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Nitidine chloride

Nitidine chloride
Nitidine chloride structure
Chemical Name:
Nitidine chloride
NITIDINE;Angolinine;Nitidine chloride;NITIDINE CHLORIDE (RG);dimethoxy-12-methyl-,chloride;[1,3]Dioxolo[4,5]benzo[1,2-c]phenanthridinium, 2,3-;Nitidine chloride, 98%, from Zanthoxylum nitidum (Roxb.) DC.;2,3-Dimethoxy-12-methyl-(1,3)-benzodioxolo(5,6-c)phenanthridinium chloride;2,3-DiMethoxy-12-Methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-iuM chloride
Molecular Formula:
Formula Weight:
MOL File:

Nitidine chloride Properties

Melting point:
283-286 °C
storage temp. 
DMSO: soluble1mg/mL, clear (warmed)
white to beige
  • Risk and Safety Statements
Safety Statements  24/25
WGK Germany  3
RTECS  DF4935500
HS Code  29399990

Nitidine chloride price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0610 Nitidine chloride ≥97% (HPLC) 13063-04-2 5mg $103 2021-03-22 Buy
Sigma-Aldrich SML0610 Nitidine chloride ≥97% (HPLC) 13063-04-2 25mg $415 2021-03-22 Buy
Cayman Chemical 29223 Nitidine (chloride) 13063-04-2 100mg $765 2021-03-22 Buy
Cayman Chemical 29223 Nitidine (chloride) 13063-04-2 10mg $86 2021-03-22 Buy
Cayman Chemical 29223 Nitidine (chloride) 13063-04-2 5mg $45 2021-03-22 Buy

Nitidine chloride Chemical Properties,Uses,Production


This quaternary alkaloid occurs primarily in Zanthoxylum nitidum (Lam.) DC but has also been found in several species of Fagara. It is normally isolated as the chloride which forms bright yellow needles when recrystallized from EtOH-HCl. The crystals decompose on heating to 240°C yielding a product having m.p. 285-6°C. The iodide also forms yellow needles and undergoes a similar trans_x0002_formation at the same temperature to yield a product with the same melting point, possibly identical to that obtained from the chloride. The crystalline acetate, m.p. 255-260°C and the pseudocyanide, m.p. 215-6°C and decomposing completely at 234°C in vacuo have also been prepared. A periodide, which fonns chocolate-brown needles when crystallized from Me2CO, m.p. 300-1 °c (dec.) is useful for characterizing the base.


A solution of 1555 (0.102 g, 0.278 mmol) and triphosgene (0.179 g, 0.602 mmol) in acetonitrile (2.5 mL) was stirred at 60 C° (bath temperature) for 0.5 h. After the addition of ice/water, a yellow precipitate was collected by filtration and recrystallized from ethanol/diethyl ether to directly afford nitidine chloride (0.098 g, 91%); mp 285–292 C°.

An isocyano group can serve as both a protecting group for the amino function, and, due to its electronic effect, as an activating group as well. These two functionalities are employed in a synthetic route whereby an amino function has to be protected and a condensation reaction is performed at the a-carbon atom, for which activation is required.
3,4-Fused tryptophan analogues 1563 and 1564 contain a ring that bridges the a-carbon and the 4-position of the indole ring, thus limiting the conformational flexibility of the side chain. The synthesis proceeds from N-formylated 40-bromotryptophan 1558 via isocyanide 1559, 2-propenoate 1560, and Pd-catalyzed cyclization of the a-2-propenyl dl-tryptophan derivatives 1561 and 1562 to give both the seven- and eight-membered constrained ring analogues 1564 and 1563. Dehydration of the formamide 1558 with triphosgene affords the isocyanide 1559 in 75% (87%) yield.


Arthur, Hui, Ng., Chern. Ind., 1514 (1958)
Arthur, Hui, Ng.,J. Chern. Soc., 1840 (1959)
Kuck, Albonico, Deulofeu., Chern. Ind., 945 (1966)

Nitidine chloride Preparation Products And Raw materials

Raw materials

Preparation Products

Nitidine chloride Suppliers

Global( 163)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Chengdu GLP biotechnology Co Ltd
13350802083 028-87075086 CHINA 1824 58
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070 CHINA 3013 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3623 58
career henan chemical co
+86-371-86658258 CHINA 29961 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897 CHINA 2712 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768 CHINA 2972 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28229 58
Xi'an Kono chem co., Ltd.,
13289246953 029-86107037 CHINA 3000 58
Chongqing Chemdad Co., Ltd
+86-13650506873 CHINA 37282 58
Shanghai Standard Technology Co., Ltd.
+86-21-57127007-6606 CHINA 1923 58

View Lastest Price from Nitidine chloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-05-11 Nitidine Chloride
US $0.00 / mg 5mg ≥97%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
2019-07-06 Nitidine chloride
US $1.00 / kg 1g 99% 100KG career henan chemical co

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