CCT 018159
- CAS No.
- 171009-07-7
- Chemical Name:
- CCT 018159
- Synonyms
- CCT 018159;HSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem;4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol;1,3-Benzenediol, 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-;4-(4-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-5-methyl-1H-pyrazol-3-yl)-6-ethylbenzene-1,3-diol
- CBNumber:
- CB5837186
- Molecular Formula:
- C20H20N2O4
- Molecular Weight:
- 352.38
- MDL Number:
- MFCD00710300
- MOL File:
- 171009-07-7.mol
Boiling point | 547.3±50.0 °C(Predicted) |
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Density | 1.322±0.06 g/cm3(Predicted) |
storage temp. | Store at +4°C |
solubility | ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide |
pka | 8.84±0.48(Predicted) |
form | White solid |
color | White to off-white |
FDA UNII | 55H1ZOI1NL |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H319-H302-H315 | |||||||||
Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
NFPA 704 |
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CCT 018159 price More Price(15)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 385920 | HSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem The HSP90 Inhibitor, CCT018159, also referenced under CAS 171009-07-7, controls the biological activity of HSP90. |
171009-07-7 | 5mg | $230 | 2024-03-01 | Buy |
Cayman Chemical | 10012591 | CCT018159 ≥98% | 171009-07-7 | 1mg | $29 | 2024-03-01 | Buy |
Cayman Chemical | 10012591 | CCT018159 ≥98% | 171009-07-7 | 5mg | $85 | 2024-03-01 | Buy |
Cayman Chemical | 10012591 | CCT018159 ≥98% | 171009-07-7 | 10mg | $156 | 2024-03-01 | Buy |
Cayman Chemical | 10012591 | CCT018159 ≥98% | 171009-07-7 | 50mg | $492 | 2022-04-27 | Buy |
CCT 018159 Chemical Properties,Uses,Production
Uses
CCT 018159 is a cell-permeable compound that inhibits Hsp90 ATPase.
Definition
ChEBI: A member of the class of pyrazoles that is 1H-pyrazole carrying 1,4-benzodioxane-6-yl and 5-ethyl-2,4-dihydroxyphenyl substituents at positions 4 and 5 respectively.
Biological Activity
Novel inhibitor of heat shock protein 90 (Hsp90) ATPase activity (IC 50 = 5.7 μ M) that displays selectivity over human Hsp72 and topoisomerase II. Inhibits proliferation of HCT116 human colon tumor cells and produces upregulation of Hsp70 and downregulation of c-Raf and cdk4. More soluble than 17-AAG (17-Demethoxy-17-(2-propenylamino)geldanamycin ) and is independent of NQO1/DT-diaphorase and P-glycoprotein expression.
in vitro
cct018159 was identified by high-throughput screening inhibiting human hsp90beta with comparable potency to 17-aag and with similar atp-competitive kinetics. x-ray crystallographic structures of the yeast hsp90 complexed with cct018159 showed binding properties similar to radicicol. the mean cellular gi50 of cct018159 across a panel of human cancer cell lines, including melanoma, was 5.3 μm. unlike 17-aag, the in-vitro antitumor activity of cct018159 was independent of nqo1/dt-diaphorase and p-glycoprotein expression. the signature of hsp90 inhibition, comprising increased expression of hsp72 protein and depletion of erbb2, cdk4, c-raf, and mutant b-raf, was indicated in human cancer cell lines treated with cct018159 [1].
in vivo
in human tumor xenografts including skmel 28 melanoma cells, cct018159 was found to induce the expression of hsp72 as well as erbb2, cdk4 and dc-raf [1].
IC 50
3.2 and 6.6 μm for human hsp90β and yeast hsp90, respectively
storage
Store at +4°C
References
[1] s. y. sharp, k. boxall, m. rowlands, et al. in vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. cancer research 67(5), 2206-2216 (2007).
CCT 018159 Preparation Products And Raw materials
Raw materials
Preparation Products
CCT 018159 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
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3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-400-6206333 18521732826 | market@aladdin-e.com | China | 25009 | 65 |
LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 4182 | 55 |
Jinan ponder chemical co. LTD | 0531-0000 | thinklifescience@163.com | China | 19690 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |