AG 99
- CAS No.
- 122520-85-8
- Chemical Name:
- AG 99
- Synonyms
- AG 99;(E)-AG 99;TYRPHOSTIN 46;TYRPHOSTIN A46;TYRPHOSTIN B40;AG 99 USP/EP/BP;TYRPHOSTIN AG 99;(E)-AG 99 (AG99);(E)-Tyrphostin 46;TYRPHOSTIN A46 99%
- CBNumber:
- CB5738937
- Molecular Formula:
- C10H8N2O3
- Molecular Weight:
- 204.18
- MDL Number:
- MFCD00133901
- MOL File:
- 122520-85-8.mol
- MSDS File:
- SDS
| Melting point | 247 °C |
|---|---|
| Boiling point | 544.4±50.0 °C(Predicted) |
| Density | 1.482±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in DMSO |
| form | Brown solid. |
| pka | 8.81±0.10(Predicted) |
| FDA UNII | ARL2OF9022 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
AG 99 price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10010313 | AG-99 ≥98% | 122520-85-8 | 5mg | $34 | 2024-03-01 | Buy |
| Cayman Chemical | 10010313 | AG-99 ≥98% | 122520-85-8 | 10mg | $64 | 2024-03-01 | Buy |
| Cayman Chemical | 10010313 | AG-99 ≥98% | 122520-85-8 | 25mg | $150 | 2024-03-01 | Buy |
| Cayman Chemical | 10010313 | AG-99 ≥98% | 122520-85-8 | 50mg | $264 | 2024-03-01 | Buy |
| TRC | A427035 | AG99 | 122520-85-8 | 5mg | $305 | 2021-12-16 | Buy |
AG 99 Chemical Properties,Uses,Production
Uses
Tyrphostin AG 99 is a potent, cell-permeable and reversible inhibitor of EGFR and EGF-dependent cell proliferation.
Biological Activity
Epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 10 μ M) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145 met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro .
References
[1]. gazit a, osherov n, gilon c, et al. tyrphostins. 6. dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of egf receptor tyrosine kinase in vitro. j med chem, 1996, 39(25): 4905-4911.
[2]. yamamoto n, mammadova g, song rx, et al. tyrosine phosphorylation of p145met mediated by egfr and src is required for serum-independent survival of human bladder carcinoma cells. j cell sci, 2006, 119(pt 22): 4623-4633.
AG 99 Preparation Products And Raw materials
Raw materials
Preparation Products
AG 99 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
