2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one monohydrochloride
![2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one monohydrochloride Structure](CAS/GIF/57775-22-1.gif)
- CAS No.
- 57775-22-1
- Chemical Name:
- 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one monohydrochloride
- Synonyms
- Staff;Etonin;Etoran;Tropene;Axiomin;ST-1191;Deprecer;Depracer;NSC304398;NSC 304398
- CBNumber:
- CB4930927
- Molecular Formula:
- C19H29Cl2N5O
- Molecular Weight:
- 414.37246
- MDL Number:
- MFCD01678245
- MOL File:
- 57775-22-1.mol
2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one monohydrochloride Properties
| Melting point | 197-198° |
|---|---|
| solubility | soluble in Methanol, Water |
| form | Solid |
| color | White |
| FDA UNII | 2FSU2FR80J |
SAFETY
Risk and Safety Statements
| Toxicity | LD50 in mice, rats (mg/kg): 580, 720 orally; 72, 62 i.v.; 135, 120 i.p. (Lisciani) |
|---|
2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one monohydrochloride price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | E933680 | EtoperidoneHydrochloride | 57775-22-1 | 50mg | $685 | 2021-12-16 | Buy |
| TRC | E933680 | EtoperidoneHydrochloride | 57775-22-1 | 100mg | $1260 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0172520 | 2-[3-[4-(3-CHLOROPHENYL)PIPERAZIN-1-YL]PROPYL]-4,5-DIETHYL-2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE MONOHYDROCHLORIDE 95.00% | 57775-22-1 | 1MG | $337.05 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0172520 | 2-[3-[4-(3-CHLOROPHENYL)PIPERAZIN-1-YL]PROPYL]-4,5-DIETHYL-2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE MONOHYDROCHLORIDE 95.00% | 57775-22-1 | 5MG | $503.16 | 2021-12-16 | Buy |
2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one monohydrochloride Chemical Properties,Uses,Production
Chemical Properties
White Solid
Originator
Etoperidone,ZYF Pharm
Uses
A psychotropic drug related structurally to trazodone. Antidepressant.
Manufacturing Process
(a). 3,4-Diethyl-δ2-1,2,4-triazolin-5-one (62 g) is dissolved in anhydrous
dioxane (about 500 ml) and NaH (21 g) in a 50 percent oily suspension is
added. The solution is heated for 30 min under reflux and NmetachlorophenyI-
N'-(3-chloro-n-propyl)piperazine (119 g) is added under
stirring. The solution is heated for 20 hours under reflux. The solvent is then
eliminated under reduced pressure and the residue is treated with 2 N HCl.
The solution is washed with ether so as to eliminate the oil present in the
hydride solution, and made alkaline with 50% K2CO3. It is extracted with
ether and dried, the solvent is eliminated and the residue is distilled under
reduced pressure. 115 g of 2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-
4,5-diethyl-2,4-dihydro-1,2,4-triazol-3-one are obtained. B.P. 230°C/0.5 mm.
2-(3-(4-(3-Chlorophenyl)-1-piperazinyl)propyl)-4,5-diethyl-2,4-dihydro-1,2,4-
triazol-3-one hydrochloride was prepared by standard procedures, melting
point 197-198°C (recrystallization from isopropanol).
(b). 3,4-Diethyl-δ2-1,2,4-triazolin-5-one (1 g) and 3-bromo-1-chloropropane
(6.6 g) are added to a solution of Na (0.98 g) in methanol (20 ml). The
solution is refluxed until the pH becomes neutral, poured into water, extracted
with ether. The solvent is eliminated and the residual oil is distilled. 1-(3-
Chloropropyl)-3,4-diethyl-δ2-1,2,4-triazolin-5-one boils at 121°C/0.05 mm.
1-(3-Chloropropyl)-3,4-diethyl-δ2-1,2,4-triazolin-5-one (1.0 g), NmetachlorophenyIpiperazine
(0.9 g) and triethylamine (0.46 g) in toluene (25
ml) are refluxed for 12 hours. The solution is treated with 5 N NaOH,
extracted with ether and steam-distilled. The residue is extracted with ether
and the ethereal solution is treated with ethereal HCl. 2-(3-(4-(3-
Chlorophenyl)-1-piperazinyl)propyl)-4,5-diethyl-2,4-dihydro-1,2,4-triazol-3-
one hydrochloride has melting point 197-198°C (recrystallization from
isopropanol).
Therapeutic Function
Antidepressant, Anxiolytic
2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one monohydrochloride Preparation Products And Raw materials
2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one monohydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |