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Demecarium bromide

Demecarium bromide
Demecarium bromide structure
CAS No.
56-94-0
Chemical Name:
Demecarium bromide
Synonyms
2br;bc48;e)(2:1);tonilen;humorsol;tosmicil;tosmilen;tosmilene;visumatic;Demecarium
CBNumber:
CB6501408
Molecular Formula:
C32H52Br2N4O4
Formula Weight:
716.59
MOL File:
56-94-0.mol

Demecarium bromide Properties

Melting point:
162-167 °C (decomp)
CAS DataBase Reference
56-94-0(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
HS Code  2924296000

Demecarium bromide Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Demecarium Bromide is an acetylcholinesterase inhibitor and veterinary medicine used to treat elevated intraocular pressure associated with primary glaucoma.

Uses

anticancer agent for pancreatic islet cells

Definition

ChEBI: The methobromide salt of the N,N'-bis[3-(dimethylamino)phenyl carbamate] derivative of 2,13-diazatetradecane. It is an inhibitor of acetylcholinesterase and pseudocholinesterase, with a long duration of action. It is u ed in the treatment of chronic open-angle glaucoma: in the eye, it causes constriction of the iris sphincter muscle and the ciliary muscle, facilitating the outflow of the aqueous humor and so reducing intraocular pressure.

brand name

Humorsol (Merck).

General Description

Demecarium bromide,(m-hydroxyphenyl)trimethylammonium bromide, decamethylenebis[methylcarbamate] (Humorsol), is the diester of(m-hydroxyphenyl)trimethylammonium bromide with decamethylene-bis-(methylcarbamic acid) and thus is comparableto a bis-prostigmine molecule.
It occurs as a slightly hygroscopic powder that is freelysoluble in water or alcohol. Ophthalmic solutions of the drughave a pH of 5 to 7.5. Aqueous solutions are stable and maybe sterilized by heat. Its efficacy and toxicity are comparableto those of other potent anticholinesterase inhibitor drugs. Itis a long-acting miotic used to treat wide-angle glaucomaand accommodative esotropia. Maximal effect occurs hoursafter administration, and the effect may persist for days.

Veterinary Drugs and Treatments

Demecarium is a potent carbamate inhibitor that may reduce intraocular pressures for up to 48 hours in canines. Demecarium reversibly inhibits anticholinesterase thereby causing miosis. Demecarium is generally used in preventive management of the contralateral eye in canine patients after the diagnosis of an acute congestive crisis of primary glaucoma in the other eye. It is not used in secondary glaucoma. Demecarium has the advantage of once or twice daily dosing.

Demecarium bromide Preparation Products And Raw materials

Raw materials

Preparation Products


Demecarium bromide Suppliers

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Mainchem Co., Ltd.
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