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Pramlintide

Pramlintide
Pramlintide structure
CAS No.
Chemical Name:
Pramlintide
Synonyms
Pramlintide
CBNumber:
CB61171802
Molecular Formula:
Formula Weight:
0
MOL File:
Mol file

Pramlintide Properties

FDA UNII
D3FM8FA78T

Pramlintide Chemical Properties,Uses,Production

Uses

Antidiabetic.

General Description

Pramlintide is the 25-L-proline-28-L-proline-29-L-prolinetrisubstitution product of human amylin. The marketedformulation (Symlin) is an acetate salt, the exactcomposition of which may not be public-domain knowledge,although salts containing up to four acetic acidmolecules per pramlintide molecule would be possible byvirtue of the free amino terminus andLys1, Arg11, andHis18 residues. The carboxyl terminus of pramlintide, as inamylin, is amidated, and there are no appreciably acidicmoities in the structure; thus, in solution at the pH of bloodand tissues pramlintide would be present almost entirely asone or the other of two significant molecular species, onehaving a +3 charge (histidine imidazole deprotonated anduncharged) predominating modestly over the quadruplyprotonated (+4) species.

Clinical Use

Pramlintide’s effects upon administration to patients almostcertainly arise in significant measure from directAMY-mediated actions within the brainstem. Amylin receptorsare abundant in the circumventricular organs, includingthe subfornical organ (where AMY1(a) receptors areknown to be expressed in relative abundance), the organumvasculosum lateralis terminalis, and the area postrema(AMY3(a)

), where the action of pramlintide (or of -cell–secretedamylin) is not precluded by a diffusional BBB.Amylin receptors are also expressed in various other brainareas, in particular the nucleus accumbens, but neitheramylin or pramlintide circulating in the bloodstream arelikely to exert any action at these BBB-shielded locations.Direct amylin receptor–mediated actions of pramlintide in the periphery, if any, remain poorly characterized.Unsurprisingly, though, the appetite-suppressing actions,and benefits of pramlintide and amylin agonists in general,are receiving significant clinical and scientific attention.

Pramlintide Preparation Products And Raw materials

Raw materials

Preparation Products


Pramlintide Suppliers

Global( 10)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Beijing HuaMeiHuLiBiological Chemical 010-56205725
010-65763397 waley188@sohu.com China 12341 58
Chengdu Youngshe Chemical Co., Ltd. 17380623303 028-62328193-
Caroline@youngshechem.com China 1663 58
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