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2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)

CAS No.
59989-18-3
Chemical Name:
2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)
Synonyms
GW-776;GW776C85;ADH-300004;NSC 687296;5-ethynyluracil;5-Ethynyluracil>13C,15N2]-Eniluracil;Eniluracil (5-Ethynyluracil;5-Ethynyl-1H-pyrimidine-2,4-dione;5-Ethynyl-2,4(1H,3H)-pyriMidinedione
CBNumber:
CB61081129
Molecular Formula:
C6H4N2O2
Molecular Weight:
136.11
MDL Number:
MFCD00871973
MOL File:
59989-18-3.mol
MSDS File:
SDS
Last updated:2023-09-20 16:43:00

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Properties

Melting point 320° (dec)
Density 1.527
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Soluble in DMSO
form solid
pka 7.44±0.10(Predicted)
color Yellow
λmax 284nm(MeOH)(lit.)
Merck 14,3584
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
FDA UNII 2E2W0W5XIU

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933.59.9500
NFPA 704
0
2 0

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical E1096 5-Ethynyluracil >97.0%(HPLC)(T) 59989-18-3 200mg $201 2024-03-01 Buy
TCI Chemical E1096 5-Ethynyluracil >97.0%(HPLC)(T) 59989-18-3 1g $696 2024-03-01 Buy
TRC E558650 Eniluracil 59989-18-3 10mg $55 2021-12-16 Buy
TRC E558650 Eniluracil 59989-18-3 1g $495 2021-12-16 Buy
American Custom Chemicals Corporation API0005199 ENILURACIL 95.00% 59989-18-3 100MG $779.63 2021-12-16 Buy
Product number Packaging Price Buy
E1096 200mg $201 Buy
E1096 1g $696 Buy
E558650 10mg $55 Buy
E558650 1g $495 Buy
API0005199 100MG $779.63 Buy

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Chemical Properties,Uses,Production

Description

Eniluracil (59989-18-3) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor.1-3? DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).? Eniluracil has been used along with 5-FU to prolong circulating concentrations of the drug.

Uses

Potent inactivator of Dihydropyrimidine dehydrogenase (DPD).

Definition

ChEBI: Eniluracil is a pyrimidone.

References

1) Porter?et al. (1992),?Mechanism-based Inactivation of Dihydropyrimidine Dehydrogenase by 5-Ethynyluracil; J. Biol. Chem.,?267?5236 2) Baccalnari?et al. (1993),?5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil; Proc. Natl. Acad. Sci. USA,?90?11064 3) Schilsky and Kindler (2000)?Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase; Expert Opin. Investig. Drugs,?9?1635

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Suppliers

Global( 63)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715 admin@nexconn.com China 10311 58
Neostar United (Changzhou) Industrial Co., Ltd.
+86-0519-85551759 +8613506123987 marketing1@neostarunited.com China 9305 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30250 58
Labnetwork lnc.
+86-27-50766799 +8618062016861 contact@labnetwork.com China 19994 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Wuhu Nuowei chemistry Co., Ltd.
+86-0553-2911116-802 +undefined17756524438 sales1@nuowei-chem.com China 1640 58
TargetMol Chemicals Inc.
+1-781-999-5354 support@targetmol.com United States 19973 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131980 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Spectrum

5-ethynyluracil 5-Ethynyl-2,4(1H,3H)-pyriMidinedione NSC 687296 GW776C85 ADH-300004 GW-776 5-EthynylpyriMidine-2,4(1H,3H)-dione 5-Ethynyl-1H-pyrimidine-2,4-dione 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) 5-Ethynyluracil> 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- Eniluracil (5-Ethynyluracil 13C,15N2]-Eniluracil 5-fluorouracil,cancer,Inhibitor,inhibit,Eniluracil,5-FU,tumor,combination 59989-18-3 Nucleotides Pharmaceuticals PYRIMIDINE Bases & Related Reagents Intermediates & Fine Chemicals