LDC4297
- CAS No.
- 1453834-21-3
- Chemical Name:
- LDC4297
- Synonyms
- LDC4297;CS-2540;CS-2539;LDC044297;LDC4297;LDC 4297;LDC4297(LDC044297);N-(2-(1H-Pyrazol-1-yl)benzyl)-8-isopropyl-2-(piperidin-3-yloxy)pyrazolo[1,5-a][1,3,5]triazin-4-amine;Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-(1-methylethyl)-2-(3-piperidinyloxy)-N-[[2-(1H-pyrazol-1-yl)phenyl]methyl]-
- CBNumber:
- CB53171481
- Molecular Formula:
- C23H28N8O
- Molecular Weight:
- 432.52
- MDL Number:
- MFCD28411427
- MOL File:
- 1453834-21-3.mol
LDC4297 price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23398 | LDC-4297 ≥98% | 1453834-21-3 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 23398 | LDC-4297 ≥98% | 1453834-21-3 | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 23398 | LDC-4297 ≥98% | 1453834-21-3 | 10mg | $283 | 2024-03-01 | Buy |
| Cayman Chemical | 23398 | LDC-4297 ≥98% | 1453834-21-3 | 25mg | $573 | 2024-03-01 | Buy |
| TRC | L367665 | LDC4297 | 1453834-21-3 | 25mg | $3795 | 2021-12-16 | Buy |
LDC4297 Chemical Properties,Uses,Production
Description
LDC-4297 is an inhibitor of cyclin-dependent kinase 7 (CDK7; IC50 = <5 nM). It is selective for CDK7 over CDK4, CDK6, and CDK9 (IC50s = >10, >10, and 1.71 μM), however, it also inhibits CDK2 and CDK1 (IC50s = 6.4 and 53.7 nM, respectively). LDC-4297 (10-100 nM) induces apoptosis in A549, HeLa, and HCT116 cancer cells in a concentration-dependent manner. It inhibits human cytomegalovirus (HCMV) replication in human fibroblasts (EC50 = 24.5 nM). LDC-4297 also reduces replication of Herpesviridae, Adenoviridae, Poxviridae, Retroviridae, and Orthomyxoviridae family viruses (EC50s = 0.02-1.13 μM).
Uses
Cyclin-dependent protein kinase 7 (CDK7) is involved with a broad range of regulatory roles in cell cycle and transcription, which is essential for viral replication. LDC 4297 is a CDK7 inhibitor that can be used to develop antiviral drugs.
Definition
ChEBI: LDC4297 is a pyrazolotriazine that is pyrazolo[1,5-a][1,3,5]triazine substituted by a piperidin-3-yloxy group, [2-(1H-pyrazol-1-yl)benzyl]nitrilo group and an isopropyl group at positions 2, 4 and 8 respectively. It is a potent and selective CDK7 inhibitor and exhibits antiviral activity. It has a role as an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an apoptosis inducer, an antineoplastic agent and an antiviral agent. It is a pyrazolotriazine, a member of pyrazoles, a member of piperidines, a secondary amino compound and an aromatic ether.
LDC4297 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |