LIQUIRITIGENIN
- CAS No.
- 578-86-9
- Chemical Name:
- LIQUIRITIGENIN
- Synonyms
- liquirtigenin;(2S)-Liquiritigenin;Aids095895;Aids-095895;LIQUIRITIGENIN;S-liquiritigenin;LIQUIRITIGENIN(P);Glycyrrhizin R-19;(-)-Liquiritigenin;Liquiritigenin HPLC
- CBNumber:
- CB4434177
- Molecular Formula:
- C15H12O4
- Molecular Weight:
- 256.25
- MDL Number:
- MFCD00287289
- MOL File:
- 578-86-9.mol
Melting point | 206-208°C |
---|---|
Boiling point | 529.5±50.0 °C(Predicted) |
Density | 1.386±0.06 g/cm3(Predicted) |
Flash point | 207℃ |
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | DMSO : 125 mg/mL (487.80 mM; Need ultrasonic) |
form | powder |
pka | 7.71±0.40(Predicted) |
color | White |
BRN | 359378 |
InChIKey | FURUXTVZLHCCNA-AWEZNQCLSA-N |
FDA UNII | T194LKP9W6 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
WGK Germany | 3 |
HS Code | 29329990 |
LIQUIRITIGENIN price More Price(37)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 78825 | Liquiritigenin ≥97.0% (HPLC) | 578-86-9 | 10mg | $281 | 2024-03-01 | Buy |
Sigma-Aldrich | 78825 | Liquiritigenin ≥97.0% (HPLC) | 578-86-9 | 50mg | $745 | 2024-03-01 | Buy |
Usbiological | 255689 | Liquiritigenin | 578-86-9 | 10mg | $489 | 2021-12-16 | Buy |
Usbiological | 300573 | Liquiritigenin | 578-86-9 | 20mg | $390 | 2021-12-16 | Buy |
TRC | L468820 | Liquiritigenin | 578-86-9 | 5mg | $165 | 2021-12-16 | Buy |
LIQUIRITIGENIN Chemical Properties,Uses,Production
Description
Liquiritigenin is an active estrogenic component in extracts of Glycyrrhizae radix. Glycyrrhizae radix (G. radix, licorice, liquorice) is frequently used for life-enhancing properties, for the treatment of injury or swelling, for detoxification in traditional Oriental medicine, as well as a food supplement in many of the countries in the world. Liquiritigenin is a selective estrogen receptor-β (ERβ) agonist. Liquiritigenin activates multiple ER regulatory elements and native target genes with ERβ but not ERα. The ERβ-selectivity of liquiritigenin is due to the selective recruitment of the coactivator steroid receptor coactivator-2 to target genes.
As the targeting ERβ is associated with anti-inflammatory effects, liquiritigenin exerts anti-inflammatory effects. Liquiritigenin is also reported to antihyperlipidemic, antiallergic and antihepatocellular carcinoma effects.
References
[1] J. E. Mersereau, N. Levy, R. E. Staub, S. Baggett, T. Zogric, S. Chow, W. A. Ricke, M. Tagliaferri, I. Cohen, L. F. Bjeldanes (2008) Liquiritigenin is a plant-derived highly selective estrogen receptor β agonist, Molecular and Cellular Endocrinology, 283, 49-57
[2] Di Wang, Jiahui Lu, Yan Liu, Qingfan Meng, Jing Xie, Zhenzuo Wang,Lesheng Teng (2014) Liquiritigenin Induces Tumor Cell Death through Mitogen-Activated Protein Kinase- (MPAKs-) Mediated Pathway in Hepatocellular Carcinoma Cells, BioMed Research International, 2014, Article ID 965316
Uses
Liquiritigenin has been used:
- to study its inhibitory effect on tumor metastasis in the treatment of colorectal cancer
- as a reference standard for ultra-performance liquid chromatography (UPLC) of Chaihu-Shugan-San (CSS) extract
- as a potential antiviral drug against hepatitis C virus (HCV) infection
Definition
ChEBI: A dihydroxyflavanone compound having the two hydroxy substituents at the 4'- and 7-positions. Isolated from the root of Glycyrrhizae uralensis, it is a selective agonist for oestrogen receptor beta.
General Description
Liquiritigenin is a flavonoid and an estrogenic compound found in licorice (Glycyrrhizae radix) root extract and several other plants.
Biochem/physiol Actions
Liquiritigenin displays anti-diabetic and choleretic properties. It exerts anti-inflammatory activity on Raw246.7 cells by inhibiting nuclear factor kappa light chain enhancer of activated B cells (NF-κB)-dependent-induction of inducible NOS (iNOS). Liquiritigenin inhibits liver fibrogenesis by blocking Hippo/Yes-associated protein (YAP) and transforming growth factor-β1 (TGF-β1)/small mothers against decapentaplegic (Smad) components. It is a selective estrogen receptor β agonist cells. Liquiritigenin induces apoptosis in SMM-721 cells by disruption of the mitochondrial membrane potential and increased production of reactive oxygen species.
Purification Methods
It crystallises from aqueous 50% EtOH. [Beilstein 18 III/IV 1780, 18/4 V 82.]
LIQUIRITIGENIN Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12446 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5892 | 58 |
Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-17333973358 | sales06@hbduling.cn | China | 8054 | 58 |
Chongqing Zhihe Biopharmaceutical Co., Ltd. | +8618580541567 | sales@zhswyy.com | China | 303 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21666 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9308 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
View Lastest Price from LIQUIRITIGENIN manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-25 | Liquiritigenin Glycyrrhiza extract
578-86-9
|
US $0.00 / KG | 1KG | 1%-98% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. | ||
2024-09-23 | Liquiritigenin
578-86-9
|
US $10.00 / kg | 1kg | 98% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD | ||
2024-09-19 | LIQUIRITIGENIN
578-86-9
|
US $0.00-0.00 / kg | 0.10000000149011612kg | 20%-98%HPLC | 20tons | Chongqing Zhihe Biopharmaceutical Co., Ltd. |
- Liquiritigenin Glycyrrhiza extract
578-86-9
- US $0.00 / KG
- 1%-98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
- Liquiritigenin
578-86-9
- US $10.00 / kg
- 98%
- Hebei Chuanghai Biotechnology Co,.LTD
- LIQUIRITIGENIN
578-86-9
- US $0.00-0.00 / kg
- 20%-98%HPLC
- Chongqing Zhihe Biopharmaceutical Co., Ltd.