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JC-1

JC-1 structure

CAS No.: 3520-43-2

Chemical Name:: JC-1

Synonyms: JC-1;JC-1, >95%;JC-1 jodide;CBIC2, >95%;ChemicalbookCBIC2,>95%;JC-1[5,5,6,6-Tetrachloro-1,1,3,3;-tetrachloroimidacarbocyanine iodide;inhibit,CBIC-2,JC1,CBIC 2,JC 1,JC-1,Inhibitor;5,5',6,6'-TETRACHLORO-1,1',3,3'-*TETRAETHYBENZIMIDA;1,10,3,30-tetraethyl-5,50,6,60-tetrachloroimidacarbocyanine Iodide

CBNumber:: CB5497188

Molecular Formula:: C25H27Cl4N4.I

Molecular Weight:: 652.228

MDL Number:: MFCD00188475

MOL File:: 3520-43-2.mol

Last updated:2023-06-08 09:02:15

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JC-1 Properties

Melting point	275–278 ℃
storage temp.	room temp
solubility	Soluble in methanol, N,N-dimethyl formamide, dimethyl sulfoxide
form	crystals
color	Deep red
λmax	514nm
Stability	Store as supplied desiccated at -20°C for up to 2 years from the date of purchase. Solutions in DMSO or distilled water may be stored at 4°C for up to 1 year. DO NOT FREEZE/THAW SOLUTIONS. Sterilize solutions only by filtration, not by autoclaving
Biological Applications	Detectingmitochondrialmembrane potential,ABCB1,ABCC1,and ABCG2 transporters inhibitors,nucleic acid hybridization,prostate cancer; treating cellular death,Alzheimer’s disease; apoptosis assay; cytotoxicity assay; hematotoxicity
Major Application	Langmuir-Blodgett films; lasing systems; nonlinear optical materials; photographic materials1,
InChIKey	FYNNIUVBDKICAX-UHFFFAOYSA-M

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS09

Signal word

Warning

Hazard statements

H315-H410-H335-H319-H302

Precautionary statements

P273-P391-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P

WGK Germany

10-21

NFPA 704

	0
2		0

JC-1 price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T4069	JC-1 solid	3520-43-2	5mg	$632	2024-03-01	Buy
Cayman Chemical	15003	JC-1 ≥90%	3520-43-2	1mg	$68	2024-03-01	Buy
Cayman Chemical	15003	JC-1 ≥90%	3520-43-2	5mg	$302	2024-03-01	Buy
Cayman Chemical	15003	JC-1 ≥90%	3520-43-2	10mg	$535	2024-03-01	Buy
TRC	J211955	JC-1iodide	3520-43-2	2.5mg	$275	2021-12-16	Buy

Product number	Packaging	Price	Buy
T4069	5mg	$632	Buy
15003	1mg	$68	Buy
15003	5mg	$302	Buy
15003	10mg	$535	Buy
J211955	2.5mg	$275	Buy

JC-1 Chemical Properties,Uses,Production

Description

JC-1 is a membrane-permeable cationic dye that is used to study mitochondrial integrity in the context of cellular apoptosis. It selectively enters mitochondria and changes fluorescence characteristics with alteration in mitochondrial transmembrane potential (ΔΨm). In healthy cells with a high mitochondrial ΔΨm, JC-1 forms complexes known as J-aggregates, which fluoresce red/orange and may be detected using FL2 settings by flow cytometry. A drop in ΔΨm, a very early event in apoptosis, results in JC-1 monomers, which fluoresce green (FL1 settings on flow cytometers). JC-1 may also be used with fluorescent microscopes or plate readers, using excitation at 520-570 nm and emission at 570-610 nm for J-aggregates and excitation at 485 nm and emission at 535 nm for monomers.

Uses

A dual-emission potential-sensitive probe that can be used to measure mitochondrial membrane potential. JC-1 is a green-fluorescent monomer at low membrane potential. At higher potentials, JC-1 forms red-fluorescent "J-aggregates," which exhibit broad exc

Uses

The cyanine dye JC-1 has been used to determine mitochondrial transmembrane potential.

Definition

ChEBI: 1,1',3,3'-tetraethyl-5,5',6,6'-tetrachloroimidacarbocyanine iodide is a cyanine dye and an organic iodide salt. It has a role as a fluorochrome. It contains a 1,1',3,3'-tetraethyl-5,5',6,6'-tetrachloroimidacarbocyanine.

