2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-,methylester(9CI)
- CAS No.
- 443912-70-7
- Chemical Name:
- 2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-,methylester(9CI)
- Synonyms
- Methyl 4-Methyltetrahydro...;Methyl 4-Methyloxane-4-carboxylate;Methyl 4-Methyltetrahydropyran-4-carboxylate;4-methyl-4-oxanecarboxylic acid methyl ester;Methyl 4-Methyltetrahydro-2H-pyran-4-carboxylate;methyl tetrahydro-4-methyl-2H-pyran-4-carboxylate;4-Methyltetrahydropyran-4-carboxylic acid methyl ester;Tetrahydro-4-methyl-2H-pyran-4-carboxylic acid methyl ester;2H-Pyran-4-carboxylic acid, tetrahydro-4-methyl-, methyl ester;2H-Pyran-4-carboxylicacid, tetrahydro-4-methyl-, methyl este...
- CBNumber:
- CB51271268
- Molecular Formula:
- C8H14O3
- Molecular Weight:
- 158.2
- MDL Number:
- MFCD12912101
- MOL File:
- 443912-70-7.mol
| Product description | Number | Pack Size | Price |
| Methyl4-Methyltetrahydro-2H-pyran-4-carboxylate | M219565 | 100mg | $60 |
| Methyl4-methyltetrahydro-2H-pyran-4-carboxylate | 2H23-1-48 | 1g | $125 |
| Methyl4-methyltetrahydro-2H-pyran-4-carboxylate | 6112AB | 1g | $151 |
| Methyl4-methyltetrahydro-2H-pyran-4-carboxylate 98% | OR926394 | 1g | $170 |
| Methyl 4-methyltetrahydro-2H-pyran-4-carboxylate | 113084 | 1g | $356 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| HS Code | 2932990090 |
2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-,methylester(9CI) price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M219565 | Methyl4-Methyltetrahydro-2H-pyran-4-carboxylate | 443912-70-7 | 100mg | $60 | 2021-12-16 | Buy |
| SynQuest Laboratories | 2H23-1-48 | Methyl4-methyltetrahydro-2H-pyran-4-carboxylate | 443912-70-7 | 1g | $125 | 2021-12-16 | Buy |
| AK Scientific | 6112AB | Methyl4-methyltetrahydro-2H-pyran-4-carboxylate | 443912-70-7 | 1g | $151 | 2021-12-16 | Buy |
| Apolloscientific | OR926394 | Methyl4-methyltetrahydro-2H-pyran-4-carboxylate 98% | 443912-70-7 | 1g | $170 | 2021-12-16 | Buy |
| Matrix Scientific | 113084 | Methyl 4-methyltetrahydro-2H-pyran-4-carboxylate | 443912-70-7 | 1g | $356 | 2021-12-16 | Buy |
2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-,methylester(9CI) Chemical Properties,Uses,Production
Synthesis
110238-91-0
74-88-4
443912-70-7
At -78 °C, 22.1 mL of n-butyllithium (35.4 mmol, 1.6 M hexane solution) was slowly added dropwise to a solution of 4.91 mL (35.0 mmol) of diisopropylamine in 45 mL of tetrahydrofuran, and the mixture was stirred at -78 °C for 10 minutes, followed by 25 minutes at 0 °C. Then, 5.00 g (34.7 mmol) of methyl tetrahydro-2H-pyran-4-carboxylate in a solution in 45 mL of tetrahydrofuran was added at -78 °C and the mixture continued to be stirred at -78 °C for 15 minutes. Next, 2.16 mL (34.7 mmol) of iodomethane was added dropwise at -78 °C and the reaction mixture was slowly warmed to -25 °C and stirred overnight at room temperature. Upon completion of the reaction, the reaction was terminated by the addition of 80 mL of 0.1 N hydrochloric acid and the organic and aqueous phases were separated. The aqueous phase was extracted twice with ethyl acetate, the organic phases were combined, dried with magnesium sulfate, filtered and concentrated under reduced pressure. The resulting suspension was ground with 20 mL of methyl tert-butyl ether, the precipitate was extracted, and the mother liquor was concentrated under reduced pressure to obtain methyl 4-methyl-tetrahydro-2H-pyran-4-carboxylate. Yield: 5.88 g (purity 95%, quantitative yield).1H NMR (400 MHz, DMSO-d6) δ (ppm): 3.70-3.64 (m, 2H), 3.64 (s, 3H), 3.37-3.30 (m, 2H), 1.94-1.88 (m, 2H), 1.45-1.37 (m, 2H), 1.16 (s 3H).
References
[1] Patent: US2016/52884, 2016, A1. Location in patent: Paragraph 1748-1750
[2] Patent: KR2015/137095, 2015, A. Location in patent: Paragraph 2557-2560
[3] Patent: US2018/148451, 2018, A1. Location in patent: Paragraph 0141; 0142; 0143
[4] Journal of Medicinal Chemistry, 2002, vol. 45, # 14, p. 2994 - 3008
[5] Patent: WO2005/58881, 2005, A1. Location in patent: Page/Page column 29-30
2H-Pyran-4-carboxylicacid,tetrahydro-4-methyl-,methylester(9CI) Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49936 | 58 |
| Sichuan Biosynce Pharmatech Co., Ltd. | +8619950309693 | diane@biosynce.com | China | 4871 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39002 | 58 |
