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GRUBBS CATALYST 2ND GENERATION

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Products Intro: Product Name:Grubbs Catalyst 2nd Generation
CAS:246047-72-3
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
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Products Intro: Product Name:GRUBBS CATALYST 2ND GENERATION
CAS:246047-72-3
Purity:99% Package:100g,500g,1KG,10KG,100KG
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Products Intro: Product Name:246047-72-3
CAS:246047-72-3
Purity:0.99 Package:25KG,5KG;1KG;500G
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Products Intro: Product Name:Grubbs Catalyst 2nd Generation
CAS:246047-72-3
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Products Intro: Product Name:GRUBBS CATALYST 2ND GENERATION
CAS:246047-72-3
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG

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GRUBBS CATALYST 2ND GENERATION Basic information
Description Reference
Product Name:GRUBBS CATALYST 2ND GENERATION
Synonyms:Grubb's second generation catalyst,97%;Grubbs Catalyst 2nd Generation,97+%;Benzylidene[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene] dichloro(tricyclohexyl-phosphine) ruthenium;(1,3-Bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium ,97%;(1,3-Bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium ,95%;Grubbs Catalyst, 2nd Generation,(1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium, 1,3-Bis-(2,4,6-trimethylphenyl)-2-(imidazolidinylidene;1,3-Bis-(2,4,6-trimethylphenyl)-2-(imidazolidinylidene)(dichlorophenylmethylene)(tricyclohexylphosphine)ruthenium, Benzylidene[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(tricyclohexylphosphine)ruthenium;GRUBBS II
CAS:246047-72-3
MF:C46H65Cl2N2PRu
MW:848.97
EINECS:688-322-3
Product Categories:Ru
Mol File:246047-72-3.mol
GRUBBS CATALYST 2ND GENERATION Structure
GRUBBS CATALYST 2ND GENERATION Chemical Properties
Melting point 143.5-148.5 °C(lit.)
storage temp. 2-8°C
InChIKeyFCDPQMAOJARMTG-UHFFFAOYSA-L
EPA Substance Registry SystemRuthenium, [1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(phenylmethylene)(tricyclohexylphosphine)-, (SP-5-41)- (246047-72-3)
Safety Information
Hazard Codes F
Risk Statements 36/37/38-11
Safety Statements 26-36/37/39
RIDADR 1325
WGK Germany 3
10-23
HazardClass 4.1
PackingGroup 
MSDS Information
ProviderLanguage
SigmaAldrich English
GRUBBS CATALYST 2ND GENERATION Usage And Synthesis
DescriptionGrubbs catalysts are a series of transition metal carbene complexes used as catalyst for olefin metathesis.1 The Grubbs catalysts are based on a ruthenium atom surrounded by five ligands: two neutral electron-donating entities (e.g., trialkylphosphines, N-heterocyclic carbenes), two monoanionic groups (e.g., halides), and one alkylidene moiety (e.g., unsubstituted and substituted methylidenes). L2X2Ru=CHR complexes (where L is a phosphine ligand) were discovered first and are referred to as the first-generation Grubbs catalyst. (L)(L’)X2Ru=CHR complexes (where L is a phosphine ligand and L’ a saturated N-heterocyclic carbene or NHC ligand) are referred to as the second-generation Grubbs catalysts.
The first-generation Grubbs catalysts show attractive functional-group tolerance and handling properties and have been widely used as highly efficient promoters for ring opening metathesis polymerizations, ring-closing metathesis reactions to make disubstituted olefins, ethenolysis (i.e., cleavage of the carbon–carbon double bond), cross-metathesis of terminal olefins, and the preparation of 1,3-dienes via enyne metathesis. These catalysts and analogues are still widely used in important processes, including the ethenolysis of feedstocks derived from bio-renewable seed oils and the manufacture of macrocyclic hepatitis C therapeutics. Nevertheless, the first-generation Grubbs catalysts show limitations with electron-poor and electron-rich double bonds as well as with sterically hindered systems. The second-generation Grubbs catalysts with excellent metathesis activity while retaining the handling characteristics and broad functional-group tolerance of the earlier Grubbs catalysts are thereby developed. At the same time, the second-generation catalysts are stable against moisture and air.
ReferenceM. L. Crawley, B. M. Trost, Applications of Transition Metal Catalysis in Drug Discovery and Development, 2012, ISBN 978-0-470-63132-4
Chemical Propertiespink-brown to red-purple crystals or powder
Usessuzuki reaction
GRUBBS CATALYST 2ND GENERATION Preparation Products And Raw materials
Tag:GRUBBS CATALYST 2ND GENERATION(246047-72-3) Related Product Information
Dichloro(p-cymene)ruthenium(II) dimer Rhodium(II) acetate dimer Ruthenium(II) chloride mesitylene dimer Tris(triphenylphosphine)rhodiu Rhodium(III) 2,4-pentanedionate Bis(tricyclohexylphosphine)nickel(II) chloride, 99% Ruthenium(III) chloride (1,5-CYCLOOCTADIENE)(PYRIDINE)(TRICYCLOHEXYLPHOSPHINE)IRIDIUM(I) HEXAFLUOROPHOSPHATE DICHLORO-[1,3-BIS(DIISOPROPYLPHENYL)IMIDAZOLYLIDENE]-(3-CHLOROPYRIDYL)PALLADIUM(II) Dichloro[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene](benzylidene)bis(3-bromopyridine)ruthenium(II) DICHLORO(O-ISOPROPOXYPHENYLMETHYLENE)(TRICYCLOHEXYLPHOSPHINE)RUTHENIUM(II) Benzylidene-bis(tricyclohexylphosphine)dichlororuthenium Hoveyda-Grubbs Catalyst 2nd Generation 1,3-BIS(2,4,6-TRIMETHYLPHENYL)-IMIDAZOLIDINIUM-CHLORIDE Tricyclohexyl phosphine GRUBBS CATALYST 2ND GENERATION Tricyclohexylphosphine[3-phenyl-1H-inden-1-ylidene][1,3-bis(2,4,6-triMethylphenyl)-4,5-dihydroiMidazol-2-ylidene]rutheniuM(II) Ruthenium