TRIPARANOL
- CAS No.
- 78-41-1
- Chemical Name:
- TRIPARANOL
- Synonyms
- mer29;MER 2p;Clotrox;Diticyl;nsc65345;Drenaren;Metasqua;Acosterina;Metasclene;metasqualene
- CBNumber:
- CB5498433
- Molecular Formula:
- C27H32ClNO2
- Molecular Weight:
- 438
- MDL Number:
- MFCD00865748
- MOL File:
- 78-41-1.mol
Melting point | 102.9-103.7 °C |
---|---|
Density | 1.0173 (rough estimate) |
refractive index | 1.5830 (estimate) |
storage temp. | 2-8°C |
solubility | DMSO: 15 mg/mL |
Boiling point | 235-240 °C(Press: 0.08 Torr) |
pka | 13.44±0.29(Predicted) |
form | solid |
color | off-white |
FDA UNII | 63S8C3RXGS |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS05,GHS07 |
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---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H302-H318 | |||||||||
Precautionary statements | P280-P301+P312+P330-P305+P351+P338+P310 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 22-41 | |||||||||
Safety Statements | 26-39 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | KK2400000 | |||||||||
NFPA 704 |
|
TRIPARANOL price More Price(11)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | T5200 | Triparanol ≥97% (HPLC), powder | 78-41-1 | 5mg | $214 | 2024-03-01 | Buy |
Sigma-Aldrich | T5200 | Triparanol ≥97% (HPLC), powder | 78-41-1 | 25mg | $468.6 | 2024-03-01 | Buy |
Cayman Chemical | 20918 | Triparanol ≥98% | 78-41-1 | 500μg | $54 | 2024-03-01 | Buy |
Cayman Chemical | 20918 | Triparanol ≥98% | 78-41-1 | 1mg | $94 | 2024-03-01 | Buy |
Cayman Chemical | 20918 | Triparanol ≥98% | 78-41-1 | 5mg | $207 | 2024-03-01 | Buy |
TRIPARANOL Chemical Properties,Uses,Production
Originator
Mer-29,Merrell National,US,1960
Uses
Desmosterol Delta 24 (D24) reductase inhibitor
Uses
Triparanol has been used to inhibit cholesterol biosynthesis in lipid rafts1. Triparanol has also been used as a 3β-hydroxysterol-Δ24-reductase inhibitor to study its effect on delayed-rectifier potassium current (Iks) channels2.
Definition
ChEBI: Triparanol is a stilbenoid. It has a role as an anticoronaviral agent.
Manufacturing Process
4-(β-diethylaminoethoxy)-4-methylbenzophenone was prepared as follows: a
mixture of 200 g of 4-hydroxy-4-methylbenzophenone, 55 g of powdered
sodium methoxide and 400 ml of ethanol was stirred for 30 minutes. A
solution of 150 g of β-diethylaminoethyl chloride in 300 ml of toluene was
added and the mixture was refluxed four hours. The solvent was removed, the
residue was taken up in ether, extracted with 5% NaOH solution, twice with
water, the ether was removed and the residue was distilled. The product was
obtained as an oil boiling at 232°C at 0.6 mm.
1 liter of a 0.45 N ethereal solution of p-chlorobenzyl magnesium chloride was
added in 30 minutes to a stirred solution of 104 g (0.35 mol) of 4-(β-
diethylaminoethoxy)-4-methylbenzophenone in 400 ml of dry ether. After
stirring an additional hour, the mixture was decomposed by pouring onto 1
liter of cold 10% ammonium chloride solution, the ether solution was washed
with water, and the ether was replaced with hot isopropanol containing a trace
of ammonia. 1-[p-(β-diethylaminoethoxy)phenyl]-1-phenyl-2-p-tolyl-2-p_x0002_chloroethanol separated as white crystals, melting at 104% to 106°C.
Therapeutic Function
Antihyperlipidemic
Biochem/physiol Actions
Triparanol is known to repress Hedgehog signaling in cancer cells and can also inhibit tumor growth3.
TRIPARANOL Preparation Products And Raw materials
Raw materials
Preparation Products
TRIPARANOL Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Hu Bei Jiutian Bio-medical Technology CO.,Ltd | 027-88013699 17354350817 | Ryan@jiutian-bio.com | China | 7281 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Aikon International Limited | 025-58859352 18068836627 | sales01@aikonchem.com | China | 15085 | 58 |
Shanghai Jizhi Biochemical Technology Co. Ltd. | 400-400-400-9004166 18616739031 | 3007523370@qq.com | China | 52712 | 58 |
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 56086 | 58 |