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MONOCROTALINE

Description References
MONOCROTALINE
MONOCROTALINE structure
CAS No.
315-22-0
Chemical Name:
MONOCROTALINE
Synonyms
A 6080;CROTALIN;CROTALINE;NSC 28693;NCI-C56462;MONOCROTALIN;Bulbus Lilii;MONOCROTALINE;Monccrotalire;MONOCRATALINE
CBNumber:
CB4361934
Molecular Formula:
C16H23NO6
Formula Weight:
325.36
MOL File:
315-22-0.mol

MONOCROTALINE Properties

Melting point:
204 °C (dec.)(lit.)
alpha 
-54.8o (C=5 IN CHLOROFORM)
Boiling point:
463.55°C (rough estimate)
Density 
1.1512 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
2-8°C
form 
neat
Merck 
13,6274
BRN 
48732
InChIKey
QVCMHGGNRFRMAD-XFGHUUIASA-N
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H351
Precautionary statements  P281-P301+P310
Hazard Codes  T
Risk Statements  25-40-35
Safety Statements  36/37/39-45
RIDADR  UN 1544 6.1/PG 3
WGK Germany  3
RTECS  QB3140000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29399990
Toxicity LD50 orally in rats: 71 mg/kg (Newberne)

MONOCROTALINE price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C2401 Crotaline 315-22-0 1g $397 2018-11-13 Buy
Sigma-Aldrich 37024 Monocrotaline analytical standard 315-22-0 0.1mg $821 2018-11-20 Buy
Cayman Chemical 16666 Monocrotaline ≥98% 315-22-0 50mg $49 2018-11-13 Buy
Cayman Chemical 16666 Monocrotaline ≥98% 315-22-0 1g $343 2018-11-13 Buy
Sigma-Aldrich C2401 Crotaline 315-22-0 500mg $231 2018-11-13 Buy

MONOCROTALINE Chemical Properties,Uses,Production

Description

Monocrotaline (MCT) is a toxic 11-membered macrocyclic pyrrolizidine alkaloid (PA) derived from the seeds of the Crotalaria spectabilis plant. It poisons livestock and humans through the ingestion of contaminated grains and other foods. Pyrrolizidine alkaloid is activated by cytochrome P450 to the reactive pyrrole metabolite dehydromonocrotaline (MCTP) in the liver. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature.
Monocrotaline is produced for research use. It is used in rat model to investigate human pulmonary hypertension as it offers technical simplicity, reproducibility, and low cost compared with other models of pulmonary hypertension.

References

[1] Jose G. Gomez-Arroyo, Laszlo Farkas, Aysar A. Alhussaini, Daniela Farkas, Donatas Kraskauskas, Norbert F. Voelkel, Harm J. Bogaard (2012) The monocrotaline model of pulmonary hypertension in perspective, Am J Physio Lung Cell Mol Phyisol, 302, L363-L369
[2] https://pubchem.ncbi.nlm.nih.gov/compound/monocrotaline#section=Top

Chemical Properties

White to light tan powder

Uses

A toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats.

Uses

antineoplastic, insect sterilant

Safety Profile

Suspected carcinogen with experimental carcinogenic data. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Crotaline forms prisms from absolute EtOH and recrystallises also from CHCl3. UV in 96% EtOH has max 217nm (log  3.32). [Adams et al. J Am Chem Soc 74 5612 1952, Culvenor & Smith Aust J Chem 10 474 1957.] The hydrochloride has m 212-214o (from MeOH/Et2O) and [] D28 -38.4o (c 5, H2O) [Adams & Gianturco J Am Chem Soc 78 1922 1956]. The picrate has m 230-231.5o(dec) [Adams et al. J Am Chem Soc 74 5614 1952]. [Beilstein 27 III/IV 6660.]

MONOCROTALINE Preparation Products And Raw materials

Raw materials

Preparation Products


MONOCROTALINE Suppliers

Global( 137)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2258 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30003 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4001 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23049 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35440 58
Chengdu Must Bio-Technology Co., Ltd 86-028-85287229
86-028-87384368 Anniedai0203@gmail.com China 896 60
Beijing OKA biological technology co., LTD 010-62971590; 62971690; 13718666987
010-62971690 1534154405@qq.com China 9987 58

View Lastest Price from MONOCROTALINE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-10 MONOCROTALINE
315-22-0
US $1.00 / KG 1KG 98% 1kg,5kg,100kg career henan chemical co
2018-12-24 MONOCROTALINE
315-22-0
US $2.00 / kg 1kg 99% 100kg career henan chemical co

MONOCROTALINE Spectrum


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