569747	100mg	$49.4	Buy

GRUBBS CATALYST 2ND GENERATION Chemical Properties,Uses,Production

Description

Grubbs catalysts are a series of transition metal carbene complexes used as catalyst for olefin metathesis.1 The Grubbs catalysts are based on a ruthenium atom surrounded by five ligands: two neutral electron-donating entities (e.g., trialkylphosphines, N-heterocyclic carbenes), two monoanionic groups (e.g., halides), and one alkylidene moiety (e.g., unsubstituted and substituted methylidenes). L2X2Ru=CHR complexes (where L is a phosphine ligand) were discovered first and are referred to as the first-generation Grubbs catalyst. (L)(L’)X2Ru=CHR complexes (where L is a phosphine ligand and L’ a saturated N-heterocyclic carbene or NHC ligand) are referred to as the second-generation Grubbs catalysts.
The first-generation Grubbs catalysts show attractive functional-group tolerance and handling properties and have been widely used as highly efficient promoters for ring opening metathesis polymerizations, ring-closing metathesis reactions to make disubstituted olefins, ethenolysis (i.e., cleavage of the carbon–carbon double bond), cross-metathesis of terminal olefins, and the preparation of 1,3-dienes via enyne metathesis. These catalysts and analogues are still widely used in important processes, including the ethenolysis of feedstocks derived from bio-renewable seed oils and the manufacture of macrocyclic hepatitis C therapeutics. Nevertheless, the first-generation Grubbs catalysts show limitations with electron-poor and electron-rich double bonds as well as with sterically hindered systems. The second-generation Grubbs catalysts with excellent metathesis activity while retaining the handling characteristics and broad functional-group tolerance of the earlier Grubbs catalysts are thereby developed. At the same time, the second-generation catalysts are stable against moisture and air.

Reference

M. L. Crawley, B. M. Trost, Applications of Transition Metal Catalysis in Drug Discovery and Development, 2012, ISBN 978-0-470-63132-4

Chemical Properties

pink-brown to red-purple crystals or powder

Characteristics

Grubbs catalyst is a kind of coordination compound used in olefin metathesis reaction, and the ligand in it has a great influence on the catalytic performance and stability of the catalyst. Grubbs second-generation catalysts are more active than first-generation catalysts and have a wider substrate range, including sterically demanding or deactivated olefins such as 1,1-disubstituted olefins and α,β-non- Saturated carbonyl compounds.

Uses

Grubbs Catalyst^? M204 can be used as a catalyst for ring-closing metathesis (RCM), cross-metathesis, and ring-opening metathesis polymerization (ROMP). It is also used to synthesize trisubstituted olefins with excellent functional group tolerance and selectivity via cross-metathesis and ring closing metathesis reactions.
It can also be used as a catalyst:

To synthesize coumarins from phenolic compounds via RCM.
To cleave secondary (E)-allyl vic-diols to aldehydes.

Uses

suzuki reaction

GRUBBS CATALYST 2ND GENERATION synthesis

Synthesis of GRUBBS CATALYST 2ND GENERATION from 2,4,6-Trimethylaniline

GRUBBS CATALYST 2ND GENERATION Preparation Products And Raw materials

Raw materials

2,4,6-Trimethylaniline

Preparation Products

GRUBBS CATALYST 2ND GENERATION Suppliers

Global( 285)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
WinWin Chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	13854	58
PT CHEM GROUP LIMITED	+86-85511178 +86-85511178	peter68@ptchemgroup.com	China	35453	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	6710	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
AB PharmaTech,LLC	323-480-4688		United States	989	55

Supplier	Advantage
WinWin Chemical CO., Limited	58
PT CHEM GROUP LIMITED	58
Shanghai UCHEM Inc.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
AB PharmaTech,LLC	55

View Lastest Price from GRUBBS CATALYST 2ND GENERATION manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-26	Grubbs Catalyst 2nd Generation 246047-72-3	US $0.00 / KG	1KG	≥99%	100mt/year	Jinan Finer Chemical Co., Ltd
2024-02-23	Grubbs catalyst 2nd generation 246047-72-3	US $132.00-459.00 / g	5g	0.98	10kg	Shanghai UCHEM Inc.
2022-09-24	GRUBBS CATALYST 2ND GENERATION 246047-72-3	US $0.00 / kg	1kg	99%	1000kg	henan kanbei chemical co.,ltd

Grubbs Catalyst 2nd Generation
246047-72-3
US $0.00 / KG
≥99%
Jinan Finer Chemical Co., Ltd

Grubbs catalyst 2nd generation
246047-72-3
US $132.00-459.00 / g
0.98
Shanghai UCHEM Inc.

