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Naringenin

Pharmacological effects Application
Naringenin
Naringenin structure
CAS No.
480-41-1
Chemical Name:
Naringenin
Synonyms
ringenin;NSC 11855;NSC 34875;salipurol;NARIGENIN;naringetol;salipurpol;NARINGENIN;naringenine;pelargidanon
CBNumber:
CB5325311
Molecular Formula:
C15H12O5
Formula Weight:
272.25
MOL File:
480-41-1.mol

Naringenin Properties

Melting point:
247-250 °C(lit.)
Boiling point:
335.31°C (rough estimate)
Density 
1.2066 (rough estimate)
refractive index 
1.6000 (estimate)
FEMA 
4797 | (+/-)-NARINGENIN
storage temp. 
Inert atmosphere,Room Temperature
form 
Powder
pka
7.52±0.40(Predicted)
color 
Beige-brown
CAS DataBase Reference
480-41-1(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
HN5425SBF2
EPA Substance Registry System
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-, (2S)- (480-41-1)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22
Safety Statements  26-36-37/39
WGK Germany  3
HazardClass  IRRITANT
HS Code  29329990

Naringenin price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W530098 Naringenin natural (US), 98% 480-41-1 SAMPLE $50 2021-03-22 Buy
Sigma-Aldrich W530098 Naringenin natural (US), 98% 480-41-1 500 g $571 2021-03-22 Buy

Naringenin Chemical Properties,Uses,Production

Pharmacological effects

Naringenin is the aglycone of naringin, it belongs to dihydro-flavonoids, at room temperature it is a white needle crystal(methanol), soluble in alcohol, ether and benzene, almost insoluble in water. In HCl-Mg powder reaction,it is cherry red ,in sodium borohydride reaction it is red purple, in molish reaction,it is negative. In the nature, it is mainly from the Rosaceae cherry (Prunus yedoensis Mate.) bud,and sumac plants (Amacardi-um occidentale L.)  fruits’ core-shell.
Nucleus structure is similar among flavonoids, most of the components do not have ideal fat-soluble and water-soluble abilities, the bioavailability is low. By modifying its structure, the introduction of strongly fat-soluble or water-soluble groups can increase its fat-soluble or water-soluble abilities, thus improving the bioavailability. The structure modification includes alkylation, acylation, sulfonation,glycosidation  of hydroxyl groups and the formation of the metal complex.
The effects of naringenin including: anti-bacterial, anti-inflammatory, antioxidant, cough expectorant,decreasing blood fat, anti-cancer and anti-tumor, antispasmodic, scavenging free radicals, prevention and treatment of liver disease, inhibition of platelet aggregation, anti-atherosclerosis and others , which can be widely used in medicine, food and other fields.
1. Antibacterial: it has a strong antibacterial effect on Staphylococcus aureus, Escherichia coli, Shigella dysenteriae, and Salmonella typhi. Naringenin also has effect on fungi  , 1000ppm is sprayed onto the rice, blast fungus infection can be reduced 40-90%,and it is not toxic to livestock and humans.
2. Anti-inflammatory: intraperitoneal injection of 20mg/kg per day for rats can inhibit the inflammatory process which caused by wool ball implantation.
3. Anticancer:  it displays action in L1210 leukemia and sarcomas in rats.
4. Antispasmodic and gallbladder: among the flavonoids,it has stronger effects. Naringenin has a strong effect on increasing bile secretion in experimental animals.

Application

It has anti-bacterial, anti-inflammatory, anti-cancer, antispasmodic and choleretic effects.

Chemical Properties

beige-brown powder

Uses

The aglucon of Naringin. Inhibitory mechanism of Naringenin against carcinogenic acrylamide formation and nonenzymic browning in Maillard model reactions

Uses

antiulcer, antioxidant, immunomodulator, cholesterol lowering

Purification Methods

Crystallise it from EtOH or aqueous EtOH. It has UV: at 290nm (EtOH). The S(-)-enantiomer (natural form) has m 255-256o (from EtOH) and [] D -28.0o (c 2, EtOH), [] D -35.2o (c 1, pyridine).

Naringenin Preparation Products And Raw materials

Raw materials

Preparation Products


Naringenin Suppliers

Global( 361)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
NanJing Spring & Autumn Biological Engineering CO., LTD.
0086 13815430202 0086 13815430202
sale02@cqherb.com CHINA 372 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21032 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58

View Lastest Price from Naringenin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-26 (s)-Naringenin 480-41-1
480-41-1
US $20.00 / g 1g ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2021-08-26 Naringenin
480-41-1
US $8.70 / Kg/Bag 10g 98.0% min 10000kg Hebei Crovell Biotech Co Ltd
2021-07-22 Naringenin
480-41-1
US $255.00 / KG 1KG 98% 10000KG Baoji Guokang Bio-Technology Co., Ltd.

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