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Acotiamide hydrochloride trihydrate

Acotiamide hydrochloride trihydrate
Acotiamide hydrochloride trihydrate structure
Chemical Name:
Acotiamide hydrochloride trihydrate
Ym-443;Acotiae;Acotiamide HCl;Unii-nmw7447A9a;Acofide trihydrate;Acotiamide trihydrate;Acotiamide HCl Hydrate;Acotiamide hydrochlorid;Acotiamide HCl Trihydrate;Acotiamide hydrochloride hydrate
Molecular Formula:
Formula Weight:
MOL File:

Acotiamide hydrochloride trihydrate Properties


Acotiamide hydrochloride trihydrate price

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Acotiamide hydrochloride trihydrate Chemical Properties,Uses,Production


In June 2013, the Ministry of Health, Labor and Welfare in Japan approved acotiamide (also referred to as Z-338 and YM443), for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia (FD). Acotiamide enhances acetylcholine release from enteric neurons through selective muscarinic acetylcholine receptor M1, M2 antagonism, and inhibition of AChE, thereby enhancing gastric emptying and gastric accommodation. Acotiamide inhibits the acetylcholine-induced Ca2+-activated Cl-current with an IC50 of 1.8 μM in oocytes expressing muscarinic M1 receptors and in oocytes expressing muscarinic M2 receptors, acotiamide inhibited the acetylcholine-induced K+ currents with an IC50 of 10.1 μM. However, studies in conscious dogs, guinea-pig gastric muscle strips and assays with human cholinesterase indicate that acotiamide inhibits AChE with a Ki of 610 nM suggesting that acotiamide stimulates gastric motility mainly by inhibiting AChE activation. In a restraint stress-induced rat model, acotiamide significantly improved delayed gastric emptying and feeding inhibition but did not affect normal gastric emptying or feeding in intact rats. A synthetic route to acotiamide that employs pyridine hydrochloride to selectively cleave a 2-substituted methyl ether from a 2,4,5-trimethoxy benzamide intermediate, as a key step, has been reported.


Zeria Pharmaceutical (Japan)

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Acotiamide hydrochloride trihydrate Preparation Products And Raw materials

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Acotiamide hydrochloride trihydrate Suppliers

Global( 112)Suppliers
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Anhui Dexinjia Biopharm Co., Ltd
86-531-82375893 CHINA 129 58
Shandong ruiyue Biological Technology Co.,Ltd.
008615066100122(Lily wechat);008618953188003(Fiona wechat);008618805314509(wechat)
053188581623;; CHINA 59 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21753 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20672 55
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 CHINA 24192 60
Lianyungang happen teng technology co., LTD
15950718863 CHINA 296 58
Hebei Chisure Biotechnology Co., Ltd.
0311 66567340 CHINA 1017 58
career henan chemical co
+86-371-86658258 CHINA 27142 58
Hebei Ruishun Trade Co.,LTD
17052563120 CHINA 302 58

View Lastest Price from Acotiamide hydrochloride trihydrate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-03 Acotiamide HCl hydrate
US $10.00 / KG 1KG 99.5% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2019-08-01 Acotiamide hydrochloride hydrate
US $1.00 / g 1g 99% 20000kg Cangzhou Wanyou New Material Technology Co.,Ltd
2018-08-01 Acotiamide hydrochloride trihydrate
US $2000.00 / KG 1KG 98% 10kg career henan chemical co

773092-05-0(Acotiamide hydrochloride trihydrate)Related Search:

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  • 773092-05-0
  • C21H30N4O5SHCl3H2O
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