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Novobiocin

Novobiocin
Novobiocin structure
CAS No.
303-81-1
Chemical Name:
Novobiocin
Synonyms
pa93;novo-r;U 6391;C05080;albamix;inamycin;cathocin;robiocina;NOVOBIOCIN;cathomycin
CBNumber:
CB4500553
Molecular Formula:
C31H36N2O11
Formula Weight:
612.62
MOL File:
303-81-1.mol

Novobiocin Properties

Melting point:
170-172 °C
alpha 
D24 -63.0° (c = 1 in ethanol)
Boiling point:
657.29°C (rough estimate)
Density 
1.3448
refractive index 
1.5800 (estimate)
pka
pKa1 4.3; pKa2 9.1(at 25℃)
FDA 21 CFR
556.460; 558.415; 558.4
NCI Dictionary of Cancer Terms
novobiocin
FDA UNII
17EC19951N
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H317
Precautionary statements  P280-P301+P312+P330
WGK Germany  3
HS Code  2941906000

Novobiocin price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1475008 Novobiocin 303-81-1 200mg $350 2021-12-16 Buy
Usbiological N5376-61 Novobiocin 303-81-1 5mg $362 2021-12-16 Buy
TRC N825320 Novobiocin 303-81-1 500mg $805 2021-12-16 Buy
TRC N825320 Novobiocin 303-81-1 25mg $90 2021-12-16 Buy
TRC N825320 Novobiocin 303-81-1 100mg $180 2021-12-16 Buy

Novobiocin Chemical Properties,Uses,Production

Chemical Properties

A light-yellow to white antibiotic produced by Streptomyces niveus. Available as calcium and sodium salts.

Originator

Albamycin,Upjohn,US,1956

Uses

Novobiocin is an aminocoumarin antibiotic isolated from a number of species of Streptomyces. Novobiocin exhibits broad spectrum Gram positive activity and was used clinically. Novobiocin is a potent inhibitor of bacterial DNA gyrase and a competitive inhibitor of the ATPase reaction catalysed by GyrB.

Uses

Novobiocin is an aminocoumarin antibiotic used in the treatment of Staphylococcus epidermis.

Definition

ChEBI: A coumarin-derived antibiotic obtained from Streptomyces niveus.

Manufacturing Process

The preparation of novobiocin by fermentation is described in US Patent 3,049,534 as follows: A medium containing 2% soybean meal, 1% dextrose, 0.25% sodium chloride and 0.75% distiller's solubles was made up in tap water. About 25 ml of the prepared medium was placed in a 75 ml vial and sterilized by heating at 120°C for 20 minutes. The sterilized medium was then inoculated with a vegetative culture of Streptomyces spheroides MA-319 (NRRL 2449), and the vial loosely stoppered with cotton. The vial was then placed on a shaking machine with an amplitude of 1? inches at 28°C for 6 days. At the end of this fermentation time, the fermented broth was assayed using the cylinder-plate method with Bacillus megatherium ATCC 9885 as the assay organism and found to have an activity of 600 units/ml or 30 mcg/ml of novobiocin. The production of larger quantities of novobiocin by submerged fermentation in suitable tanks is also described in US Patent 3,049,534.
The preparation of novobiocin by a synthetic route is described in US Patent 2,966,484, as well as in US Patent 2,925,411.

brand name

Albamycin.

Therapeutic Function

Antibiotic

World Health Organization (WHO)

Novobiocin, an antibiotic with a narrow spectrum of activity, was introduced in 1956. Its use was subsequently associated with serious adverse effects including blood dyscrasias. In view of its toxicity there are no current valid indications for its use. Although preparations containing novobiocin may remain available in some countries it has largely lapsed into disuse.

Hazard

May have damaging side effects.

Veterinary Drugs and Treatments

Novobiocin is approved as a single agent and in combination with penicillin G for use in dry dairy cattle as a mastitis tube. Novobiocin is available in combination with tetracycline and prednisolone for oral use in dogs.

Novobiocin Preparation Products And Raw materials

Raw materials

Preparation Products


Novobiocin Suppliers

Global( 70)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
career henan chemical co
15093356674 0371-55982848
0086-371-86658258 factory@coreychem.com CHINA 29864 58
Shaanxi Dideu Medichem Co. Ltd
15336106720
029-88380327 1017@dideu.com CHINA 3979 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671
0551-65418697 sales@tnjchem.com CHINA 37441 58
Guangzhou Sunton Biotechnology Co., Ltd.
18501706408 18575736215
18575736215 sunton01@sunton88.com CHINA 1355 58
Shaanxi Dideu Medichem Co. Ltd
18192503167 +86-29-89586680
+86-29-88380327 1005@dideu.com CHINA 9938 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 30014 58
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
86-21-63290778 86-21-63218885 sj_scrc@sinopharm.com China 9844 79
Hangzhou Yuhao Chemical Technology Co., Ltd 0571-82693216
+86-571-82880190 info@yuhaochemical.com China 9405 52
BOC Sciences 16314854226
info@bocsci.com United States 21113 65

View Lastest Price from Novobiocin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-19 Novobiocin powder
303-81-1
US $48.00-40.00 / KG 1KG 99% 200tons Guangzhou Sunton Biotechnology Co., Ltd.
2021-06-25 Novobiocin USP/EP/BP
303-81-1
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
2020-05-10 novobiocin
303-81-1
US $1.00 / KG 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd

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