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CALPEPTIN

CALPEPTIN structure

CAS No.: 117591-20-5

Chemical Name:: CALPEPTIN

Synonyms: CS-1747;CALPEPTIN;Z-LEU-NLE-OH;Calpeptin,95%;Z-LEU-NLE-CHO;Z-LEU-NORLEUCINAL;N-CBZ-L-LEUCYL-NORLEUCINAL;BENZYLOXYCARBONYLLEUCYL-NORLEUCINAL;BENZYLOXYCARBONYLDIPEPTIDYL ALDEHYDE;N-BENZYLOXYCARBONYL-L-LEUCYLNORLEUCINAL

CBNumber:: CB4713515

Molecular Formula:: C20H30N2O4

Molecular Weight:: 362.46

MDL Number:: MFCD00155623

MOL File:: 117591-20-5.mol

MSDS File:: SDS

Last updated:2023-07-14 17:44:35

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CALPEPTIN Properties

Melting point	60-75 °C
Boiling point	494.07°C (rough estimate)
Density	1.1667 (rough estimate)
refractive index	1.6800 (estimate)
storage temp.	-20°C
solubility	Soluble in DMSO at 15mg/ml
form	White to off-white solid
pka	11.14±0.46(Predicted)
color	white to beige
InChIKey	PGGUOGKHUUUWAF-ROUUACIJSA-N
CAS DataBase Reference	117591-20-5(CAS DataBase Reference)
FDA UNII	18X9FR245W

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338
Safety Statements	24/25
WGK Germany	3
HS Code	29242990

CALPEPTIN price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	03-34-0051	Calpeptin - CAS 117591-20-5 - Calbiochem A cell-permeable calpain inhibitor (ID?? = 52 nM for calpain-1; ID?? = 34 nM for calpain-2; ID?? = 138 nM for papain).	117591-20-5	5mg	$144	2024-03-01	Buy
Sigma-Aldrich	03-34-0051	Calpeptin - CAS 117591-20-5 - Calbiochem A cell-permeable calpain inhibitor (ID?? = 52 nM for calpain-1; ID?? = 34 nM for calpain-2; ID?? = 138 nM for papain).	117591-20-5	25mg	$373	2024-03-01	Buy
Sigma-Aldrich	03-34-0051	Calpeptin - CAS 117591-20-5 - Calbiochem A cell-permeable calpain inhibitor (ID?? = 52 nM for calpain-1; ID?? = 34 nM for calpain-2; ID?? = 138 nM for papain).	117591-20-5	100mg	$1070	2024-03-01	Buy
Alfa Aesar	J60481	Calpeptin, 98+%	117591-20-5	10mg	$220	2023-06-20	Buy
Alfa Aesar	J60481	Calpeptin, 98+%	117591-20-5	50mg	$807	2021-12-16	Buy

Product number	Packaging	Price	Buy
03-34-0051	5mg	$144	Buy
03-34-0051	25mg	$373	Buy
03-34-0051	100mg	$1070	Buy
J60481	10mg	$220	Buy
J60481	50mg	$807	Buy

CALPEPTIN Chemical Properties,Uses,Production

Chemical Properties

white to off-white powder

Uses

Calpeptin is used to to inhibit the activities of cathepsin L and calpain-1. Calpeptin blocked the expression of aspartyl protease cathepsin D, amyloid precursor protein, and calparin. It acts as an inhibitor of the Ca2+-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. It is shown to preferentially inhibit a subset of protein-tyrosine phosphatases.

Definition

ChEBI: Calpeptin is an amino acid amide.

General Description

Calpeptin (Z-Leu-nLeu-H) is a cell permeable, peptide aldehyde inhibitor. It is more sensitive to calpain I compared to other inhibitors, such as Z-Leu-Met-H and leupeptin. Calpeptin stimulates neurite elongation in differentiating pheochromocytoma (PC12) cells. Calpeptin decreases microgliosis, astrogliosis, axonal damage and neuron and oligodendrocyte death in experimental autoimmune encephalomyelitis (EAE) spinal cord. Therefore, it can be considered as a potent therapeutic for treating EAE and multiple sclerosis (MS).

Biological Activity

Potent, cell-permeable inhibitor of the Ca 2+ -dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. Recently shown to preferentially inhibit a subset of protein-tyrosine phosphatases.