References

1) Reers et al. (1991), J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential; Biochemistry, 30 4480 2) Smiley et al. (1991), Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1; Proc. Natl. Acad. Sci. USA, 88 3671 3) Lisa et al. (1995), Mitochondrial membrane potential in single living adult rat cardiac myocytes exposed to anoxia or metabolic inhibition; J. Physiol., 486 1 4) Wolosin et al. (2017), Application of JC1 for non-toxic isolation of cells with MDR transporter activity by flow cytometry; PLoS One, 12(4) e0174905 5) Wang et al. (2017), A novel cytoprotective peptide protects mesenchymal stem cells against mitochondrial dysfunction and apoptosis induced by starvation via Nrf2/Sirt3/FoxO3a pathway; J. Transl. Med., 15 33

JC-1 Preparation Products And Raw materials

Raw materials

Preparation Products

JC-1 Suppliers

Global( 92)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Jiangxi Lotchem Co.,Ltd.	+8615270827708	lancetu@jxlotchem.com	CHINA	338	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42057	58

Supplier	Advantage
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Jiangxi Lotchem Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Zhejiang J&C Biological Technology Co.,Limited	58
Alfa Chemistry	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Jilin Chinese Academy of Sciences-yanshen Technology	58

View Lastest Price from JC-1 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-05	JC-1 3520-43-2	US $1.00 / KG	1KG	95--99%	1ton	Career Henan Chemical Co

JC-1
3520-43-2
US $1.00 / KG
95--99%
Career Henan Chemical Co

JC-1 Spectrum

JC-1(3520-43-2)¹HNMR

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JC-1 CHLORIDE 1,3-DIMETHYLIMIDAZOLIUM IODIDE 5,6-DICHLORO-2-METHYLBENZIMIDAZOLE 5,6-Dichloro-1-ethyl-2-methylbenzimidazole JC-1

1-ETHYL-3-METHYLIMIDAZOLIUM IODIDE 5,6-DICHLOROBENZIMIDAZOLE 5-CHLORO-1,2-DIMETHYLBENZIMIDAZOLE 1H-Benzimidazole,2-ethenyl-(9CI) N-ETHYL-5,6-DICHLOROBENZIMIDAZOLE

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5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine iodide JC-1 JC-1,5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethyl-imidacarbocyanine iodide, 5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolocarbocyanine iodide, CBIC2(3) JC-1 jodide 1h-benzimidazolium, 5,6-dichloro-2[3-(5,6-dichloro-1,3-diethyl-1,3-dihydro-2h-benzimidazol-2-ylidene)-1-propenyl]-1,3-diethyl-, Iodide 5,6-dichloro-2-[3-(5,6-dichloro-1,3-diethyl-2-benzimidazolinylidene)propenyl]-1,3-diethylbenzimidazolium Iodide Benzimidazolium, 5,6-dichloro-2-[3-(5,6-dichloro-1,3diethyl-2-benzimidazolinylidene)propenyl]-1,3-diethyl-, Iodide Benzimidazolocarbocyanine Iodide, 5,50,6,60-tetrachloro-1,10,3,30-tetraethyl- Imidacarbocyanine Iodide, 1,10,3,30-tetraethyl-5,50,6,60-tetrachloro- 1,10,3,30-tetraethyl-5,50,6,60-tetrachlorobenzimidazolocarbocyanine Iodide 1,10,3,30-tetraethyl-5,50,6,60-tetrachloroimidacarbocyanine Iodide 5,50,6,60-tetrachloro-1,10,3,30-tetraethylbenzimidazolocarbocyanine Iodide 5,5',6,6'-TETRACHLORO-1,1',3,3'-*TETRAETHYBENZIMIDA 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethyl-imidacarbocyanine iodide (47729-63-5) 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine iodide CBIC2, >95% JC-1, >95% JC-1 [5,5,6,6-Tetrachloro-1,1,3,3-tetraethylbenzimidazolylcarbocyanine iodide] *CAS#: 3520-43-2* 5,6-dichloro-2-[(E)-3-(5,6-dichloro-1,3-diethylbenzimidazol-3-ium-2-yl)prop-2-enylidene]-1,3-diethylbenzimidazole -tetrachloroimidacarbocyanine iodide ChemicalbookCBIC2,>95% JC-1[5,5,6,6-Tetrachloro-1,1,3,3-tetraethylbenzimidazolylcarbocyanine iodide] JC-1[5,5,6,6-Tetrachloro-1,1,3,3 inhibit,CBIC-2,JC1,CBIC 2,JC 1,JC-1,Inhibitor 3520-43-2 Cyanine