ChemicalBook >> CAS DataBase List >>ZT-12-037-01
ZT-12-037-01
- CAS No.
- 2328073-61-4
- Chemical Name:
- ZT-12-037-01
- Synonyms
- ZT-12-037-01;inhibit,ZT 12 037 01,ZT1203701,Ras,Inhibitor;N2-Cyclopropyl-N4-(1-isopropylpiperidin-4-yl)-6,7-dimethoxyquinazoline-2,4-diamine;2,4-Quinazolinediamine, N2-cyclopropyl-6,7-dimethoxy-N4-[1-(1-methylethyl)-4-piperidinyl]-
- CBNumber:
- CB54927142
- Molecular Formula:
- C21H31N5O2
- Molecular Weight:
- 385.5
- MDL Number:
- MFCD32197197
- MOL File:
- 2328073-61-4.mol
Last updated:2023-09-20 16:43:00
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
ZT-12-037-01 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0090099 | ZT-12-037-01 98.21% | 2328073-61-4 | 5mg | $80 | 2021-12-16 | Buy |
| ChemScene | CS-0090099 | ZT-12-037-01 98.21% | 2328073-61-4 | 10mg | $140 | 2021-12-16 | Buy |
| Axon Medchem | Axon2937 | ZT-12-037-01 99% | 2328073-61-4 | 25mg | $335.5 | 2021-12-16 | Buy |
| ChemScene | CS-0090099 | ZT-12-037-01 98.21% | 2328073-61-4 | 50mg | $560 | 2021-12-16 | Buy |
| ChemScene | CS-0090099 | ZT-12-037-01 98.21% | 2328073-61-4 | 100mg | $980 | 2021-12-16 | Buy |
ZT-12-037-01 Chemical Properties,Uses,Production
Biological Activity
ZT-12-037-01 is an ATP-competitive STK19 inhibitor with IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. At a concentration of 1 μM, it is highly selective against a kinase library of 468 kinases.
in vitro
Treatment with ZT-12-037-01 could effectively inhibit NRAS phosphorylation. ZT-12-037-01 is an ATP-competitive inhibitor that potently inhibits melanocytic colony formation, proliferation and tumor formation driven by mutant NRAS-STK19. It's pro-apoptotic activity was significantly enhanced in cells expressing oncogenic NRAS.
in vivo
ZT-12-037-01 is a potent STK19 inhibitor with low toxicity in vivo. In the SK-MEL-2 xenograft model (carrying NRAS.
target
| Target | Value | ||||
| STK19 (Cell-free assay) | 23.96 nM | ||||
| STK19 (D89N) (Cell-free assay) | 27.94 nM |
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 991 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2981 | 58 |
2328073-61-4(ZT-12-037-01)Related Search:
ZT-12-037-01
2,4-Quinazolinediamine, N2-cyclopropyl-6,7-dimethoxy-N4-[1-(1-methylethyl)-4-piperidinyl]-
inhibit,ZT 12 037 01,ZT1203701,Ras,Inhibitor
N2-Cyclopropyl-N4-(1-isopropylpiperidin-4-yl)-6,7-dimethoxyquinazoline-2,4-diamine
2328073-61-4