Biochem/physiol Actions

Calpeptin is a rho kinase activator and an inhibitor of calpains, a family of calcium-dependent cysteine proteases involved in apoptosis, long-term potentiation in neurons, and cell cycle progression.

in vitro

calpeptin reduced production of tgf-b1, il-6, angiopoietin-1 and collagen synthesis from lung fibroblasts. calpeptin also reduced both angiopoietin-1-dependent migration and il-6-dependent proliferation of the cells, which could be the underlying mechanism of the preventive effect of calpeptin on pulmonary fibrosis [1].

in vivo

the preventive effect of calpeptin has been examined on bleomycin-induced pulmonary fibrosis in mice. histological examinations and quantitative measurements of related proteins in bleomycin-treated mouse lung tissues with or without calpeptin were performed. calpeptin histologically ameliorated bleomycininduced pulmonary fibrosis in mice. results showed that calpeptin decreased the expression of il-6, tgf-b1, angiopoietin-1 and collagen type ia1 mrna in mouse lung tissues [1].

IC 50

5 nm for human calpain 1

storage

Desiccate at +4°C

References

[1] tabata c,tabata r,nakano t. the calpain inhibitor calpeptin prevents bleomycin-induced pulmonary fibrosis in mice. clin exp immunol.2010 dec;162(3):560-7.

CALPEPTIN synthesis

Synthesis of CALPEPTIN from N-Cbz-L-Leucine

CALPEPTIN Preparation Products And Raw materials

Raw materials

N-Cbz-L-Leucine L-NORLEUCINOL

Preparation Products

CALPEPTIN Suppliers

Global( 109)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58

Supplier	Advantage
Alpha Biopharmaceuticals Co., Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58
BOC Sciences	58
Career Henan Chemica Co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
Nextpeptide Inc	58
InvivoChem	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58

CALPEPTIN Spectrum

CALPEPTIN(117591-20-5)¹HNMR

117591-20-5(CALPEPTIN)Related Search:

3-METHYLADENINE YM155 (Sepantronium Bromide) Ifosfamide Necrostatin-1 PCI 34051

Mocetinostat (MGCD0103) H-LEU-NLE-OH Ac-Leu-Leu-Nle-OH Z-LEU-NLE-OH H-LEU-LEU-NLE-OH

H-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-NLE-OH CALPEPTIN Z-LEU-NH2 Z-L-LEUCYL-L-ALANINE

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CALPEPTIN BENZYLOXYCARBONYLLEUCYL-NORLEUCINAL BENZYLOXYCARBONYLDIPEPTIDYL ALDEHYDE N-CBZ-L-LEUCYL-NORLEUCINAL N-BENZYLOXYCARBONYL-L-LEUCYLNORLEUCINAL Z-LEU-NLE-CHO Z-LEU-NLE-OH Z-LEU-NORLEUCINAL N-[N-[(Phenylmethoxy)carbonyl]-L-leucyl]-L-norleucinal Calpeptin,95% CalpeptinN-Benzyloxycarbonyl-L-leucyl-norleucinal CarbaMic acid, [(1S)-1-[[[(1S)-1-forMylpentyl]aMino]carbonyl]-3-Methylbutyl]-, phenylMethyl ester benzyl (S)-4-methyl-1-oxo-1-((S)-1-oxohexan-2-ylamino)pentan-2-ylcarbamate N-[(1S)-1-[[(1S)-1-Formylpentyl]Carbamoyl]-3-Methyl-Butyl]Carbamic Acid Be N-[(1S)-1-[[[(1S)-1-Formylpentyl]Amino]-Oxomethyl]-3-Methylbutyl]Carbamic Acid Phenylmethyl Ester Phenylmethyl N-[(1S)-1-[[(1S)-1-Formylpentyl]Carbamoyl]-3-Methyl-Butyl]Carbamate N-Benzyloxycarbonyl-L-leucylnorieucinal Z-LEU-NORLEUCINAL;N-BENZYLOXYCARBONYL-L-LEUCYL-NORLEUCINAL Calpeptin - CAS 117591-20-5 - Calbiochem CALPEPTIN【benzyl ((2S,4S)-6-methyl-3-oxo-2-((R)-1-oxohexan-2-yl)piperidin-4-yl)carbamate】 CS-1747 Carbamic acid, N-[(1S)-1-[[[(1S)-1-formylpentyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester 117591-20-5 11759-20-5 C20H30N2O4 Inhibitors Calcium signaling