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GRUBBS CATALYST 2ND GENERATION

Description Reference
GRUBBS CATALYST 2ND GENERATION
GRUBBS CATALYST 2ND GENERATION structure
CAS No.
246047-72-3
Chemical Name:
GRUBBS CATALYST 2ND GENERATION
Synonyms
GRUBBS II;Grubbs Gen 2nd;Grubbs catalyst II;Grubb's II Catalyst;Grubbs Catalyst, 2nd;Grubbs (2nd generation);GRUBBS CATALYST,2 ND GEN;Catalyst, 2nd Generation;Grubbs2ndgenerationcatalyst;2nd generation Grubbs catalyst
CBNumber:
CB4322469
Molecular Formula:
C46H65Cl2N2PRu
Formula Weight:
848.97
MOL File:
246047-72-3.mol

GRUBBS CATALYST 2ND GENERATION Properties

Melting point:
143.5-148.5 °C(lit.)
storage temp. 
2-8°C
InChIKey
FCDPQMAOJARMTG-UHFFFAOYSA-L
EPA Substance Registry System
Ruthenium, [1,3-bis(2,4,6-trimethylphenyl)- 2-imidazolidinylidene]dichloro( phenylmethylene)(tricyclohexylphosphine)-, (SP-5-41)-(246047-72-3)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  F
Risk Statements  36/37/38-11
Safety Statements  26-36/37/39
RIDADR  1325
WGK Germany  3
10-23
HazardClass  4.1
PackingGroup 
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H228 Flammable solid Flammable solids Category 1
Category 2
Danger
Warning
P210, P240,P241, P280, P370+P378
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

GRUBBS CATALYST 2ND GENERATION price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 569747 Grubbs Catalyst, 2nd Generation 246047-72-3 2g $568 2018-11-13 Buy
Sigma-Aldrich 569747 Grubbs Catalyst, 2nd Generation 246047-72-3 10g $1690 2018-11-13 Buy
Sigma-Aldrich 569747 Grubbs Catalyst, 2nd Generation 246047-72-3 100mg $65 2018-11-13 Buy
Sigma-Aldrich 569747 Grubbs Catalyst, 2nd Generation 246047-72-3 500mg $201 2018-11-13 Buy

GRUBBS CATALYST 2ND GENERATION Chemical Properties,Uses,Production

Description

Grubbs catalysts are a series of transition metal carbene complexes used as catalyst for olefin metathesis.1 The Grubbs catalysts are based on a ruthenium atom surrounded by five ligands: two neutral electron-donating entities (e.g., trialkylphosphines, N-heterocyclic carbenes), two monoanionic groups (e.g., halides), and one alkylidene moiety (e.g., unsubstituted and substituted methylidenes). L2X2Ru=CHR complexes (where L is a phosphine ligand) were discovered first and are referred to as the first-generation Grubbs catalyst. (L)(L’)X2Ru=CHR complexes (where L is a phosphine ligand and L’ a saturated N-heterocyclic carbene or NHC ligand) are referred to as the second-generation Grubbs catalysts.
The first-generation Grubbs catalysts show attractive functional-group tolerance and handling properties and have been widely used as highly efficient promoters for ring opening metathesis polymerizations, ring-closing metathesis reactions to make disubstituted olefins, ethenolysis (i.e., cleavage of the carbon–carbon double bond), cross-metathesis of terminal olefins, and the preparation of 1,3-dienes via enyne metathesis. These catalysts and analogues are still widely used in important processes, including the ethenolysis of feedstocks derived from bio-renewable seed oils and the manufacture of macrocyclic hepatitis C therapeutics. Nevertheless, the first-generation Grubbs catalysts show limitations with electron-poor and electron-rich double bonds as well as with sterically hindered systems. The second-generation Grubbs catalysts with excellent metathesis activity while retaining the handling characteristics and broad functional-group tolerance of the earlier Grubbs catalysts are thereby developed. At the same time, the second-generation catalysts are stable against moisture and air.

Reference

M. L. Crawley, B. M. Trost, Applications of Transition Metal Catalysis in Drug Discovery and Development, 2012, ISBN 978-0-470-63132-4

Chemical Properties

pink-brown to red-purple crystals or powder

Uses

suzuki reaction

GRUBBS CATALYST 2ND GENERATION Preparation Products And Raw materials

Raw materials

Preparation Products


GRUBBS CATALYST 2ND GENERATION Suppliers

Global( 168)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21967 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1367 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
AB PharmaTech,LLC
323-480-4688
323-480-4688 sales01@abpharmatechusa.com United States 990 55
Win-Win Chemical CO., Limited
0086-577-64498589
0086-577-56994596 sales@win-winchemical.com CHINA 998 58
Changzhou Ansciep Chemical Co., Ltd.
+86 519 86305871
+86 519 86305879 sales@ansciepchem.com CHINA 3111 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24001 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20095 58

View Lastest Price from GRUBBS CATALYST 2ND GENERATION manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-17 GRUBBS CATALYST 2ND GENERATION
246047-72-3
US $1.00 / KG 1G 98% 100KG career henan chemical co

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