GRUBBS CATALYST 2ND GENERATION
246047-72-3
US $0.00 / kg
99%
henan kanbei chemical co.,ltd

GRUBBS CATALYST 2ND GENERATION Spectrum

GRUBBS CATALYST 2ND GENERATION(246047-72-3)¹HNMR GRUBBS CATALYST 2ND GENERATION(246047-72-3)³¹PNMR GRUBBS CATALYST 2ND GENERATION(246047-72-3)IR

246047-72-3(GRUBBS CATALYST 2ND GENERATION)Related Search:

1,3-BIS(2,4,6-TRIMETHYLPHENYL)-IMIDAZOLIDINIUM-CHLORIDE Hoveyda-Grubbs Catalyst 2nd Generation Dichloro(p-cymene)ruthenium(II) dimer Rhodium(II) acetate dimer Ruthenium(II) chloride mesitylene dimer

Tris(triphenylphosphine)rhodiu Rhodium(III) 2,4-pentanedionate Bis(tricyclohexylphosphine)nickel(II) chloride, 99% Ruthenium(III) chloride hydrate (1,5-CYCLOOCTADIENE)(PYRIDINE)(TRICYCLOHEXYLPHOSPHINE)IRIDIUM(I) HEXAFLUOROPHOSPHATE

DICHLORO-[1,3-BIS(DIISOPROPYLPHENYL)IMIDAZOLYLIDENE]-(3-CHLOROPYRIDYL)PALLADIUM(II) Dichloro[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene](benzylidene)bis(3-bromopyridine)ruthenium(II) DICHLORO(O-ISOPROPOXYPHENYLMETHYLENE)(TRICYCLOHEXYLPHOSPHINE)RUTHENIUM(II) Benzylidene-bis(tricyclohexylphosphine)dichlororuthenium Ruthenium

Tricyclohexyl phosphine GRUBBS CATALYST 2ND GENERATION Tricyclohexylphosphine[3-phenyl-1H-inden-1-ylidene][1,3-bis(2,4,6-triMethylphenyl)-4,5-dihydroiMidazol-2-ylidene]rutheniuM(II)

1of4

1,3-Bis-(2,4,6-trimethylphenyl)-2-(imidazolidinylidene)(dichlorophenylmethylene)(tricyclohexylphosphine)ruthenium, Benzylidene[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(tricyclohexylphosphine)ruthenium, (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium (1,3-BIS-(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE)DICHLORO(PHENYLMETHYLENE)(TRICYCLOHEXYLPHOSPHINE)RUTHENIUM RUTHENIUM,[1,3-BIS-(2,4,6-TRIMETHYLPHENYL)-2-IMIDAZOLIDINYLIDENE]DICHLORO (PHENYLMETHYLENE) (TRICYCLOHEXYLPHOSPHINE) Grubbs Catalyst, 2nd RutheniuM,[1,3-bis(2,4,6-triMethylphenyl)-2-iMidazolidinylidene]dichloro(phenylMethylene)(tricyclohexylphosphine)-,(SP-5-41)- Catalyst, 2nd Generation Tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene][benzylidene]rut Tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene][benzylidine]Ruthenium(IV)dichloride BENZYLIDENE[1,3-DIMESITYL-2-IMIDAZOL.]-C L2-(TRI-CHEX-P)-RU Tricyclohexylphosphine1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-yli GRUBBS CATALYST,2 ND GEN Grubbs Catalyst, 2nd Generation≥ 98% (NMR) (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium Benzylidene[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(tricyclohexylphosphine)ruthenium [1 Grubb's second generation catalyst,97% Grubbs Catalyst 2nd Generation,97+% Benzylidene[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene] dichloro(tricyclohexyl-phosphine) ruthenium (1,3-Bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium ,97% (1,3-Bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium ,95% Grubbs Catalyst, 2nd Generation,(1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium, 1,3-Bis-(2,4,6-trimethylphenyl)-2-(imidazolidinylidene 1,3-Bis-(2,4,6-trimethylphenyl)-2-(imidazolidinylidene)(dichlorophenylmethylene)(tricyclohexylphosphine)ruthenium, Benzylidene[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(tricyclohexylphosphine)ruthenium Grubbs2ndgenerationcatalyst [1,3-bis(2,4,6-triMethylphenyl)iMidazolidin-2-ylidene](phenylMethylidene)(tricyclohexyl-$l^{5}-phosphanyl)rutheniuMbis(yliuM) dichloride Grubbs Catalyst 2nd Generation Grubbs Grubb's II Catalyst Grubbs (2nd generation) Grubbs Catalyst, 2^nd Generation Grubb's second generation catalyst GRUBBS CATALYST 2ND GENERATION (SP-5-41)-[1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium Grubbs Catalyst(TM) 2nd Generation 1,3-Bis-(2,4,6-trimethylphenyl)-2-(imidazolidinylidene)(dichlorophenyl -methylene)(tricyclohexylphosphine)ruthenium (II) Tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-di... Oxychlorination of Ethylene with Copper Chloride Catalyst* Grubbs Gen 2nd Benzylidene(dichloro)(1,3-diMesityl-2-iMidazolidinylidene)rutheniuM - tricyclohexylphosphine (1:1) Grubbs catalyst II GRUBBS II (1,3-DiMesityliMidazolin-2-ylidene)(tricyclohexylphosphine)rutheniuM dichloride 2nd generation Grubbs catalyst (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium benzylidene-[1,3-bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene]-dichlororuthenium,tricyclohexylphosphane Grubbs 2nd (1,3-Dimesitylimidazolin-2-ylidene) Grubbs G2 [1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]-dichloro(benzylidene)(tricyclohexylphosphine)ruthenium(II) Grubbs Catalyst??M204 Validamine Impurity 3 [1,3-Bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene]-dic 246047-72-3 C46H65Cl2N2PRu Catalysis and Inorganic Chemistry Metathesis Catalysts Ru