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Tiaprofenic acid

CAS No.
33005-95-7
Chemical Name:
Tiaprofenic acid
Synonyms
Surgam;FC 3001;Suralgan;RU 15060;Tiaprofen;Surgam SA;Tiaprofenic;TiaprofenicAci;Tiaprofensaeure;Tiaprofenic acid
CBNumber:
CB4875253
Molecular Formula:
C14H12O3S
Molecular Weight:
260.31
MDL Number:
MFCD00866089
MOL File:
33005-95-7.mol
MSDS File:
SDS
Last updated:2023-08-15 17:37:19

Tiaprofenic acid Properties

Melting point 96° (isopropyl ether)
Boiling point 373.57°C (rough estimate)
Density 1.2959 (rough estimate)
refractive index 1.5050 (estimate)
storage temp. 2-8°C(protect from light)
solubility Practically insoluble in water, freely soluble in acetone, in ethanol (96 per cent) and in methylene chloride.
pka 4.05±0.10(Predicted)
color White to Almost white
λmax 314nm(Phosphate buffer sol.)(lit.)
Merck 14,9422
EWG's Food Scores 1
FDA UNII 1LS1T6R34C
ATC code M01AE11

Pharmacokinetic data

Protein binding 97-98%
Excreted unchanged in urine 50 (10% as metabolites)
Volume of distribution 5.4-6.7 Litres
Biological half-life 1.5-2 / -

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H361
Precautionary statements  P201-P301+P310+P330
RIDADR  UN 2811 6.1/PG III
RTECS  XM7580000
HS Code  2934.99.3000
HazardClass  6.1
PackingGroup  III
NFPA 704
0
2 0

Tiaprofenic acid price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T1410900 Tiaprofenic acid European Pharmacopoeia (EP) Reference Standard 33005-95-7 t1410900 $150 2024-03-01 Buy
TCI Chemical T3175 Tiaprofenic Acid >98.0%(GC)(T) 33005-95-7 25mg $150 2024-03-01 Buy
TCI Chemical T3175 Tiaprofenic Acid >98.0%(GC)(T) 33005-95-7 100mg $452 2024-03-01 Buy
Cayman Chemical 27364 Tiaprofenic Acid 33005-95-7 10mg $61 2024-03-01 Buy
Cayman Chemical 27364 Tiaprofenic Acid 33005-95-7 100mg $396 2024-03-01 Buy
Product number Packaging Price Buy
T1410900 t1410900 $150 Buy
T3175 25mg $150 Buy
T3175 100mg $452 Buy
27364 10mg $61 Buy
27364 100mg $396 Buy

Tiaprofenic acid Chemical Properties,Uses,Production

Chemical Properties

White or almost white, crystalline powder.

Originator

Surgam,Roussel,France,1975

Uses

Antiinflammatory;Cyclooxygenase inhibitor

Definition

ChEBI: An aromatic ketone that is thiophene substituted at C-2 by benzoyl and at C-4 by a 1-carboxyethyl group.

Manufacturing Process

A mixture of 10.3 g of thiophene-2α-methylacetic acid [prepared by process of Bercot-Vatteroni, et al., Bull. Soc. Chim. (1961) pp. 1820-21], 11.10 g of benzoyl chloride and a suspension of 23.73 g of aluminum chloride in 110 cc of chloroform was allowed to stand for 15 minutes and was then poured into a mixture of ice and hydrochloric acid. The chloroform phase was extracted with a 10% aqueous potassium carbonate solution and the aqueous alkaline phase was acidified with N hydrochloric acid and was then extracted with ether. The ether was evaporated off and the residue was crystallized from carbon tetrachloride to obtain a 54% yield of 5-benzoyl-thiophene-2α-methylacetic acid melting at 83°C to 85°C. The product occurred in the form of colorless crystals soluble in dilute alkaline solutions, alcohol and ether and insoluble in water.

