ChemicalBook
Chinese Japanese Germany Korea

1,1,1,2,3,3,3-Heptafluoropropane

1,1,1,2,3,3,3-Heptafluoropropane
1,1,1,2,3,3,3-Heptafluoropropane structure
CAS No.
431-89-0
Chemical Name:
1,1,1,2,3,3,3-Heptafluoropropane
Synonyms
R227;R227ea;FM-200;R 227ea;HFC-227;hfc-227ea;khladon227;Apaflurane;Freons R227;apaflurane(INN)
CBNumber:
CB4692270
Molecular Formula:
C3HF7
Formula Weight:
170.03
MOL File:
431-89-0.mol

1,1,1,2,3,3,3-Heptafluoropropane Properties

Melting point:
-126.8°C
Boiling point:
-16.4°C
Density 
1,409 g/cm3
refractive index 
1.2747 (estimate)
solubility 
Soluble 1 in 1725 parts of water at 20°C.
Stability:
Stable. Incompatible with strong oxidizing agents, alkali metals
CAS DataBase Reference
431-89-0(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
R40P36GDK6
NIST Chemistry Reference
1,1,1,2,3,3,3-Heptafluoropropane(431-89-0)
EPA Substance Registry System
HFC-227ea (431-89-0)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Safety Statements  23-38
RIDADR  3296
Hazard Note  Irritant
HazardClass  2.2
NFPA 704
0
1 1

1,1,1,2,3,3,3-Heptafluoropropane Chemical Properties,Uses,Production

Chemical Properties

Heptafluoropropane is a liquefied gas and exists as a liquid at room temperature when contained under its own vapor pressure, or as a gas when exposed to room temperature and atmospheric pressure. The liquid is practically odorless and colorless. The gas in high concentration has a faint etherlike odor. Heptafluoropropane is noncorrosive, nonirritating, and nonflammable.

Uses

HFC 227ea is being developed as a CFC replacement in refrigerants, high temperature heat pumps, air-conditioning systems; as a fire suppressant; and for pharmaceutical aerosols and metered-dose inhalers.

Pharmaceutical Applications

Heptafluoropropane is classified as a hydrofluorocarbon (HFC) aerosol propellant since the molecule consists only of carbon, fluorine, and hydrogen atoms. It does not contain any chlorine and consequently does not affect the ozone layer, nor does it have an effect upon global warming. It is therefore considered as an alternative propellant to CFCs for metered-dose inhalers (MDIs). While some of its physical and chemical properties are known, little has been published in regard to its use as a replacement for CFCs in MDIs.
The vapor pressure of heptafluoropropane is somewhat lower than that of tetrafluoroethane and dichlorodifluoromethane but considerably higher than the vapor pressure used to formulate most MDIs.
When heptafluoropropane is used for pharmaceutical aerosols and MDIs, the pharmaceutical grade must be specified. Industrial grades may not be suitable due to their impurity profile. Similarly to tetrafluoroethane, heptafluoropropane is not a good solvent for medicinal agents or for the commonly used surfactants and dispersing agents used in the formulation of MDIs.
There are several MDIs formulated with this propellant worldwide that contain a steroid as the active ingredient.

Safety

Heptafluoropropane is used as a fire extinguisher and is applicable as a non-CFC propellant in various metered-dose inhalers. Heptafluoropropane is regarded as nontoxic and nonirritating when used as directed. No acute or chronic hazard is present when it is used normally. Inhaling high concentrations of heptafluoropropane vapors can be harmful and is similar to inhaling vapors of other propellants. Deliberate inhalation of vapors of heptafluoropropane can be dangerous and may cause death. The same labeling required of CFC aerosols would be required for those containing heptafluoropropane as a propellant (except for the EPA requirement).

storage

Heptafluoropropane is a nonreactive and stable material. The liquefied gas is stable when used as a propellant and should be stored in a metal cylinder in a cool, dry place.

1,1,1,2,3,3,3-Heptafluoropropane Preparation Products And Raw materials

Raw materials

Preparation Products


1,1,1,2,3,3,3-Heptafluoropropane Suppliers

Global( 102)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Zjartschem
+86-571-8723 8903 jocelynpan@zjarts.com
+86-571-87063838 jocelynpan@zjarts.com CHINA 997 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21022 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29959 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47496 58
BEYOND INDUSTRIES (CHINA) LIMITED
+8613917686115
+862162570268 sales@beyondindustriesgroup.com CHINA 704 58
Allfluoro pharmaceutical co. ltd.
0086-21-26137118
0086-21-33275002 sales@allfluoro.com CHINA 5812 58

View Lastest Price from 1,1,1,2,3,3,3-Heptafluoropropane manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-06 1,1,1,2,3,3,3-Heptafluoropropane
431-89-0
US $1.00 / KG 1G 98% 100KG career henan chemical co

431-89-0(1,1,1,2,3,3,3-Heptafluoropropane)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved