Thymopentin | 69558-55-0

Thymopentin Properties

Density	1.44±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
pka	3.07±0.10(Predicted)
form	Powder
color	White
Sequence	Arg-Lys-Asp-Val-Tyr
InChIKey	PSWFFKRAVBDQEG-YGQNSOCVSA-N
SMILES	O=C([C@H](CC(O)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)N)=O)=O)N[C@@H](C(C)C)C(N[C@H](C(O)=O)CC1C=CC(=CC=1)O)=O
CAS DataBase Reference	69558-55-0(CAS DataBase Reference)
FDA UNII	O3Y80ZF13F
NCI Drug Dictionary	Immunox
ATC code	L03AX09

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P330-P501

WGK Germany

3

HS Code

3504009000

NFPA 704

	0
2		0

Thymopentin price More Price(64)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T8806	Thymopentin ≥97% (HPLC)	69558-55-0	10mg	$256	2026-04-30	Buy
TCI Chemical	T4310	Thymopentin	69558-55-0	100MG	$213	2026-04-30	Buy
Cayman Chemical	30119	Thymopentin ≥98%	69558-55-0	5mg	$41	2026-04-30	Buy
Cayman Chemical	30119	Thymopentin ≥98%	69558-55-0	10mg	$69	2026-04-30	Buy
Cayman Chemical	30119	Thymopentin ≥98%	69558-55-0	25mg	$140	2026-04-30	Buy

Product number	Packaging	Price	Buy
T8806	10mg	$256	Buy
T4310	100MG	$213	Buy
30119	5mg	$41	Buy
30119	10mg	$69	Buy
30119	25mg	$140	Buy

Thymopentin Chemical Properties, Uses, Production

Description

Thymopentin is a kind of peptide. Peptides and polypeptides play a critical role in the immune system and are therefore predestined as a source for new approaches in immunotherapy. Thymopentin is capable of modulating the immune response. It is a fragment of the thymopoietins (TMPOs) which is a family of nuclear protein. Studies have shown that Thymopentin is capable of affecting the function of T cells and monocytes monitored by increased cGMP level and the triggering of cellular signaling. It is also capable of improve an imbalanced immune system. As an immunomodulating agent, it is clinically used in the treatment of autoimmune diseases such as atopic dermatitis, chronic lymphocytic leukemia, Sezary’s syndrome, rheumatoid arthritis and decreased immune competency. Recent study has also shown that its immuno-modulating effect can also help fight against the infection of mycobacterium tuberculosis.

Chemical Properties

TP is a peptide extracted from calf thymus, and two similar types were found: thymopoietin-I (TP-I) and thymopoietin-II (TP-II).TP-II is a 49 peptide composed of 13 amino acids.The structural difference between TP-I and TP-II is the change of the filament 1 and Su 43 in the peptide chain of TP-II to the Glyc 1 and Group 43 in TP-I. The pentapeptide of Arginine 32-Casein 36 showed the T cell differentiation activity of TP-II both in vivo and ex vivo. 5 of the 49 amino acids are physiologically active. The pentapeptide of arginine 32-tyrosine 36 showed the T-cell differentiation activity of TP-II in vitro and in vivo. 5 out of 49 amino acids were physiologically active, and the pentapeptide of arginine 32-tyrosine valerian 5-peptide, thymopentin, has been synthesized artificially and used in the clinic. In addition, splenin isolated from bovine spleen is similar to TP-II, so it is called TP-III. 5 peptide of synthetic TP-II is tentatively called thymopentin (TPe), and 5 peptide of synthetic TP-III is tentatively called splenic synthesizing protein (SPe). TP-II and TPe act on the neuromuscular transmission to induce the differentiation of T-cell precursor cells in vitro, and inhibit the differentiation of B-cells. TP-III and SPe, on the other hand, induce differentiation of T and B cell precursor cells. Ubiquitin, composed of 74 amino acid residues, induces the differentiation of T and B cells, and is widely found in animal tissues (including thymus) and plant and fungal cells, and is related to immune function.

