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Dihydrofolic acid

Dihydrofolic acid Structure
Dihydrofolic acid structure
CAS No.
4033-27-6
Chemical Name:
Dihydrofolic acid
Synonyms
dihydrofolate;FAH2;Dihydrofolic acid;FolinicAcidEPImpurityGHCl;Levofolinate EP Impurity G;Folinic Acid EP Impurity G;Impurity G (hydrochloride);7,8-Dihydrofolic acid (DHF);Dihydrofolic acid (Standard);DIHYDROPTEROYL-L-GLUTAMIC ACID
CBNumber:
CB4432012
Molecular Formula:
C19H21N7O6
Molecular Weight:
443.41
MDL Number:
MFCD00083619
MOL File:
4033-27-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:52:49
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Dihydrofolic acid Properties

Melting point >160°C (dec.)
Density 1.69±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility 0.1 M NaOH: 10 mg/mL, slightly hazy, orange
pka pKa 1.38(H2O t=25 I=0.10) (Occasionally);3.84(H2O t=25 I=0.10) (Occasionally)
form Solid
color Light Beige to Beige
biological source synthetic (organic)
BRN 69017
Stability Air Sensitive, Hygroscopic, Temperature Sensitive
InChIKey OZRNSSUDZOLUSN-LBPRGKRZSA-N
SMILES NC1=NC(=O)C2=C(NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=N2)N1
FDA UNII KXP0KNM559
UNSPSC Code 12352106
NACRES NA.79

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 0

Dihydrofolic acid price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D7006 Dihydrofolic acid ≥90% 4033-27-6 10mg $140 2026-04-30 Buy
Sigma-Aldrich D7006 Dihydrofolic acid ≥90% 4033-27-6 25mg $314 2026-04-30 Buy
Cayman Chemical 32750 Dihydrofolic Acid ≥90% 4033-27-6 5mg $63 2026-04-30 Buy
Cayman Chemical 32750 Dihydrofolic Acid ≥90% 4033-27-6 10mg $105 2026-04-30 Buy
Cayman Chemical 32750 Dihydrofolic Acid ≥90% 4033-27-6 25mg $229 2026-04-30 Buy
Product number Packaging Price Buy
D7006 10mg $140 Buy
D7006 25mg $314 Buy
32750 5mg $63 Buy
32750 10mg $105 Buy
32750 25mg $229 Buy

Dihydrofolic acid Chemical Properties, Uses, Production

Uses

antidote to methotrexate toxicity

Uses

Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF).

Definition

ChEBI: Dihydrofolic acid is a folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. It interacts with bacteria during cell division and is targeted by various drugs to prevent nucleic acid synthesis. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a dihydrofolate(2-).

General Description

Intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). In bacteria, dihydrofolic acid is generated from 7,8-dihydropteroate by dihydrofolate synthetase.

Biochem/physiol Actions

Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).

Purification Methods

DHFA is best purified by suspending (1g mostly dissolved)) in ice-cold sodium ascorbate (300mL of 10% at pH 6.0, prepared by adjusting the pH of 30g of sodium ascorbate in 150mL of H2O by adding 1N NaOH dropwise using a gla

Dihydrofolic acid Preparation Products And Raw materials

Raw materials

Preparation Products

5,10-DiforMyl-5,6,7,8-tetrahydro Folic Acid L-Tetrahydrofolic Acid

Dihydrofolic acid Suppliers

Global Suppliers ( 122)
Supplier Tel Email Country ProdList Advantage
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5984 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865 han_yajun@dctc.daicel.com China 7916 65
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123 sj_scrc@sinopharm.com China 9791 79
S.Z. PhyStandard Bio-Tech. Co., Ltd. 0755-4000505016 13380397412 3001272453@qq.com China 4999 50
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29977 65
Shanghai TaoSu Biochemical Technology Co., Ltd. 021-33632979 info@tsbiochem.com China 8039 58
TianJin Alta Scientific Co., Ltd. 022-65378550-8551 contact@altascientific.com China 2772 58
Supplier Advantage
Nantong QuanYi Biotechnology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Chemsky（shanghai）International Co.,Ltd. 50
Daicel Chiral Technologies (China)CO.,LTD 65
Syntechem Co.,Ltd 57
Sinopharm Chemical Reagent Co,Ltd. 79
S.Z. PhyStandard Bio-Tech. Co., Ltd. 50
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Shanghai TaoSu Biochemical Technology Co., Ltd. 58
TianJin Alta Scientific Co., Ltd. 58

