1,1,1,2,3,3,3-Heptafluoropropane
- CAS No.
- 431-89-0
- Chemical Name:
- 1,1,1,2,3,3,3-Heptafluoropropane
- Synonyms
- hfc-227ea;R227ea;R227;HFC-227;HEPTAFLUOROPROPANE;FM-200;Apaflurane;2-hydroheptafluoropropane;Propane, 1,1,1,2,3,3,3-heptafluoro-;R 227ea
- CBNumber:
- CB4692270
- Molecular Formula:
- C3HF7
- Molecular Weight:
- 170.03
- MDL Number:
- MFCD00043834
- MOL File:
- 431-89-0.mol
- MSDS File:
- SDS
| Melting point | -126.8°C |
|---|---|
| Boiling point | -16.4°C |
| Density | 1,409 g/cm3 |
| refractive index | 1.2747 (estimate) |
| solubility | Soluble 1 in 1725 parts of water at 20°C. |
| Stability | Stable. Incompatible with strong oxidizing agents, alkali metals |
| LogP | 1.610 (est) |
| CAS DataBase Reference | 431-89-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | R40P36GDK6 |
| NIST Chemistry Reference | 1,1,1,2,3,3,3-Heptafluoropropane(431-89-0) |
| EPA Substance Registry System | HFC-227ea (431-89-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS04,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H280-H315-H319-H335 | |||||||||
| Precautionary statements | P260-P271-P280 | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 23-38 | |||||||||
| RIDADR | 3296 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 2.2 | |||||||||
| HS Code | 2903460010 | |||||||||
| Toxicity | mouse,LC,inhalation,> 7200gm/m3/4H (7200000mg/m3),BEHAVIORAL: MUSCLE WEAKNESSBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)LUNGS, THORAX, OR RESPIRATION: DYSPNEA,Toksikologicheskii Vestnik. Vol. (3), Pg. 37, 1996. | |||||||||
| NFPA 704 |
|
1,1,1,2,3,3,3-Heptafluoropropane Chemical Properties,Uses,Production
Chemical Properties
Heptafluoropropane is a liquefied gas and exists as a liquid at room temperature when contained under its own vapor pressure, or as a gas when exposed to room temperature and atmospheric pressure. The liquid is practically odorless and colorless. The gas in high concentration has a faint etherlike odor. Heptafluoropropane is noncorrosive, nonirritating, and nonflammable.
Uses
HFC 227ea is being developed as a CFC replacement in refrigerants, high temperature heat pumps, air-conditioning systems; as a fire suppressant; and for pharmaceutical aerosols and metered-dose inhalers.
Flammability and Explosibility
Non flammable
Pharmaceutical Applications
Heptafluoropropane is classified as a hydrofluorocarbon
(HFC) aerosol propellant since the molecule consists only of carbon,
fluorine, and hydrogen atoms. It does not contain any chlorine and
consequently does not affect the ozone layer, nor does it have an
effect upon global warming. It is therefore considered as an
alternative propellant to CFCs for metered-dose inhalers (MDIs).
While some of its physical and chemical properties are known, little
has been published in regard to its use as a replacement for CFCs in
MDIs.
The vapor pressure of heptafluoropropane is somewhat
lower than that of tetrafluoroethane and dichlorodifluoromethane
but considerably higher than the vapor pressure used to formulate
most MDIs.
When heptafluoropropane is used for pharmaceutical
aerosols and MDIs, the pharmaceutical grade must be specified.
Industrial grades may not be suitable due to their impurity profile.
Similarly to tetrafluoroethane, heptafluoropropane is not a good
solvent for medicinal agents or for the commonly used surfactants
and dispersing agents used in the formulation of MDIs.
There are several MDIs formulated with this propellant worldwide
that contain a steroid as the active ingredient.
Safety
Heptafluoropropane is used as a fire extinguisher and is applicable as a non-CFC propellant in various metered-dose inhalers. Heptafluoropropane is regarded as nontoxic and nonirritating when used as directed. No acute or chronic hazard is present when it is used normally. Inhaling high concentrations of heptafluoropropane vapors can be harmful and is similar to inhaling vapors of other propellants. Deliberate inhalation of vapors of heptafluoropropane can be dangerous and may cause death. The same labeling required of CFC aerosols would be required for those containing heptafluoropropane as a propellant (except for the EPA requirement).
storage
Heptafluoropropane is a nonreactive and stable material. The liquefied gas is stable when used as a propellant and should be stored in a metal cylinder in a cool, dry place.
1,1,1,2,3,3,3-Heptafluoropropane Preparation Products And Raw materials
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