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NIGERICIN SODIUM SALT

NIGERICIN SODIUM SALT
NIGERICIN SODIUM SALT structure
CAS No.
28380-24-7
Chemical Name:
NIGERICIN SODIUM SALT
Synonyms
x-464;Helix c;HELIXIN C;NIGERICIN;Aids003767;Aids-003767;AZALOMYCIN M;NIGERICIN NA;POLYETHERIN A;Antibiotic M 2
CBNumber:
CB4331016
Molecular Formula:
C40H67NaO11
Formula Weight:
746.94
MOL File:
28380-24-7.mol

NIGERICIN SODIUM SALT Properties

Melting point:
183.5-185°
alpha 
D24 +36.2° (c = 0.842 in CHCl3)
storage temp. 
2-8°C
solubility 
chloroform: 10 mg/mL, clear, colorless

SAFETY

Hazard Codes  T,Xi
Risk Statements  25-36/37/38
Safety Statements  26-36/37/39-45-36
RIDADR  UN 3462 6.1/PG 3
WGK Germany  3
RTECS  QT6840000
10
HazardClass  6.1(b)
PackingGroup  III
HS Code  29419090
Toxicity LD50 in mice (mg/kg): 10-15 i.p. (Shoji); also reported as 2.5 i.p. (Harned)

NIGERICIN SODIUM SALT price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy

NIGERICIN SODIUM SALT Chemical Properties,Uses,Production

Uses

Nigericin is a polyether antibiotic produced by Streptomyces, notably S. hygroscopicus, isolated in the 1950s. Its complex structure was finally elucidated in 1968. Nigericin is an ionophore, possessing very high affinity for monovalent cations such as Na+ and K+. Nigericin disrupts membrane potential and Golgi apparatus in mitochondria. Although nigericin can be isolated as the free acid (under acidic conditions), like most ionophores it is extracted into organic solvents and is most conveniently isolated as a salt. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumour cell lines and some viruses, including HIV. Nigericin is the most common member of the polyether class which are common false positives in in vitro screening bioassays using crude microbial extracts. They are thus important standards for dereplication.

Uses

Nigericin is a polyether antibiotic produced by Streptomyces, notably S. hygroscopicus, isolated in the 1950s. Its complex structure was finally elucidated in 1968. Nigericin is an ionophore, possessing very high affinity for monovalent cations such as Na+ and K+. Nigericin disrupts membrane potential and Golgi apparatus in mitochondria. Although nigericin can be isolated as the free acid (under acidic conditions), like most ionophores it is extracted into organic solvents and is most conveniently isolated as a salt. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumor cell lines and some viruses, including HIV. Nigericin is the most common member of the polyether class which are common false positives in in vitro screening bioassays using crude microbial extracts. They are thus important standards for dereplication.

Definition

ChEBI: A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.

NIGERICIN SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products


NIGERICIN SODIUM SALT Suppliers

Global( 47)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Fujian Kerui Pharmaceutical Co., Ltd. 15960103919
0591-83309157 fjkerui@gmail.com China 22 62
Raw material medicin reagent co.,Ltd 025-57798860
sales@njromanme.com China 4620 58
Shanghai Boyle Chemical Co., Ltd.
86-21-57758967 sales@boylechem.com China 2927 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32365 50
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 sale@aladdin-e.com China 24991 65
Nanjing Sunlida Biological Technology Co., Ltd. 025-58378339;025-57798810
025-57019371 sales@sunlidabio.com China 3823 55
ChemStrong Scientific Co.,Ltd 0755 66853366
0755 28363542 sales@chem-strong.com; China 15618 56
Chengdu HuaXia Chemical Reagent Co. Ltd 400-1166-196 18981987031
028-84555506 QQ:800101999 cdhxsj@163.com China 10039 60
Novachemistry +44 (0)208 191 7890
+44 (0)203 637 6965 info@novachemistry.com United Kingdom 3798 58

28380-24-7(NIGERICIN SODIUM SALT)Related Search:


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