View Latest Price from Dihydrofolic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DIHYDROFOLIC ACID pictures 2026-08-07 DIHYDROFOLIC ACID
4033-27-6
 $1.00-2.00 1KG 99% 10000KG Shaanxi Dideu Medichem Co. Ltd
DIHYDROFOLIC ACID pictures 2026-08-07 DIHYDROFOLIC ACID
4033-27-6
 10KG 99%+ 10000KG Shaanxi Dideu Medichem Co. Ltd
Dihydrofolic acid pictures 2026-07-15 Dihydrofolic acid
4033-27-6
 $1520.00-1980.00 10g TargetMol Chemicals Inc.

4033-27-6 (Dihydrofolic acid) Related Search:

Vitamin B12 Glycine Folic Acid Impurity C 6-hydroxymethylpterin (S)-N-[4-[[(2-AMino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)Methyl]aMino]benzoyl]-L-glutaMic Acid
2,4,5-Triamino-6-hydroxypyrimidine sulfate 2-Amino-7-(chloromethyl)pteridin-4(1H)-one Folinic Acid IMpurity E 10-Formylfolic Acid 5,10-DiforMyl-5,6,7,8-tetrahydro Folic Acid
Calcium N5-methyltetrahydrofolate Folic acid 2-[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)methyl-formyl-amino]benzoyl]aminopentanedioic acid Calcium levofolinate 5-Methyl Tetrahedropteroic Acid (Mixture of DiastereoMers)
folcysteine (2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6- yl]methylamino]benzoyl]amino]pentanedioic acid 6-Hydroxy-2,4,5-triaminopyrimidine

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FAH2 DIHYDROPTEROYL-L-GLUTAMIC ACID 2-[4-[(2-amino-4-oxo-7,8-dihydro-1H-pteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid 7,8-Dihydropteroyl-L-glutamic acid, Dihydropteroyl-L-glutamic acid, FAH2 N-[4-[[[(2-Amino-1,4,5,6-tetrahydro-4-oxopteridin)-6-yl]methyl]amino]benzoyl]-L-glutamic acid (S)-2-(4-(((2-aMino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid 7,8-Dihydrofolic acid (DHF) Dihydrofolic acid 7,8-Dihydropteroyl-L-glutaMic acid N-[4-[[(2-aMino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)Methyl]aMino]benzoyl]-L-GlutaMic acid Folinic Acid Impurity G (7,8-Dihydrofolic Acid) 7,8-DIHYDROPTEROYL-L-GLUTAMIC ACID 2-(4-(((2-Amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid Folic Acid 7,8-Dihydro Impurity Levofolinate EP Impurity G L-Glutamic acid, N-[4-[[(2-amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]- Impurity G of Calcium Levofolinate Folic acid impurity 2/Folinic Acid EP Impurity G/Dihydrofolic acid/7,8-Dihydrofolic Acid Folinic Acid EP Impurity G Folinic Acid EP Impurity G (7,8-Dihydrofolic Acid) dihydrofolate (4-(((2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid Calcium levoflonate EP impurity G FolinicAcidEPImpurityGHCl (S)-2-(4-(((2-Amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid (4-(((2-Imino-4-Oxo-1,2,3,4,7,8-Hexahydropteridin-6-Yl)Methyl)Amino)Benzoyl)-L-Glutamicacid Impurity G (hydrochloride) Folinic Acid EP Impurity G Sulfate Dihydrofolic acid (Standard) Dihydrofolic acid 4033-27-6 40033-27-6 C19H21N7O6 Cell Signaling Enzymes Application Index Biochemicals and Reagents BioChemical Cofactors Dihydrofolate reductase Enzymes, Inhibitors, and Substrates Oxidation-Reduction Substrate/Cofactor