SB 203580 (hydrochloride)
- CAS No.
- 869185-85-3
- Chemical Name:
- SB 203580 (hydrochloride)
- Synonyms
- RWJ 64809 hydrochloride;Adezmapimod (hydrochloride);Adezmapimod (SB-203580) hydrochloride;SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem;RWJ 64809 HYDROCHLORIDE;SB203580 HYDROCHLORIDE;SB-203580 HYDROCHLORIDE
- CBNumber:
- CB52592405
- Molecular Formula:
- C21H17ClFN3OS
- Molecular Weight:
- 413.9
- MDL Number:
- MFCD01862622
- MOL File:
- 869185-85-3.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
HS Code | 2933399990 | |||||||||
NFPA 704 |
|
SB 203580 (hydrochloride) price More Price(20)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 559395 | SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kinase (IC = 34 nM in vitro, 600 nM in cells). |
869185-85-3 | 1mg | $172 | 2024-03-01 | Buy |
Sigma-Aldrich | 559395 | SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kinase (IC = 34 nM in vitro, 600 nM in cells). |
869185-85-3 | 10mg | $360 | 2024-03-01 | Buy |
Cayman Chemical | 13344 | SB 203580 (hydrochloride) ≥98% | 869185-85-3 | 5mg | $111 | 2024-03-01 | Buy |
Cayman Chemical | 13344 | SB 203580 (hydrochloride) ≥98% | 869185-85-3 | 10mg | $210 | 2024-03-01 | Buy |
Cayman Chemical | 13344 | SB 203580 (hydrochloride) ≥98% | 869185-85-3 | 25mg | $493 | 2024-03-01 | Buy |
SB 203580 (hydrochloride) Chemical Properties,Uses,Production
Uses
SB 203580 Hydrochloride is a protein kinase inhibitor.
General Description
A water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389).
Biological Activity
sb203580 hcl is a specific inhibitor of p38-mapks with ic50 value of 0.6 μm [1].sb203580 is an inhibitor of p38-mapkα and p38-mapkβ. in neonatal myocytes, sb203580 prevented p38-mapk from activating mapkapk2 with ic50 value of 70 nm. it also significantly suppressed mapkapk2 activation in by il-1, osmotic stress or arsenite in kb cells. in neonatal rat ventricular myocytes, sb203580 inhibited jnk activity of activating c-jun with ic50 value of 3-10 μm. besides that, sb203580 affected the phosphorylation of small heat shock proteins caused by mapkapk2. it inhibited the il-1-, chemical- or osmotic stress-stimulated hsp27 phosphorylation with ic50 value of < 1μm in kb cells [1, 2].
Biochem/physiol Actions
Cell permeable: yes
storage
Store at -20°C
References
[1] cuenda a, rouse j, doza y n, et al. sb 203580 is a specific inhibitor of a map kinase homologue which is stimulated by cellular stresses and interleukin-1. febs letters, 1995, 364(2): 229-233.
[2] clerk a, sugden p h. the p38-mapk inhibitor, sb203580, inhibits cardiac stress-activated protein kinases/c-jun n-terminal kinases (sapks/jnks). febs letters, 1998, 426(1): 93-96.
SB 203580 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
SB 203580 (hydrochloride) Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1494 | 55 | |
Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
---|---|
ATK CHEMICAL COMPANY LIMITED | 60 |
Career Henan Chemica Co | 58 |
InvivoChem | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | 58 |
LEAPCHEM CO., LTD. | 58 |
Aladdin Scientific | 58 |
Amadis Chemical Company Limited | 58 |
NCE Biomedical Co.,Ltd. | 55 |
Haoyuan Chemexpress Co., Ltd. | 61 |
Sigma-Aldrich | 80 |