- β-Boswellic Acid
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- $0.00 / 1KG
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2025-11-13
- CAS:631-69-6
- Min. Order: 1KG
- Purity: >99% HPLC
- Supply Ability: 1000KG
- β-Boswellic acid
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- $59.00 / 1mg
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2025-11-10
- CAS:631-69-6
- Min. Order:
- Purity: 99.91%
- Supply Ability: 10g
- β-Boswellic Acid
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- $0.00 / 25KG
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2025-09-11
- CAS:631-69-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
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| | β-Boswellic Acid Basic information |
| Product Name: | β-Boswellic Acid | | Synonyms: | BETA-BOSWELLIC ACID;B-BOSWELLIC ACID;BOSWELLIC ACID, B-;Beta-BoswellicAcidforU.Lingner-HoffmannCHEMOSGmbHsales;(3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bR)-3-hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picene-4-carboxylic acid;BOSWELLIC ACID, a-(P);(3A,4B)-3-HYDROXYURS-12-EN-23-OIC ACID;(3a,4)-3-Hydroxyurs-12-en-23-oic Acid | | CAS: | 631-69-6 | | MF: | C30H48O3 | | MW: | 456.71 | | EINECS: | | | Product Categories: | Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Miscellaneous Natural Products | | Mol File: | 631-69-6.mol |  |
| | β-Boswellic Acid Chemical Properties |
| Melting point | 130-135°C | | alpha | D +107° (c = 0.75 in CHCl3) | | Boiling point | 556.0±50.0 °C(Predicted) | | density | 1.09±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | | pka | 4.50±0.70(Predicted) | | form | Solid | | color | Off-White | | Water Solubility | practically insoluble in water | | InChIKey | NBGQZFQREPIKMG-AKOQEMLPSA-N | | LogP | 9.105 (est) | | CAS DataBase Reference | 631-69-6 |
| | β-Boswellic Acid Usage And Synthesis |
| Description | β-Boswellic acid is a pentacyclic triterpene originally isolated from Boswellia that has diverse bioactivities. It inhibits 5-lipoxygenase (5-LO) with an IC50 value of approximately 5 μM but is less potent than its derivative 3-acetyl-11-keto-β-boswellic acid . It inhibits cell proliferation in HL-60 cells with IC50 values of 3.7, 7.1, and 6.3 μM for DNA, RNA, and protein synthesis, respectively. In human umbilical vein endothelial cells (HUVECs) transiently deprived of oxygen and glucose, β-boswellic acid increases nitric oxide and increases phosphorylation of enzyme nitric oxide synthase (eNOS). It also increases calcium mobilization in platelets at concentrations ≥3 μM and induces platelet aggregation (EC50 = 8 μM). | | Chemical Properties | BETA-BOSWELLIC ACID is Off-White Solid | | Uses | The principal constitutents of frankincense (olibanum). A specific, nonredox inhibitor of 5-lipoxygenase used to treat inflammation. | | Definition | ChEBI: Boswellic acid is a triterpenoid. | | Anticancer Research | It is a natural pentacyclic triterpenediol and occurs in Boswellia serrata plants as anisomeric blend of 3α, 24-dihydroxyolean-12-ene and 3α, 24-dihydroxyurs-12-ene.It induces apoptosis in various cancer cells. The events involved in this process areexcessive reactive oxygen species (ROS), nitric oxide (NO) formation, DNA ladderformation, and increased sub-G0 phase in cell cycle. This ultimately results incleavage of Bcl-2 and translocation of Bax to mitochondria, which lead to the lossof mitochondrial potential and release of cyt-c and other factors into cytosol. All these events are linked with reduced expression of survivin and inhibitor of caspase-activatedDNases (ICAD) that leads to the activation of poly(ADP-ribose) polymerase(PARP). The triterpene upregulates the expression of cell death receptor-4(DR-4) and tumor necrosis factor receptor-1 (TNF-R1), where both lead to activationof caspase-8 (Huang et al. 2000; Desai et al. 2008; Lu et al. 2008). | | References | [1] H.P.T. AMMON. Mechanism of antiinflammatory actions of curcumine and boswellic acids[J]. Journal of ethnopharmacology, 1993, 38 2: Pages 105-112. DOI: 10.1016/0378-8741(93)90005-p
[2] H SAFAYHI. Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase.[J]. Journal of Pharmacology and Experimental Therapeutics, 1992, 261 3: 1143-1146.
[3] Y SHAO. Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture.[J]. Planta medica, 1998, 64 4: 328-331. DOI: 10.1055/s-2006-957444
[4] MINGMING WANG. Pretreatment with β-Boswellic Acid Improves Blood Stasis Induced Endothelial Dysfunction: Role of eNOS Activation.[J]. Scientific Reports, 2015: 15357. DOI: 10.1038/srep15357
[5] ULF SIEMONEIT. Defined Structure-Activity Relationships of Boswellic Acids Determine Modulation of Ca2+ Mobilization and Aggregation of Human Platelets by Boswellia serrata Extracts.[J]. Planta medica, 2017, 83 12-13: 1020-1027. DOI: 10.1055/s-0043-107884 |
| | β-Boswellic Acid Preparation Products And Raw materials |
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