Therapeutic Function

Antiinflammatory

Drug interactions

Potentially hazardous interactions with other drugs
ACE inhibitors and angiotensin-II antagonists: antagonism of hypotensive effect; increased risk of nephrotoxicity and hyperkalaemia.
Analgesics: avoid concomitant use of 2 or more NSAIDs, including aspirin (increased side effects); avoid with ketorolac (increased risk of side effects and haemorrhage).
Antibacterials: possibly increased risk of convulsions with quinolones.
Anticoagulants: effects of coumarins and phenindione enhanced; possibly increased risk of bleeding with heparins, dabigatran and edoxaban - avoid long term use with edoxaban.
Antidepressants: increased risk of bleeding with SSRIs and venlaflaxine.
Antidiabetic agents: effects of sulphonylureas enhanced.
Antiepileptics: possibly increased phenytoin concentration.
Antivirals: increased risk of haematological toxicity with zidovudine; concentration increased by ritonavir.
Ciclosporin: may potentiate nephrotoxicity.
Cytotoxics: reduced excretion of methotrexate; increased risk of bleeding with erlotinib.
Diuretics: increased risk of nephrotoxicity; antagonism of diuretic effect; hyperkalaemia with potassium-sparing diuretics.
Lithium: excretion decreased.
Pentoxifylline: increased risk of bleeding.
Tacrolimus: increased risk of nephrotoxicity.

Metabolism

Sparingly metabolised in the liver to two inactive metabolites. Excretion of tiaprofenic acid and its metabolites are mainly in the urine in the form of acyl glucuronides; some is excreted in the bile.

Tiaprofenic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 110)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd
+8613288715578 sales@hbmojin.com China 12452 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2989 55
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 alice@crovellbio.com China 8823 58
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569265 +86-18612256290 1056@dideu.com China 3959 58
SIMAGCHEM CORP
+86-13806087780 sale@simagchem.com China 17368 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671 sales@tnjchem.com China 34572 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58

View Lastest Price from Tiaprofenic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tiaprofenic acid pictures 2023-08-15 Tiaprofenic acid
33005-95-7
US $20.00 / KG 1KG 99% 500000KG Hebei Mojin Biotechnology Co., Ltd
Tiaprofenic acid pictures 2023-06-15 Tiaprofenic acid
33005-95-7
US $667.00 / KG 1KG 99% 100kg Baoji Guokang Bio-Technology Co., Ltd.
Tiaprofenic acid pictures 2023-03-09 Tiaprofenic acid
33005-95-7
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
  • Tiaprofenic acid pictures
  • Tiaprofenic acid
    33005-95-7
  • US $667.00 / KG
  • 99%
  • Baoji Guokang Bio-Technology Co., Ltd.
  • Tiaprofenic acid pictures
  • Tiaprofenic acid
    33005-95-7
  • US $10.00 / KG
  • 99%
  • Hebei Guanlang Biotechnology Co., Ltd.
TIAPROFENIC ACID EPT(CRM STANDARD) Tiaprofenic (RS)-Tiaprofenic acid 2-Thiopheneacetic acid, 5-benzoyl-a-methyl- (8CI, 9CI) FC 3001 RU 15060 Suralgan Surgam Tiaprofen 2-[5-(Phenylcarbonyl)-2-thienyl]propanoic acid Tiaprofenic acid 5-BENZOYL-α-METHYL-2-THIOPHENEACETIC ACID 2-(5-Benzyl-2-thienyl)propionsaeure 2-Thiopheneacetic acid, 5-benzoyl-alpha-methyl- 5-Benzoyl-alpha-methyl-2-thiopheneacetic acid Acide tiaprofenique Acide tiaprofenique [inn-french] Acido tiaprofenico Acido tiaprofenico [inn-spanish] Acidum tiaprofenicum α-(5-Benzoyl-2-thienyl)propionic Acid Surgam SA 2-(5-benzoylthiophen-2-yl)propanoic acid Tiaprofenic acid CRS Tiaprofensaeure 2-Thiopheneacetic acid, 5-benzoyl-α-methyl- (2RS)-2-(5-Benzoylthiophen-2-yl)propanoic acid TiaprofenicAci 2-(5-Benzoylthiophen-2-yl)propionic Acid Tiaprofenic acid USP/EP/BP Tiaprofenic acid 13C6 5-benzoyl-a-methyl-2-Thiopheneacetic acid 33005-95-7