ChemicalBook >> CAS DataBase List >>1,1,1,2,3,3,3-Heptafluoropropane


Chemical Name:
hfc-227ea;R227ea;R227;HFC-227;HEPTAFLUOROPROPANE;FM-200;Apaflurane;2-hydroheptafluoropropane;Propane, 1,1,1,2,3,3,3-heptafluoro-;R 227ea
Molecular Formula:
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Last updated:2023-05-25 18:01:10

1,1,1,2,3,3,3-Heptafluoropropane Properties

Melting point -126.8°C
Boiling point -16.4°C
Density 1,409 g/cm3
refractive index 1.2747 (estimate)
solubility Soluble 1 in 1725 parts of water at 20°C.
Stability Stable. Incompatible with strong oxidizing agents, alkali metals
LogP 1.610 (est)
CAS DataBase Reference 431-89-0(CAS DataBase Reference)
EWG's Food Scores 1
NIST Chemistry Reference 1,1,1,2,3,3,3-Heptafluoropropane(431-89-0)
EPA Substance Registry System HFC-227ea (431-89-0)


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
Signal word  Warning
Hazard statements  H280-H315-H319-H335
Precautionary statements  P260-P271-P280
Hazard Codes  Xi
Safety Statements  23-38
RIDADR  3296
Hazard Note  Irritant
HazardClass  2.2
HS Code  2903460010
Toxicity mouse,LC,inhalation,> 7200gm/m3/4H (7200000mg/m3),BEHAVIORAL: MUSCLE WEAKNESSBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)LUNGS, THORAX, OR RESPIRATION: DYSPNEA,Toksikologicheskii Vestnik. Vol. (3), Pg. 37, 1996.
NFPA 704
1 1

1,1,1,2,3,3,3-Heptafluoropropane Chemical Properties,Uses,Production

Chemical Properties

Heptafluoropropane is a liquefied gas and exists as a liquid at room temperature when contained under its own vapor pressure, or as a gas when exposed to room temperature and atmospheric pressure. The liquid is practically odorless and colorless. The gas in high concentration has a faint etherlike odor. Heptafluoropropane is noncorrosive, nonirritating, and nonflammable.


HFC 227ea is being developed as a CFC replacement in refrigerants, high temperature heat pumps, air-conditioning systems; as a fire suppressant; and for pharmaceutical aerosols and metered-dose inhalers.

Flammability and Explosibility

Non flammable

Pharmaceutical Applications

Heptafluoropropane is classified as a hydrofluorocarbon (HFC) aerosol propellant since the molecule consists only of carbon, fluorine, and hydrogen atoms. It does not contain any chlorine and consequently does not affect the ozone layer, nor does it have an effect upon global warming. It is therefore considered as an alternative propellant to CFCs for metered-dose inhalers (MDIs). While some of its physical and chemical properties are known, little has been published in regard to its use as a replacement for CFCs in MDIs.
The vapor pressure of heptafluoropropane is somewhat lower than that of tetrafluoroethane and dichlorodifluoromethane but considerably higher than the vapor pressure used to formulate most MDIs.
When heptafluoropropane is used for pharmaceutical aerosols and MDIs, the pharmaceutical grade must be specified. Industrial grades may not be suitable due to their impurity profile. Similarly to tetrafluoroethane, heptafluoropropane is not a good solvent for medicinal agents or for the commonly used surfactants and dispersing agents used in the formulation of MDIs.
There are several MDIs formulated with this propellant worldwide that contain a steroid as the active ingredient.


Heptafluoropropane is used as a fire extinguisher and is applicable as a non-CFC propellant in various metered-dose inhalers. Heptafluoropropane is regarded as nontoxic and nonirritating when used as directed. No acute or chronic hazard is present when it is used normally. Inhaling high concentrations of heptafluoropropane vapors can be harmful and is similar to inhaling vapors of other propellants. Deliberate inhalation of vapors of heptafluoropropane can be dangerous and may cause death. The same labeling required of CFC aerosols would be required for those containing heptafluoropropane as a propellant (except for the EPA requirement).


Heptafluoropropane is a nonreactive and stable material. The liquefied gas is stable when used as a propellant and should be stored in a metal cylinder in a cool, dry place.

2H-perfluoropropane 2-hydroperfluoropropane apaflurane(INN) Heptafluorpropan khladon227 propane,1,1,1,2,3,3,3-heptafluoro propane,1,1,1,2,3,3,3-heptafluoro- propane,1,1,1,2,3,3,3heptafluoro- R 227ea HYDROFLUOROCARBON 227ea 1,1,1,2,3,3,3-HEPTAFLUOROPROPANE 2H-HEPTAFLUOROPROPANE 1,1,1,2,3,3,3-heptafluoro-propan 2H-HEPTAFLUOROPROPANE 98% 2H-Heptafluoropropane97% 1,1,1,2,3,3,3-Heptafluorpropan 2H-HEPTAFLUOROPROPANE: 99.5% FIRE RETARDANT HFC-227 2H-Heptafluoropropane (FC-227ea) 97% Freons R227 1,1,1,2,3,3,3-Heptafluoropropane (FC 227ea) 1,1,1,2,3,3,3-Heptafluoropropane ISO 9001:2015 REACH Of seven fluorin propane TIANFU-CHEM 1,1,1,2,3,3,3-Heptafluoropropane HFC-227ea/FM200 2-hydroheptafluoropropane Apaflurane Propane, 1,1,1,2,3,3,3-heptafluoro- R227 R227ea HEPTAFLUOROPROPANE hfc-227ea HFC-227 FM-200 Famitinib Impurity 10 431-89-0 C3HF7 Refrigerant refrigerants