Rosiptor
- CAS No.
- 782487-28-9
- Chemical Name:
- Rosiptor
- Synonyms
- AQX10;Rosiptor;semaglutide USP;semaglutide API;Rosiptor(AQX-1125);AQX 1125 (AQX-1125;semaglutide USP/EP/BP;Semaglutide-fermented;AQX-1125;AQX1125;ROSIPTOR;AQX1125,Rosiptor,Phosphatase,AQX 1125,Inhibitor,inhibit
- CBNumber:
- CB53044080
- Molecular Formula:
- C20H35NO2
- Molecular Weight:
- 321.5
- MDL Number:
- MFCD31619271
- MOL File:
- 782487-28-9.mol
| Boiling point | 451.6±45.0 °C(Predicted) |
|---|---|
| Density | 1.07±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 150 mg/mL (466.56 mM) |
| pka | 15.05±0.10(Predicted) |
| InChI | InChI=1S/C20H35NO2/c1-13-4-5-17-16(11-21)18(7-9-19(13,17)2)20(3)8-6-15(23)10-14(20)12-22/h14-18,22-23H,1,4-12,21H2,2-3H3/t14-,15+,16+,17+,18+,19-,20+/m1/s1 |
| InChIKey | MDEJTPWQNNMAQF-BVMLLJBZSA-N |
| SMILES | [C@H]1(CO)C[C@@H](O)CC[C@@]1([C@H]1CC[C@@]2(C)[C@]([H])([C@@H]1CN)CCC2=C)C |
| FDA UNII | 6R5034F862 |
Rosiptor price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0030509 | Rosiptor ≥98.0% | 782487-28-9 | 5mg | $700 | 2021-12-16 | Buy |
| ChemScene | CS-0030509 | Rosiptor ≥98.0% | 782487-28-9 | 10mg | $1100 | 2021-12-16 | Buy |
| ChemScene | CS-0030509 | Rosiptor ≥98.0% | 782487-28-9 | 50mg | $3500 | 2021-12-16 | Buy |
| ChemScene | CS-0030509 | Rosiptor ≥98.0% | 782487-28-9 | 100mg | $5500 | 2021-12-16 | Buy |
| DC Chemicals | DC23139 | AQX1125 >98% | 782487-28-9 | 1g | $2800 | 2021-12-16 | Buy |
Rosiptor Chemical Properties,Uses,Production
Description
Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. It inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro.
Uses
Rosiptor has been used in trials studying the treatment of COPD, Atopic Dermatitis, Interstitial Cystitis, and Bladder Pain Syndrome.
Biological Activity
Rosiptor is a small-molecule SHIP1 activator.The activating effect of Rosiptor on SHIP1 is 28% at 100 μM in the native enzyme but no effect of Rosiptor is observed when the SHIP1δC2 enzyme is used. Rosiptor induces a concentration-dependent decrease in Akt phosphorylation in MOLT-4 cells, while it fails to affect Akt phosphorylation in Jurkat cells. At 0.1 μM Rosiptor the inhibition amounts to an average of 34%, while at 10 μM the inhibition amounts to an average of 82% in two independent experiments. Rosiptor also induces a concentration-dependent decrease in the production of multiple pro-inflammatory mediators in this system, without affecting cell viability. Rosiptor dose dependently inhibits chemotaxis of most cell types at low micromolar concentrations independent of the chemotactic stimulus.
Rosiptor Preparation Products And Raw materials
Raw materials
Preparation Products
Rosiptor Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Apextide Co Ltd | +undefined15700198315 | senjie.hou@sinopep.com | China | 71 | 58 |
| qingdao future trading Co., Ltd | +86-13335044410 +86-13335044410 | cui56813@163.com | China | 110 | 58 |
| Shandong Huisheng Import & Export Co., Ltd. | +86-13176845580 +86-13176845580 | da@zhongda-biotech.com | China | 248 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 | justine@zhongda-biotech.com | China | 300 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8615689548120 | linda@zhongda-biotech.com | China | 204 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Shochem(Shanghai) Co.,Ltd | 86-21-50800795 | info@shochem.com | CHINA | 288 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81148696 +8615536356810 | 1047@dideu.com | China | 3408 | 58 |
View Lastest Price from Rosiptor manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-27 | semaglutide USP；EP；BP
782487-28-9
|
US $25.00-20.00 / g | 1g | 99% | 100kg | Wuhan Cell Pharmaceutical Co., Ltd | |
 |
2023-11-09 | semaglutide
782487-28-9
|
US $1600.00 / gram | 1gram | 99.99% | 10kg | qingdao future trading Co., Ltd | |
 |
2023-11-03 | Rosiptor
782487-28-9
|
US $0.00-0.00 / g | 1g | 99% | 100000tons | Anhui Zhongda Biotechnology Co., Ltd |
-
- semaglutide USP；EP；BP
782487-28-9
- US $25.00-20.00 / g
- 99%
- Wuhan Cell Pharmaceutical Co., Ltd
-
- semaglutide
782487-28-9
- US $1600.00 / gram
- 99.99%
- qingdao future trading Co., Ltd
-
- Rosiptor
782487-28-9
- US $0.00-0.00 / g
- 99%
- Anhui Zhongda Biotechnology Co., Ltd