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Lomustine

Lomustine
Lomustine structure
CAS No.
13010-47-4
Chemical Name:
Lomustine
Synonyms
CCNU;cinu;ceenu;cecenu;rb1509;sri2200;icig1109;Lomustin;nsc79037;LOMUSTINE
CBNumber:
CB5123021
Molecular Formula:
C9H16ClN3O2
Formula Weight:
233.7
MOL File:
13010-47-4.mol

Lomustine Properties

Melting point:
88-90
Boiling point:
63.6°C (rough estimate)
Density 
1.3840 (rough estimate)
refractive index 
1.5790 (estimate)
storage temp. 
−20°C
solubility 
Practically insoluble in water, freely soluble in acetone and in methylene chloride, soluble in ethanol (96 per cent).
form 
neat
Merck 
14,5564
InChIKey
GQYIWUVLTXOXAJ-UHFFFAOYSA-N
CAS DataBase Reference
13010-47-4(CAS DataBase Reference)
EPA Substance Registry System
Urea, N-(2-chloroethyl)-N'- cyclohexyl-N-nitroso-(13010-47-4)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H340-H360-H370-H371-H372-H373-H301-H350
Precautionary statements  P201-P280-P308+P313-P301+P310-P202-P260-P264-P270-P301+P310+P330-P307+P311-P405-P501
Hazard Codes  T
Risk Statements  45-25
Safety Statements  53-45
RIDADR  3249
WGK Germany  3
RTECS  YS4900000
HazardClass  6.1(a)
PackingGroup  II
HS Code  29299090
Toxicity LD50 in male mice (mg/kg): 51 orally; 56 i.p.; 61 s.c. (Thompson, Larson)

Lomustine price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L5918 Lomustine ≥98% 13010-47-4 100mg $120 2018-11-20 Buy
Sigma-Aldrich 1369419 Lomustine United States Pharmacopeia (USP) Reference Standard 13010-47-4 200mg $352.8 2018-11-20 Buy
TCI Chemical L0251 Lomustine >98.0%(HPLC) 13010-47-4 1g $500 2018-11-22 Buy
TCI Chemical L0251 Lomustine >98.0%(HPLC) 13010-47-4 200mg $143 2018-11-22 Buy
Cayman Chemical 21237 Lomustine ≥98% 13010-47-4 50mg $29 2018-11-19 Buy

Lomustine Chemical Properties,Uses,Production

Chemical Properties

Lomustine is a pale yellow powder.

Uses

Chloroethylnitrosourea derivative with antitumor activity. Similar to carmustine, chlorozotocin, nimustine, ranimustine. Antineoplastic.

Uses

CCNU is an oral anticancer drug that was approved by the U.S. Food and Drug Administration in 1976 for marketing, as lomustine (FDA 2009a). CCNU is used alone or in combination with other antineoplastic agents, including procarbazine and vincristine, etoposide and prednimustine, and other combinations (IARC 1981, HSDB 2009). It is used primarily in the treatment of Hodgkin’s disease and brain tumors, but it has also been used to treat other cancer, includ-ing lung cancer, non-Hodgkin’s lymphoma, malignant melanoma, breast cancer, kidney cancer, and cancer of the gastrointestinal tract (MedlinePlus 2009). It has also been applied to the skin to treat mycosis fungoides and psoriasis.

Definition

ChEBI: An N-nitrosourea that is urea in which one of the nitrogens is substituted by a 2-chloroethyl group and by a nitroso group, while the other nitrogen is substituted by a cyclohexyl group. An alkylating antineoplastic agent, it is used in he treatment of brain tumours, lung cancer, malignant melanoma and other solid tumours.

brand name

Ceenu (Bristol-Myers Squibb).

General Description

Lomustine is available in 10-, 40-, and 100-mg capsules fororal administration in the treatment of primary and metastaticbrain cancers and Hodgkin’s lymphoma. This lipophilicagent is well absorbed, widely distributed, and crosses theblood-brain barrier. Lomustine undergoes extensive hepaticmetabolism, which is mediated by CYP3A4 to give severalhydroxylated metabolites, which arise as a result of oxidationof the cyclohexyl ring. Several of these are more activethan the parent compound. Denitrosation and dechlorinationhave also been demonstrated to occur for lomustine as well.The intact drug was not found in plasma when the agent wasadministered orally. Elimination occurs primarily in theurine with an elimination half-life of 16 to 72 hours.Myelosuppression is dose limiting and presents in a mannersimilar to that seen with carmustine. Other toxicities includenausea, vomiting, anorexia, impotence, sterility, amenorrhea,and infertility. Pulmonary and renal toxicity are rarelyseen during standard-dose therapy but increase during highdosetherapy.

Safety Profile

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by ingestion, intraperitoneal, subcutaneous, intravenous, and possibly other routes. Human systemic effects by ingestion: anorexia, nausea or vomiting, leukopenia (decrease in the white blood cell count), and thrombocytopenia (decrease in the number of blood platelets). Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx. See also NNITROSO COMPOUNDS.

Potential Exposure

A potential danger to those involved in the manufacture, administration or consumption of this antineoplastic (anti-cancer) agent

Veterinary Drugs and Treatments

Lomustine may be useful in the adjunctive treatment of CNS neoplasms, lymphomas, and mast cell tumors in dogs and cats.

Carcinogenicity

1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Waste Disposal

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Regulations

Consumer Product Safety Commission (CPSC)
Any orally administered prescription drug for human use requires child-resistant packaging.
Food and Drug Administration (FDA)
Lomustine is a prescription drug subject to labeling and other requirements.

Lomustine Preparation Products And Raw materials

Raw materials

Preparation Products


Lomustine Suppliers

Global( 228)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21676 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 3195 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8921 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6372 58

View Lastest Price from Lomustine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Lomustine
13010-47-4
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-08-08 Lomustine
13010-47-4
US $1.00 / KG 1KG 98% 1tons career henan chemical co

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