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ChemicalBook >> CAS DataBase List >>2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Structure
2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) structure
CAS No.
59989-18-3
Chemical Name:
2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)
Synonyms
GW-776;GW776C85;ADH-300004;NSC 687296;5-ethynyluracil;5-Ethynyluracil>13C,15N2]-Eniluracil;Eniluracil (5-Ethynyluracil;5-Ethynyl-1H-pyrimidine-2,4-dione;5-Ethynyl-2,4(1H,3H)-pyriMidinedione
CBNumber:
CB61081129
Molecular Formula:
C6H4N2O2
Molecular Weight:
136.11
MDL Number:
MFCD00871973
MOL File:
59989-18-3.mol
MSDS File:
SDS
Last updated:2023-09-20 16:43:00
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2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Properties

Melting point 320° (dec)
Density 1.527
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Soluble in DMSO
form solid
pka 7.44±0.10(Predicted)
color Yellow
λmax 284nm(MeOH)(lit.)
Merck 14,3584
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
FDA UNII 2E2W0W5XIU

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933.59.9500
NFPA 704
0
2 0

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical E1096 5-Ethynyluracil >97.0%(HPLC)(T) 59989-18-3 200mg $201 2024-03-01 Buy
TCI Chemical E1096 5-Ethynyluracil >97.0%(HPLC)(T) 59989-18-3 1g $696 2024-03-01 Buy
TRC E558650 Eniluracil 59989-18-3 10mg $55 2021-12-16 Buy
TRC E558650 Eniluracil 59989-18-3 1g $495 2021-12-16 Buy
American Custom Chemicals Corporation API0005199 ENILURACIL 95.00% 59989-18-3 100MG $779.63 2021-12-16 Buy
Product number Packaging Price Buy
E1096 200mg $201 Buy
E1096 1g $696 Buy
E558650 10mg $55 Buy
E558650 1g $495 Buy
API0005199 100MG $779.63 Buy

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Chemical Properties,Uses,Production

Description

Eniluracil (59989-18-3) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor.1-3? DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).? Eniluracil has been used along with 5-FU to prolong circulating concentrations of the drug.

Uses

Potent inactivator of Dihydropyrimidine dehydrogenase (DPD).

Definition

ChEBI: Eniluracil is a pyrimidone.

References

1) Porter?et al. (1992),?Mechanism-based Inactivation of Dihydropyrimidine Dehydrogenase by 5-Ethynyluracil; J. Biol. Chem.,?267?5236 2) Baccalnari?et al. (1993),?5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil; Proc. Natl. Acad. Sci. USA,?90?11064 3) Schilsky and Kindler (2000)?Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase; Expert Opin. Investig. Drugs,?9?1635

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Suppliers

Global( 63)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10311 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 +8613506123987 marketing1@neostarunited.com China 9105 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30250 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19994 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Wuhu Nuowei chemistry Co., Ltd. 		+86-0553-2911116-802 +undefined17756524438 sales1@nuowei-chem.com China 1640 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131980 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Supplier Advantage
Shenzhen Nexconn Pharmatechs Ltd 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58
Career Henan Chemica Co 		58
Labnetwork lnc. 		58
InvivoChem 		58
Wuhu Nuowei chemistry Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
J & K SCIENTIFIC LTD. 76

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Spectrum

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)(59989-18-3)1HNMR

59989-18-3(2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI))Related Search:

2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Netivudine CHROMATIDE(TM) TEXAS RED(R)-5-DUTP FLUORESCEIN-12-UTP BIOTIN-11-DDUTP
FLUORESCEIN-12-DUTP DIETHYLAMINOCOUMARIN-5-DUTP FLUORESCEIN CHLOROTRIAZINYL-4-UTP LISSAMINE-5-UTP COUMARIN-5-DDUTP
FLUORESCEIN CHLOROTRIAZINYL-4-DUTP NAPHTHOFLUORESCEIN-5-UTP COUMARIN-5-DUTP CHROMATIDE(TM) TEXAS RED(R)-5-UTP LISSAMINE-5-DUTP
COUMARIN-5-UTP TETRAMETHYLRHODAMINE-6-UTP NAPHTHOFLUORESCEIN-5-DUTP

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5-ethynyluracil 5-Ethynyl-2,4(1H,3H)-pyriMidinedione NSC 687296 GW776C85 ADH-300004 GW-776 5-EthynylpyriMidine-2,4(1H,3H)-dione 5-Ethynyl-1H-pyrimidine-2,4-dione 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) 5-Ethynyluracil> 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- Eniluracil (5-Ethynyluracil 13C,15N2]-Eniluracil 5-fluorouracil,cancer,Inhibitor,inhibit,Eniluracil,5-FU,tumor,combination 59989-18-3 Nucleotides Pharmaceuticals PYRIMIDINE Bases & Related Reagents Intermediates & Fine Chemicals