Originator

Janssen (Belgium)

Uses

Thymopentin Acetate (TP-5) is a synthetic immunomodulating pentapeptide.

Uses

immunoregulator

Definition

ChEBI: Thymopentin is an oligopeptide.

brand name

SINTOMODULINA; TIMUNOX

Clinical Use

Thymopentin is a synthetic, immunomodulating pentapeptide, representing the active fragment of the thymus hormone, thymopoietin. Thymopentin induces phenotypic differentiation and maturation of T-cells. It appears of value in the treatment of primary immune deficiency, rheumatoid arthritis, atopic dermatitis, sarcoidosis and a variety of other diseases with manifestations of disturbed immune balance.

Background

Thymopentin, also known as TP-5, is a synthetic pentapeptide which is the active site of the naturally occurring hormone thymopoietin with immunomodulating properties (corresponding to the amino acids 32-36 of thymopoietin). Thymopentin enhances the production of thymic T cells and may help restore immunocompetence in immunosuppressed subjects. This agent also augments the effects of ionizing radiation by arresting cancer cells in the G2/M phase of the cell cycle.

References

Zhang, Yan, et al. "Novel thymopentin release systems prepared from bioresorbable PLA–PEG–PLA hydrogels." International journal of pharmaceutics 386.1 (2010): 15-22.
Gonser, S., E. Weber, and G. Folkers. "Peptides and polypeptides as modulators of the immune response: thymopentin—an example with unknown mode of action." Pharmaceutica Acta Helvetiae 73.6 (1999): 265-273.
Wang, Ying, et al. "Synthetic modifications of the immunomodulating peptide thymopentin to confer anti-mycobacterial activity." Biomaterials 35.9 (2014): 3102-3109.

Thymopentin Preparation Products And Raw materials

Raw materials

AMBERLITE(R) IRC-50 SEPHADEX G-75 ANION EXCHANGE RESIN 717

Preparation Products

Thymopentin Suppliers

Global Suppliers ( 485)

Supplier	Tel	Email	Country	ProdList	Advantage
ZHEJLANG HUADI PHARMACEUTICAL GROUP CO, LTD.	0571-81061160 18268059989	3343284820@qq.com	China	55	58
Hubei xinghengkang Chemical Technology Co., Ltd	027-88878869 18162384755	969094702@qq.com	China	55	58
ZHEJIANG HUAJUN PHARMACEUTICAL CO., LTD	0571-17315361885 17315361885	15007824@QQ.COM	China	223	58
Nanjing Nor Biotechnology Co., Ltd	17768782665 17768782665	1711908659@qq.com	China	202	58
Sichuan Hantong Kuntai Biotechnology Co., Ltd.	19150383347 19150383347	hantongkuntai@foxmail.com	China	426	58
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2110	70

Supplier	Advantage
ZHEJLANG HUADI PHARMACEUTICAL GROUP CO, LTD.	58
Hubei xinghengkang Chemical Technology Co., Ltd	58
ZHEJIANG HUAJUN PHARMACEUTICAL CO., LTD	58
Nanjing Nor Biotechnology Co., Ltd	58
Sichuan Hantong Kuntai Biotechnology Co., Ltd.	58
INTATRADE GmbH	66
Chembest Research Laboratories Limited	61
GL Biochem (Shanghai) Ltd	64
Pure Chemistry Scientific Inc.	62
LGM Pharma	70

View Latest Price from Thymopentin manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-28	Thymopentin 69558-55-0	1g	98%min	1000g	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-22	Thymopentin 69558-55-0	1g	>=99% (HPLC), USP43	10000000	Chengdu Shengnuo Biopharm Co.,Ltd
2026-09-14	Thymopentin 69558-55-0	2KG	99% up	20tons	Sinoway Industrial co., ltd.

Thymopentin
69558-55-0
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Thymopentin
69558-55-0
>=99% (HPLC), USP43
Chengdu Shengnuo Biopharm Co.,Ltd

Thymopentin
69558-55-0
$0.00
99% up
Sinoway Industrial co., ltd.

Thymopentin Spectrum

Thymopentin(69558-55-0)¹HNMR

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