ChemicalBook >> CAS DataBase List >>PHENYRAMIDOL

PHENYRAMIDOL

CAS No.
553-69-5
Chemical Name:
PHENYRAMIDOL
Synonyms
Cabral;IN 511;Miodar;MJ 505;Bonapar;Vilexin;Analexin;Evasprin;Abbolexin;Evasprine
CBNumber:
CB5408779
Molecular Formula:
C13H14N2O
Molecular Weight:
214.26
MDL Number:
MFCD00242756
MOL File:
553-69-5.mol
MSDS File:
SDS
Last updated:2023-05-04 17:34:39

PHENYRAMIDOL Properties

Melting point 82-85°
Boiling point 354.4°C (rough estimate)
Density 1.0850 (rough estimate)
refractive index 1.6450 (estimate)
pka 5.85(at 25℃)
FDA UNII R3V02WL7O3
ATC code M03BX30
EPA Substance Registry System Fenyramidol (553-69-5)

SAFETY

Risk and Safety Statements

Toxicity LD50 oral in rat: 756mg/kg

PHENYRAMIDOL price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC P338350 (±)-Phenyramidol 553-69-5 100mg $1320 2021-12-16 Buy
American Custom Chemicals Corporation CHM1051764 1-PHENYL-2-(PYRIDIN-2-YLAMINO)ETHANOL 95.00% 553-69-5 5MG $453.89 2021-12-16 Buy
Product number Packaging Price Buy
P338350 100mg $1320 Buy
CHM1051764 5MG $453.89 Buy

PHENYRAMIDOL Chemical Properties,Uses,Production

Originator

Analexin, Mallinckrodt Inc., US ,1960

Uses

Analgesic; relaxant (skeletal muscle).

Uses

(±)-Phenyramidol can be used in biological study of preparation of nitric oxide releasing prodrugs useful in the treatment of diseases. It is also a muscle relaxant drug.

Definition

ChEBI: Fenyramidol is an aminopyridine.

Manufacturing Process

A mixture containing 188 g (0.20 mol) of 2-arninopyridine, 0.55 g of lithium amide and 75 cc of anhydrous toluene was refluxed for 1.5 hours. Styrene oxide (12.0 g = 0.10 mol) was then added to the reaction mixture with stirring over a period of ten minutes. The reaction mixture was stirred and refluxed for an additional 3.5 hours. A crystalline precipitate was formed during the reaction which was removed by filtration, MP 170°C to 171°C. 1.5 g. The filtrate was concentrated to dryness and a dark residue remained which was crystallized from anhydrous ether; yield 6.0 g. Upon recrystallization of the crude solid from 30 cc of isopropyl alcohol, 2.0 g of a light yellow solid was isolated; MP 170° to 171°C.

Therapeutic Function

Analgesic, Muscle relaxant

Synthesis Reference(s)

Journal of the American Chemical Society, 81, p. 4351, 1959 DOI: 10.1021/ja01525a062

General Description

Crystals (from dilute methanol).

Reactivity Profile

PHENYRAMIDOL is an amine and an alcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Fire Hazard

Flash point data for PHENYRAMIDOL are not available. PHENYRAMIDOL is probably combustible.

PHENYRAMIDOL Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32836 60
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569266 15319487004 1015@dideu.com China 4088 58
Shaanxi Dideu Medichem Co. Ltd 029-61856359 19815193980 1018@dideu.com China 10011 58
guoyungurui 18162595016 3287908757@qq.com China 10338 58

553-69-5(PHENYRAMIDOL)Related Search:

1-Phenyl-2-(2-pyridinylamino)ethanol 2-(beta-Hydroxyphenethylamino)Pyridine α-[(2-Pyridylamino)methyl]benzyl alcohol 1-phenyl-2-(2-pyridylamino)ethanol 1-phenyl-2-(pyridin-2-ylamino)ethanol Abbolexin alpha-[(2-Pyridylamino)methyl]benzyl alcohol Analexin Benzenemethanol, alpha-[(2-pyridinylamino)methyl]- Benzyl alcohol, alpha-[(2-pyridylamino)methyl]- Bonapar Cabral Evaspirine Evasprin Evasprine Fenyramidol Fenyripol IN 511 Miodar MJ 505 Phenylramidol Vilexin PHENYRAMIDOL Benzenemethanol, α-[(2-pyridinylamino)methyl]- Fenyramidol D4 553-69-5