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Atomoxetine hydrochloride

Atomoxetine hydrochloride
Atomoxetine hydrochloride structure
CAS No.
82248-59-7
Chemical Name:
Atomoxetine hydrochloride
Synonyms
Strattera;LY 139603;ATOMOXETINE;ATOMOXITINE;LY 139603 HCl;Atazanavir HCl;Atomoxitine HCL;ATOMOXETINE HCL;Atomoxetine HCI;Atomexine Hydrochloride
CBNumber:
CB5757860
Molecular Formula:
C17H22ClNO
Formula Weight:
291.82
MOL File:
82248-59-7.mol

Atomoxetine hydrochloride Properties

Melting point:
167-169°C
alpha 
D25 -38.01°; 36525 -177.26° (c = 1 in methanol); D23 -41.37° (c = 1.02 in methanol); D25 -40.3° (c = 0.94 in ethanol)
Flash point:
9℃
storage temp. 
2-8°C
form 
solid
pka
10.13(at 25℃)
Merck 
14,863
CAS DataBase Reference
82248-59-7(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  F,T
Risk Statements  11-23/24/25-39/23/24/25
Safety Statements  22-24/25-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
HS Code  29221990
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Atomoxetine hydrochloride price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A-095 Atomoxetine hydrochloride solution 82248-59-7 095-1ml $133 2018-11-20 Buy
Sigma-Aldrich 1044469 Atomoxetine hydrochloride United States Pharmacopeia (USP) Reference Standard 82248-59-7 125mg $893 2018-11-13 Buy
TCI Chemical A2357 Atomoxetine Hydrochloride >98.0%(HPLC)(T) 82248-59-7 100mg $91 2018-11-22 Buy
TCI Chemical A2357 Atomoxetine Hydrochloride >98.0%(HPLC)(T) 82248-59-7 1g $522 2018-11-22 Buy
Sigma-Aldrich T7947 (R)-Tomoxetine hydrochloride solid 82248-59-7 50mg $799 2018-11-13 Buy

Atomoxetine hydrochloride Chemical Properties,Uses,Production

Description

Atomoxetine is the first non-stimulant marketed for the treatment of attention deficit hyperactivity disorder (ADHD). It is the R-stereoisomer of the racemate tomoxetine and is a selective and potent norepinephrine uptake inhibitor (Ki=0.7–1.9 nM) that is devoid of binding to monoamine receptor. It also has little effect on dopamine and serotonin reuptake or acetylcholine, H1 histamine, alpha1 or alpha1-adrenergic or dopamine receptors. It is prepared from racemic 1-phenylbut-3-en-1-ol via a selective enzymatic acylation leaving the desired S-stereoisomer as the alcohol. This alcohol is converted via a Mitsunobu reaction with ortho-cresol to the corresponding ether with isomeric R-configuration. Ozonolysis and reduction steps provided the terminal alcohol that is mesylated and displaced with methylamine. Its selectivity for norepinephrine relative to dopamine inhibition was demonstrated in vivo preclinically. In a two-lever (two condition) discriminative stimulus effect study in squirrel monkeys, tomoxetine and other norepinephrine uptake inhibitors substituted for cocaine under low-dose training conditions, whereas dopamine uptake inhibitors substituted for cocaine in both low and high-dose conditions. In clinical ADHD studies in adolescents, it was significantly different from placebo in 1.2 and 1.8 mpk/day dosing. In the clinical study in adults using the CAARS scale a 95 mg/day dose provided greater than 30% improvement in total scores. Atomoxetine is about 63% orally bioavailable, is highly protein bound (98%, primarily to albumin) and has a half-life of about 5.2 h. It is metabolized by CYP2D6 resulting in differential clearance for poor metabolizers (halflife of 19 h with a 10 times higher AUC) relative to extensive metabolizers. The total daily dose for children, adolescents and adults is a maximum of 100 mg/day. Common side effects in children and adults include nausea, decreased appetite, and dizziness. Adults may also have insomnia.

Chemical Properties

White Solid

Originator

Eli Lilly & Co (US)

Uses

A Norepinephrine reuptake inhibitor

Uses

Psychotherapeutic, Anti Depressant

Definition

ChEBI: The hydrochloride salt of atomoxetine.

brand name

Strattera (Lilly).

Biological Activity

Potent and selective noradrenalin re-uptake inhibitor (K i values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). Displays minimal affinity for a range of other neurotransmitter receptors and transporters (K i > 1 μ M). Antidepressant.

Atomoxetine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Atomoxetine hydrochloride Suppliers

Global( 220)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21990 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1530 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24001 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20095 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8409 58
Hebei Chisure Biotechnology Co., Ltd.
+8613292893290
+8613292893290 Nancy@SpeedGainpharma.com CHINA 1020 58

View Lastest Price from Atomoxetine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-01 Atomoxetine hydrochloride
82248-59-7
US $100.00 / KG 1KG 99% Customized career henan chemical co

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