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NIGERICIN SODIUM SALT

NIGERICIN SODIUM SALT
NIGERICIN SODIUM SALT structure
CAS No.
28380-24-7
Chemical Name:
NIGERICIN SODIUM SALT
Synonyms
x-464;Helix c;HELIXIN C;NIGERICIN;Aids003767;Aids-003767;AZALOMYCIN M;NIGERICIN NA;POLYETHERIN A;Antibiotic M 2
CBNumber:
CB4331016
Molecular Formula:
C40H68O11
Formula Weight:
724.96
MOL File:
28380-24-7.mol

NIGERICIN SODIUM SALT Properties

Melting point:
183.5-185°
alpha 
D24 +36.2° (c = 0.842 in CHCl3)
Boiling point:
779.9±60.0 °C(Predicted)
Density 
1.19±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
chloroform: 10 mg/mL, clear, colorless
pka
4.39±0.10(Predicted)
EWG's Food Scores
1
SAFETY
  • Risk and Safety Statements
Hazard Codes  T,Xi
Risk Statements  25-36/37/38
Safety Statements  26-36/37/39-45-36
RIDADR  UN 3462 6.1/PG 3
WGK Germany  3
RTECS  QT6840000
10
HazardClass  6.1(b)
PackingGroup  III
HS Code  29419090
Toxicity LD50 in mice (mg/kg): 10-15 i.p. (Shoji); also reported as 2.5 i.p. (Harned)

NIGERICIN SODIUM SALT Chemical Properties,Uses,Production

Uses

Nigericin is a polyether antibiotic produced by Streptomyces, notably S. hygroscopicus, isolated in the 1950s. Its complex structure was finally elucidated in 1968. Nigericin is an ionophore, possessing very high affinity for monovalent cations such as Na+ and K+. Nigericin disrupts membrane potential and Golgi apparatus in mitochondria. Although nigericin can be isolated as the free acid (under acidic conditions), like most ionophores it is extracted into organic solvents and is most conveniently isolated as a salt. In vitro, nigericin has broad biological activity against Gram positive bacteria, fungi, tumour cell lines and some viruses, including HIV. Nigericin is the most common member of the polyether class which are common false positives in in vitro screening bioassays using crude microbial extracts. They are thus important standards for dereplication.

Definition

ChEBI: A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.

NIGERICIN SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products


NIGERICIN SODIUM SALT Suppliers

Global( 94)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Excellent Biotech Co., Ltd.
13480692018
ramyan@ex-biotech.com;sale@ex-biotech.com CHINA 955 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29864 58
Fuxin Pharmaceutical
021-50872116
contact@fuxinpharm.com CHINA 9520 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
86-021-61999440
contact@trustwe.com CHINA 10005 58
SIMAGCHEM CORP
13806087780 +86 13806087780
shaobowang@simagchem.com CHINA 17384 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58
Zhejiang Huida Biotech Co., LTD
8615669048680 008613515763466
wendy@huidabiotech.com CHINA 87 58
ShenZhen Ipure Biology import and export company co.,ltd
18071025641 18071025641
eric@ipurechemical.com CHINA 11336 58
Baoji Guokang Healthchem co.,ltd
09178656283
cngksw@aliyun.com CHINA 9474 58

View Lastest Price from NIGERICIN SODIUM SALT manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-01-13 NIGERICIN SODIUM SALT
28380-24-7
US $1.00 / KG 1KG 98%-99.9% 200kg Career Henan Chemical Co

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