tert-Butyl 4-aminobenzoate
- CAS No.
- 18144-47-3
- Chemical Name:
- tert-Butyl 4-aminobenzoate
- Synonyms
- BUTTPARK 14\02-67;tert-Butyl 4-aminobe;ert-butyl4-aminobenzoate;Tert-Butyl p-aMinobenzoate;TERT-BUTYL 4-AMINOBENZOATE;tert-butyl 4-azanylbenzoate;4-(tert-Butoxycarbonyl)aniline;tert-Butyl 4-Aminobenzoate >1,1-Dimethylethyl 4-aminobenzoate;4-AMINOBENZOIC ACID TERT-BUTYL ESTER
- CBNumber:
- CB5329814
- Molecular Formula:
- C11H15NO2
- Molecular Weight:
- 193.24
- MDL Number:
- MFCD00665790
- MOL File:
- 18144-47-3.mol
- MSDS File:
- SDS
| Melting point | 108-110 °C |
|---|---|
| Boiling point | 322.4±15.0 °C(Predicted) |
| Density | 1.078±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | powder to crystal |
| pka | 2.43±0.10(Predicted) |
| color | White to Light yellow to Light orange |
| BRN | 2803178 |
| CAS DataBase Reference | 18144-47-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-34 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29224999 | |||||||||
| NFPA 704 |
|
tert-Butyl 4-aminobenzoate price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 06975 | tert-Butyl 4-aminobenzoate ≥98.0% (NT) | 18144-47-3 | 5g | $97.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | 06975 | tert-Butyl 4-aminobenzoate ≥98.0% (NT) | 18144-47-3 | 25g | $375 | 2024-03-01 | Buy |
| TCI Chemical | B3504 | tert-Butyl 4-Aminobenzoate >98.0%(GC)(T) | 18144-47-3 | 5g | $80 | 2024-03-01 | Buy |
| TCI Chemical | B3504 | tert-Butyl 4-Aminobenzoate >98.0%(GC)(T) | 18144-47-3 | 25g | $228 | 2024-03-01 | Buy |
| TRC | B809723 | tert-Butyl 4-Aminobenzoate | 18144-47-3 | 50mg | $45 | 2021-12-16 | Buy |
tert-Butyl 4-aminobenzoate Chemical Properties,Uses,Production
Uses
tert-Butyl 4-aminobenzoate can be used to synthesise structural units for antifolate and a novel liver-targeted coupling of PSN-357, a glycogen phosphorylase inhibitor for the treatment of diabetes. It can also be used in the synthesis of tert-butyl 4-aminobenzoate n-substituted derivatives[1].
Synthesis
tert-Butyl 4-aminobenzoate is synthesised using tert-butyl 4-nitrobenzoate as raw material by chemical reaction. The specific synthesis steps are as follows:
Tert-butyl 4-nitrobenzoate (4.75 g, 21.279 mmol) was dissolved in MeOH (200 ml) and added with CAUTION was Pd/C (475 mg, 0.1 equiv. w/w) and the flask evacuated prior to purging with N2, re-evacuation and purging with H2. The mixture was stirred under H2 for 5 hours until complete. The mixture was filtered through celite and evaporated to a white solid (4.11 g, 21.269 mmol, quant.). Rf 0.29 [20% EtOAc in Hexane]. Mp. I l l - 113 0C. 1H NMR (400 MHz, CDCl3) δ 7.79 (2H, dt, J=8.6, 2.3 Hz, 2ArH), 6.61 (2H, dt, J=8.6, 2.3 Hz, 2ArH), 4.00 (2H, br s, NH2), 1.56 (9H, s, C(CH3)3) ppm. 13C NMR (100 MHz, CDCl3) δ 165.9 (C=O), 150.4 (ArC), 131.3 (ArCH), 121.7 (ArC), 113.7 (ArCH), 80.0 (C(CH3)3), 28.3 (C(CH3)3) ppm. IR (neat) υmax 3415, 3345, 3235, 2972, 1682, 1598, 1367, 1287, 1154, 1115 cm 1. HRMS mJz calc. C11H15NO2 [M+l] 194.1176, found [M+l] 194.1179.
References
[1] V. BAVETSIAS E. H. Synthesis of N-substituted derivatives of tert-butyl 4-aminobenzoate via a palladium-catalysed reaction[J]. Journal of Chemical Research-s, 2000. DOI:10.3184/030823400103168100.
tert-Butyl 4-aminobenzoate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 951 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2169 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
View Lastest Price from tert-Butyl 4-aminobenzoate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-26 | Tert-Butyl 4-aminobenzoate
18144-47-3
|
US $10.00 / kg | 1kg | 98% | 1000kg | hebei hongtan Biotechnology Co., Ltd | |
 |
2023-05-16 | tert-Butyl 4-aminobenzoate
18144-47-3
|
US $0.00 / kg | 1kg | 99% | 500kgs | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2023-02-18 | Tert-Butyl4-aminobenzoate
18144-47-3
|
US $0.00-0.00 / kg | 1kg | 98% | kgs | Aromsyn Co., Ltd. |
-
- Tert-Butyl 4-aminobenzoate
18144-47-3
- US $10.00 / kg
- 98%
- hebei hongtan Biotechnology Co., Ltd
-
- tert-Butyl 4-aminobenzoate
18144-47-3
- US $0.00 / kg
- 99%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Tert-Butyl4-aminobenzoate
18144-47-3
- US $0.00-0.00 / kg
- 98%
- Aromsyn Co., Ltd.