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L-Tetrahydrofolic Acid

L-Tetrahydrofolic Acid
L-Tetrahydrofolic Acid structure
Chemical Name:
L-Tetrahydrofolic Acid
C00101;(6S)-Thfa;l-amino)benzoyl);Tetrahydofolic acid;TETRAHYDROFOLIC ACID;Tetrahydrofolic acide;L-Tetrahydrofolic Acid;Folic Acid Impurity 11;(6S)-Tetrahydrofolic acid;THFA Tetrahydrofolic acid
Molecular Formula:
Formula Weight:
MOL File:

L-Tetrahydrofolic Acid Properties

Boiling point:
555.12°C (rough estimate)
1.4216 (rough estimate)
refractive index 
1.6800 (estimate)
storage temp. 
off-white to tan
We have observed that this material decomposes steadily over time. Use immediately upon receipt.
  • Risk and Safety Statements
WGK Germany  3
RTECS  MA0600800

L-Tetrahydrofolic Acid price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T3125 Tetrahydrofolic acid ≥65% (when packaged), powder 135-16-0 25mg $49.4 2018-11-13 Buy
Sigma-Aldrich T3125 Tetrahydrofolic acid ≥65% (when packaged), powder 135-16-0 1g $698 2018-11-13 Buy
Sigma-Aldrich T3125 Tetrahydrofolic acid ≥65% (when packaged), powder 135-16-0 100mg $136 2018-11-13 Buy

L-Tetrahydrofolic Acid Chemical Properties,Uses,Production

Chemical Properties

Light Tan Solid


Asa folic acid derivative and coenzyme, L-Tetrahydrofolic Acid can be involved in the metabolism of amino and nucleic acids.


ChEBI: A derivative of folic acid in which the pteridine ring is fully reduced; it is the parent compound of a variety of coenzymes that serve as carriers of one-carbon groups in metabolic reactions.

Purification Methods

Very high quality material is now available commercially, and it should be a white powder. It can be dried over P2O5 in a vacuum desiccator and stored in weighed aliquots in sealed ampoules. It is stable at room temperature in sealed ampoules for many months and for much more extended periods at -10o. When moist, it is extremely sensitive to air whereby it oxidises to the yellow 7,8-dihydro derivative. In solution it turns yellow in colour as it oxidises, and then particularly in the presence of acids it turns dark reddish brown in colour. Hence aqueous solutions should be frozen immediately when not in use. It is always advisable to add 2-mercaptoethanol (if it does not interfere with the procedure for which it is used) which stabilises it by depleting the solution of O2. The sulfate salt is more stable but is much less soluble. The best way to prepare standard solutions of this acid is to dissolve it in the desired buffer and estimate the concentration by UV absorption in pH 7 buffer at 297nm ( 22,000 M-1cm-1). If a sample is suspect, it is not advisable to purify it because it is likely to deteriorate further as “dry box” conditions are necessary. Either a new sample is purchased or one is freshly prepared from folic acid. It has the above pKa values. [Hafeti et al. Biochemical Preparations 7 89 1960, UV: Mathews & Huennekens J Biol Chem 235 3304 1960, Osborn & Huennekens J Biol Chem 233 969 1958, O'Dell et al. J Am Chem Soc 69 250 1947, Blakley Biochem J 6 5 331 1957, Asahi Yakugaku Zasshi (J Pharm Soc Jpn) 79 1548 1959, Beilstein 26 III/IV 3879.]

L-Tetrahydrofolic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

L-Tetrahydrofolic Acid Suppliers

Global( 49)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Zhejiang ZETian Fine Chemicals Co. LTD
+86-18957127338 CHINA 2224 58
(323) 306-3136
(626) 453-0409 United States 8407 58
Standardpharm Co. Ltd.
0714-3992388 CHINA 13064 58
BOC Sciences
1-631-614-7828 United States 20115 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933; China 96815 76
BePharm Ltd 4001-647-117; 021-61629020
021-61629029 China 24689 61
Chemsky(shanghai)International Co.,Ltd. 021-50135380 China 32362 50
Syntechem Co.,Ltd Please Email
E-Mail Inquiry China 13010 57
Spectrum Chemical Manufacturing Corp. 021-67601398,18616765336,QQ:3003443155
021-57711696 China 9689 60
Chengdu NoVi Biotechnology Co., Ltd. 028-81458053;13551243286;QQ:987166710
028-81458053 China 226 55

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