Endothelin-1 (human, porcine)
- CAS No.
- 117399-94-7
- Chemical Name:
- Endothelin-1 (human, porcine)
- Synonyms
- Endothelin;ET-1;ENDOTHELIN 1;ET-1, HUMAN;Endothelin 1【pig】;Endotherin 1【rat】;ENDOTHELIN-1(HUMAN);Endotherin 1【mouse】;ET-1, HUMAN, PORCINE;Endothelin 1【canine】
- CBNumber:
- CB4706533
- Molecular Formula:
- C109H159N25O32S5
- Molecular Weight:
- 2491.9
- MDL Number:
- MFCD00133305
- MOL File:
- 117399-94-7.mol
- MSDS File:
- SDS
| Boiling point | 2467.3±65.0 °C(Predicted) |
|---|---|
| Density | 1.273±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | 1% acetic acid: >1 mg/mL |
| form | powder |
| color | white |
| Water Solubility | Soluble in water. |
| Merck | 13,3610 |
| InChIKey | ZUBDGKVDJUIMQQ-UHFFFAOYSA-N |
| FDA UNII | 2K62B8Z6XF |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300+H330 |
| Precautionary statements | P260-P264-P270-P271-P284-P304+P340+P310 |
| WGK Germany | 3 |
| RTECS | KE9446500 |
| F | 3-10 |
| HS Code | 2937190000 |
Endothelin-1 (human, porcine) price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E7764 | Endothelin 1 ≥97% (HPLC), powder | 117399-94-7 | 10μg | $64.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | E7764 | Endothelin 1 ≥97% (HPLC), powder | 117399-94-7 | 50μg | $210 | 2024-03-01 | Buy |
| Sigma-Aldrich | E7764 | Endothelin 1 ≥97% (HPLC), powder | 117399-94-7 | 0.1mg | $360 | 2024-03-01 | Buy |
| Sigma-Aldrich | 05-23-3800 | Endothelin 1, Human and Porcine Endothelin 1, Human and Porcine, CAS 117399-94-7, is a 21-amino acid polypeptide with potent vasoconstrictive action. Activates phospholipase C in fibroblasts expressing ETA receptors. | 117399-94-7 | 0.1MG | $175 | 2024-03-01 | Buy |
| Sigma-Aldrich | 05-23-3800 | Endothelin 1, Human and Porcine Endothelin 1, Human and Porcine, CAS 117399-94-7, is a 21-amino acid polypeptide with potent vasoconstrictive action. Activates phospholipase C in fibroblasts expressing ETA receptors. | 117399-94-7 | 0.5MG | $521 | 2024-03-01 | Buy |
Endothelin-1 (human, porcine) Chemical Properties,Uses,Production
Description
Endothelin-1 (human, porcine) is an active peptide with strong vasoconstriction effect isolated from the supernatant of cultured porcine aortic endothelial cells. Endothelin 1 has been shown to be present in many mammals, including humans. Although vascular endothelial cells are the main source of endothelin 1, cardiomyocytes, vascular smooth muscle cells, renal tubular epithelial cells and glial cells can all produce endothelin 1, suggesting that endothelin 1 can independently participate in the complex regulatory mechanism of various organs.
Uses
Endothelin-1 (human, porcine) has been used for coating wells in polystyrene ELISA plates. Potent agonist for ETA and ETB endothelia receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF.
Biological Functions
Endothelins are a family of vasoactive peptides secreted by endothelial cells. The three major endothelin peptides are all composed of 21 amino acids. Endothelins are the most potent vasoconstrictors known. Contraction of vascular smooth muscle in response to endothelin is associated with an increase in intracellular calcium. Increases in endothelin levels have been reported in patients with vasospastic, hypoxic, and ischemic diseases.The two identified isoforms of endothelin receptors have differing affinity for the three endothelin peptides. Selective and nonselective endothelin receptor antagonists are in development for potential use in the treatment of hypertension and other disorders associated with increased vascular resistance.
Biological Activity
Endothelin 1 (human, porcine) is an endogenous potent vasoconstrictor peptide that is an agonist at ETA and ETB receptors. Modulates vascular tone. Endothelin-1 (ET-1) is a potent vasoconstrictor peptide isolated from porcine endothelial cells. ET-1 is widely present at binding sites in blood vessels, heart, kidneys, adrenal glands, lungs, and brain, and its distribution is similar to endothelial cells.
Biochem/physiol Actions
Potent agonist for ETA and ETB endothelin receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF.
storage
-20°C (desiccate)
Endothelin-1 (human, porcine) Preparation Products And Raw materials
Raw materials
Preparation Products
Endothelin-1 (human, porcine) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 999 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12527 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
View Lastest Price from Endothelin-1 (human, porcine) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-13 | ENDOTHELIN 1 HUMAN, PORCINE
117399-94-7
|
US $7.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- ENDOTHELIN 1 HUMAN, PORCINE
117399-94-7
- US $7.00 / KG
- 99%
- Career Henan Chemical Co