β-Boswellic Acid
- CAS No.
- 631-69-6
- Chemical Name:
- β-Boswellic Acid
- Synonyms
- BRN0077366;Masticinic acid;B-BOSWELLIC ACID;Β-BOSWELLIC ACID;β-Boswellic Acid;BOSWELLIC ACID, B-;BETA-BOSWELLIC ACID;BOSWELLIC ACID, a-(P);β-Boswellic Acid USP/EP/BP;NBGQZFQREPIKMG-PONOSELZSA-N
- CBNumber:
- CB4427357
- Molecular Formula:
- C30H48O3
- Molecular Weight:
- 456.71
- MDL Number:
- MFCD04039448
- MOL File:
- 631-69-6.mol
- MSDS File:
- SDS
| Melting point | 130-135°C |
|---|---|
| alpha | D +107° (c = 0.75 in CHCl3) |
| Boiling point | 556.0±50.0 °C(Predicted) |
| Density | 1.09±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| pka | 4.50±0.70(Predicted) |
| color | Off-White |
| Water Solubility | practically insoluble in water |
| InChIKey | NBGQZFQREPIKMG-AKOQEMLPSA-N |
| LogP | 9.105 (est) |
| CAS DataBase Reference | 631-69-6 |
| FDA UNII | B252M1YO2V |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
β-Boswellic Acid price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 80342 | β-Boswellic acid analytical standard | 631-69-6 | 5mg | $561 | 2024-03-01 | Buy |
| Cayman Chemical | 11693 | β-Boswellic Acid ≥95% | 631-69-6 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 11693 | β-Boswellic Acid ≥95% | 631-69-6 | 5mg | $183 | 2024-03-01 | Buy |
| Cayman Chemical | 11693 | β-Boswellic Acid ≥95% | 631-69-6 | 10mg | $321 | 2024-03-01 | Buy |
| Usbiological | 361758 | Beta-Boswellic acid | 631-69-6 | 10mg | $632 | 2021-12-16 | Buy |
β-Boswellic Acid Chemical Properties,Uses,Production
Description
β-Boswellic acid is a pentacyclic triterpene originally isolated from Boswellia that has diverse bioactivities. It inhibits 5-lipoxygenase (5-LO) with an IC50 value of approximately 5 μM but is less potent than its derivative 3-acetyl-11-keto-β-boswellic acid . It inhibits cell proliferation in HL-60 cells with IC50 values of 3.7, 7.1, and 6.3 μM for DNA, RNA, and protein synthesis, respectively. In human umbilical vein endothelial cells (HUVECs) transiently deprived of oxygen and glucose, β-boswellic acid increases nitric oxide and increases phosphorylation of enzyme nitric oxide synthase (eNOS). It also increases calcium mobilization in platelets at concentrations ≥3 μM and induces platelet aggregation (EC50 = 8 μM).
Chemical Properties
BETA-BOSWELLIC ACID is Off-White Solid
Uses
The principal constitutents of frankincense (olibanum). A specific, nonredox inhibitor of 5-lipoxygenase used to treat inflammation.
Definition
ChEBI: Boswellic acid is a triterpenoid.
Anticancer Research
It is a natural pentacyclic triterpenediol and occurs in Boswellia serrata plants as anisomeric blend of 3α, 24-dihydroxyolean-12-ene and 3α, 24-dihydroxyurs-12-ene.It induces apoptosis in various cancer cells. The events involved in this process areexcessive reactive oxygen species (ROS), nitric oxide (NO) formation, DNA ladderformation, and increased sub-G0 phase in cell cycle. This ultimately results incleavage of Bcl-2 and translocation of Bax to mitochondria, which lead to the lossof mitochondrial potential and release of cyt-c and other factors into cytosol. All these events are linked with reduced expression of survivin and inhibitor of caspase-activatedDNases (ICAD) that leads to the activation of poly(ADP-ribose) polymerase(PARP). The triterpene upregulates the expression of cell death receptor-4(DR-4) and tumor necrosis factor receptor-1 (TNF-R1), where both lead to activationof caspase-8 (Huang et al. 2000; Desai et al. 2008; Lu et al. 2008).
β-Boswellic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
View Lastest Price from β-Boswellic Acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-23 | β-Boswellic Acid
631-69-6
|
US $0.00 / KG | 1KG | >99% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2023-10-10 | β-Boswellic Acid
631-69-6
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-09-06 | β-Boswellic Acid
631-69-6
|
US $30.00-10.00 / KG | 50KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. |
-
- β-Boswellic Acid
631-69-6
- US $0.00 / KG
- >99% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- β-Boswellic Acid
631-69-6
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- β-Boswellic Acid
631-69-6
- US $30.00-10.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
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