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SNS-032

SNS-032 Structure
SNS-032 structure
CAS No.
345627-80-7
Chemical Name:
SNS-032
Synonyms
CS-202;SNS-032;BMS-387032;BMS-3870032;SNS-032, >=99%;BMS-387032/SNS-032;SNS0032(BMS-387032);SNS-032, 98.5%, a selective CDK2 inhibitor;BMS-387032; SNS 032; SNS032; BMS 387032; BMS387032;1-diMethylethyl)-2-oxazolyl]Methyl]thio]-2-thiazolyl]-
CBNumber:
CB51518701
Molecular Formula:
C17H24N4O2S2
Molecular Weight:
380.53
MDL Number:
MFCD09833875
MOL File:
345627-80-7.mol
Last updated:2023-09-04 16:42:00
Request For Quotation

SNS-032 Properties

Melting point 171-173 °C
Density 1.28±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 7.33±0.70(Predicted)
color White to Off-White
EWG's Food Scores 1
FDA UNII 9979I93686

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  29349990

SNS-032 price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML2218 SNS-032 ≥98% (HPLC) 345627-80-7 5MG $56.52 2024-03-01 Buy
Sigma-Aldrich SML2218 SNS-032 ≥98% (HPLC) 345627-80-7 25MG $306 2024-03-01 Buy
Cayman Chemical 17904 SNS-032 ≥98% 345627-80-7 1mg $44 2024-03-01 Buy
Cayman Chemical 17904 SNS-032 ≥98% 345627-80-7 5mg $109 2024-03-01 Buy
Cayman Chemical 17904 SNS-032 ≥98% 345627-80-7 10mg $172 2024-03-01 Buy
Product number Packaging Price Buy
SML2218 5MG $56.52 Buy
SML2218 25MG $306 Buy
17904 1mg $44 Buy
17904 5mg $109 Buy
17904 10mg $172 Buy

SNS-032 Chemical Properties,Uses,Production

Description

Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. SNS-032 is an ATP-competitive inhibitor of Cdk9, 2, and 7 with IC50 values of 4, 38, and 62 nM, respectively. It is selective for these kinases and displays no additional activity against a panel of 190 kinases (IC50s = >1,000 nM). SNS-032 can block the cell cycle, inhibit transcription, and induce apoptosis in multiple myeloma RPMI-8226 cells with an IC90 value of 0.3 μM. This compound has been shown to induce apoptosis by inhibiting the transcription of the anti-apoptotic proteins, Mcl-1 and XIAP.

Chemical Properties

Off-White Solid

Uses

SNS 032 is a selective inhibitor of Cyclin-dependent Kinase (CDK) 2,7, and 9.

Definition

ChEBI: N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide is a secondary carboxamide resulting from the formal condensation of the carboxy group of piperidine-4-carboxylic acid with the amino group of 5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-amine. It is an ATP-competitive inhibitor of CDK2, CDK7 and CDK9 kinases and exhibits anti-cancer properties. It has a role as an apoptosis inducer, an antineoplastic agent, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor and an angiogenesis inhibitor. It is a piperidinecarboxamide, a member of 1,3-oxazoles, a member of 1,3-thiazoles, an organic sulfide and a secondary carboxamide.

storage

Store at -20°C

References

[1]. tong w.g., chen r., plunkett w., et al. phase i and pharmacologic study of sns-032, a potent and selective cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma. journal of clinical oncology, 2010, 28(18):3015- 3022.
[2]. chipumuro e., marco e., christensen c.l., et al. cdk7 inhibition suppresses super-enhancer-linked oncogenic transcription in mycn-driven cancer. cell, 2014, 159:1-14.
[3]. meng h., jin y.m., liu h., et al. sns-032 inhibits mtorc1/mtorc2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against akt. journal of hematology & oncology, 2013, 6:18.
[4]. chen r., wierda w.g., chubb s., et al. mechanism of action of sns032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia. blood, 2009, 113(19):4637-4645.

SNS-032 Preparation Products And Raw materials

Raw materials

Preparation Products

SNS-032 Suppliers

Global( 159)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 967 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23556 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29220 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
Biochempartner 		58
Chongqing Chemdad Co., Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
ANHUI WITOP BIOTECH CO., LTD 		58
Dideu Industries Group Limited 		58

View Lastest Price from SNS-032 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide pictures 2020-01-08 N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide
345627-80-7
 US $0.01 / KG 1KG 98%; 99% 1kg; 10kg; 25kg Career Henan Chemical Co

SNS-032 Spectrum

SNS-032(345627-80-7)1HNMR

345627-80-7(SNS-032)Related Search:

3,3-Dimethyl-1-butyne N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide hydrochloride N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea Y27632 (hydrochloride)
Alisertib (MLN8237) PD 0332991 HCl (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Flavopiridol (Alvocidib) HCl Olaparib
Hexahydroisonicotinamide 1-BOC-PIPERIDINE-4-CARBOXYLIC ACID [5-(5-TERT-BUTYL-OXAZOL-2-YLMETHYLSULFANYL)-THIAZOL-2-YL]-AMIDE SNS-032

1of3

BMS-3870032 N-[5-[(5-tert-Butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide N-[5-[(5-tert-Butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide SNS-032 (BMS-387032) N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamid SNS-032, >=99% N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide BMS-387032 4-Piperidinecarboxamide, N-(5-(((5-(1,1-dimethylethyl)-2-oxazolyl)methyl)thio)-2-thiazolyl)- N-(5-((5-Tert-Butyloxazol-2-yl)methylthio)thiazol-2-yl)piperidine-4-carboxamide 1-diMethylethyl)-2-oxazolyl]Methyl]thio]-2-thiazolyl]- N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide(BMS-3870032) BMS-3870032 SNS0032(BMS-387032) SNS-032 BMS-387032; SNS 032; SNS032; BMS 387032; BMS387032 CS-202 SNS 032; SNS032; SNS-032; BMS387032; BMS 387032; BMS-387032 SNS-032, 98.5%, a selective CDK2 inhibitor N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide USP/EP/BP N-[5-[(5-tert-Butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thia... BMS-387032/SNS-032 N-(5-(((4-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)piperidine-4-carboxamide 345627-80-7 C17H24N4O2S2 Inhibitors Specific and potent inhibitor of cyclin-dependent kinases (CDK) 2, 7 and 9. Aromatics Heterocycles Intermediates & Fine Chemicals. Sulfur & Selenium Compounds Pharmaceuticals Inhibitor of cyclin-dependent kinases (CDK) 2, 7 and 9.