2,3,4,6-Tetrafluoronitrobenzene
- CAS No.
- 314-41-0
- Chemical Name:
- 2,3,4,6-Tetrafluoronitrobenzene
- Synonyms
- 1,2,3,5-Tetrafluoro-4-nitrobenzene;2,3,4,6-TetrafL;2,3,4,6-TETRAFLUORON;5-fluro-2-methylaniline;5-tetrafluoro-4-nitrobenzene;1,2,4,6-Tetrafluoronitrobenzene;2,3,4,6-Tetrafluoronitrobenzene;2-Nitro-1,3,4,5-tetrafluorobenzene;1-Nitro-2,3,4,6-tetrafluorobenzene;2,3,4,6-Tetrafluoronitrobenzene98%
- CBNumber:
- CB5351352
- Molecular Formula:
- C6HF4NO2
- Molecular Weight:
- 195.07
- MDL Number:
- MFCD00011687
- MOL File:
- 314-41-0.mol
- MSDS File:
- SDS
| Melting point | -5 |
|---|---|
| Boiling point | 78-79°C 20mm |
| Density | 1.511 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 160 °F |
| storage temp. | 2-8°C |
| form | liquid |
| Specific Gravity | 1.511 |
| Appearance | Colorless to light yellow Liquid |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases. Combustible. |
| InChI | 1S/C6HF4NO2/c7-2-1-3(8)6(11(12)13)5(10)4(2)9/h1H |
| InChIKey | FDLCUAUNAWWSBX-UHFFFAOYSA-N |
| SMILES | [O-][N+](=O)c1c(F)cc(F)c(F)c1F |
| CAS DataBase Reference | 314-41-0(CAS DataBase Reference) |
| FDA UNII | SU82FD6B27 |
| EPA Substance Registry System | Benzene, 1,2,3,5-tetrafluoro-4-nitro- (314-41-0) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 2904990090 |
| Storage Class | 10 - Combustible liquids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
2,3,4,6-Tetrafluoronitrobenzene price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FT97972 | 2,3,4,6-Tetrafluoronitrobenzene | 314-41-0 | 10g | $584.1 | 2026-06-04 | Buy |
| Biosynth | FT97972 | 2,3,4,6-Tetrafluoronitrobenzene | 314-41-0 | 25g | $778.75 | 2026-06-04 | Buy |
| Biosynth | FT97972 | 2,3,4,6-Tetrafluoronitrobenzene | 314-41-0 | 50g | $1038.5 | 2026-06-04 | Buy |
| Biosynth | FT97972 | 2,3,4,6-Tetrafluoronitrobenzene | 314-41-0 | 100g | $1622 | 2026-06-04 | Buy |
| Apolloscientific | PC6810 | 2,3,4,6-Tetrafluoronitrobenzene 97% | 314-41-0 | 250mg | $48 | 2026-06-04 | Buy |
2,3,4,6-Tetrafluoronitrobenzene Chemical Properties, Uses, Production
Chemical Properties
yellow liquid
Uses
Molluscicidal activity of 2,3,4,6-tetrafluoronitrobenzene against Biomphalaria glabrata has been investigated. Palladium-catalyzed cross-coupling reactions of 2,3,4,6-tetrafluoronitrobenzene with alkyne derivatives has been studied. Reaction of 2,3,4,6-tetrafluoronitrobenzene with 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene in the presence of water molecules in acetonitrile has been investigated.
General Description
Molluscicidal activity of 2,3,4,6-tetrafluoronitrobenzene against Biomphalaria glabrata has been investigated. Palladium-catalyzed cross-coupling reactions of 2,3,4,6-tetrafluoronitrobenzene with alkyne derivatives has been studied. Reaction of 2,3,4,6-tetrafluoronitrobenzene with 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene in the presence of water molecules in acetonitrile has been investigated.
Synthesis
2367-82-0
314-41-0
For the large-scale synthesis of 1,2,3,5-tetrafluoro-4-nitrobenzene, a mixed solution of concentrated nitric acid (990 g) in concentrated sulfuric acid (973 mL) was first pre-cooled, and then the mixed solution was slowly added to a cold solution of 1,2,3,5-tetrafluorobenzene (973.1 g) dissolved in concentrated sulfuric acid (2,920 mL) at temperatures ranging from 0 °C to 10 °C, with the addition process being controlled to be completed within 1.5 The addition process was completed within 1.5 hours. After the addition was completed, the reaction temperature was maintained between 0 °C and 10 °C, and the yellow reaction solution was continued to be stirred for 1 hour until the analysis confirmed the completion of the reaction. Subsequently, the reaction solution was slowly poured into water (9730 g) that had been pre-cooled to below 25 °C, and dichloromethane (9730 mL) was added for extraction. After separation of the organic phase, it was washed twice with deionized water (10 L). The dichloromethane layer was concentrated to give a yellow oil. Finally, the oily substance was distilled under reduced pressure (2.5 mbar) at 70 °C to 75 °C to give a yellow oily product with 98% purity and 72.4% yield.
References
[1] Journal of Organic Chemistry, 1995, vol. 60, # 22, p. 7348 - 7350
[2] Patent: US2012/316149, 2012, A1. Location in patent: Page/Page column 11
[3] Patent: WO2012/168884, 2012, A1. Location in patent: Page/Page column 26; 27
[4] Russian Chemical Bulletin, 1998, vol. 47, # 5, p. 924 - 927
[5] Journal of the American Chemical Society, 1951, vol. 73, p. 153
2,3,4,6-Tetrafluoronitrobenzene Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9656 | 58 |
| Huainan Kedi Chemical Factory | 0554-2106669 | sales1@kedichem.com | China | 4914 | 55 |
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