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ChemicalBook >> CAS DataBase List >>ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate Structure
ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate structure
CAS No.
144927-57-1
Chemical Name:
ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
Synonyms
ethyl 4-chloro-7H-pyrrolo[2;3-d]pyriMidine-5-carboxylate;Ethyl 4-chloro-7H-pyrrolo...;ethyl 4-chloro-1H-pyrrolo[2,3-d]pyrimidine-5-carboxylate;ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate;4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid ethyl ester;7H-Pyrrolo[2,3-d]pyrimidine-5-carboxylic acid, 4-chloro-, ethyl ester
CBNumber:
CB61856192
Molecular Formula:
C9H8ClN3O2
Molecular Weight:
225.63
MDL Number:
MFCD11518913
MOL File:
144927-57-1.mol
MSDS File:
SDS
Last updated:2025-09-25 17:15:13
Product description Number Pack Size Price
Ethyl4-chloro-7h-pyrrolo[2,3-d]pyrimidine-5-carboxylate E903683 100mg $90
Ethyl4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate W3161 250mg $158
Ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate 97.0% 4H58-5-3K 250mg $290
Ethyl 4-chloro-7H-pyrrolo-[2,3-d]pyrimidine-5-carboxylate 95+% 073191 250mg $574
Ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate 97.0% 4H58-5-3K 1g $790
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ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate Properties

Melting point 140-141 °C
Boiling point 320.5±52.0 °C(Predicted)
Density 1.53±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 9.72±0.20(Predicted)
Appearance Off-white to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC E903683 Ethyl4-chloro-7h-pyrrolo[2,3-d]pyrimidine-5-carboxylate 144927-57-1 100mg $90 2021-12-16 Buy
AK Scientific W3161 Ethyl4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate 144927-57-1 250mg $158 2021-12-16 Buy
SynQuest Laboratories 4H58-5-3K Ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate 97.0% 144927-57-1 250mg $290 2021-12-16 Buy
Matrix Scientific 073191 Ethyl 4-chloro-7H-pyrrolo-[2,3-d]pyrimidine-5-carboxylate 95+% 144927-57-1 250mg $574 2021-12-16 Buy
SynQuest Laboratories 4H58-5-3K Ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate 97.0% 144927-57-1 1g $790 2021-12-16 Buy
Product number Packaging Price Buy
E903683 100mg $90 Buy
W3161 250mg $158 Buy
4H58-5-3K 250mg $290 Buy
073191 250mg $574 Buy
4H58-5-3K 1g $790 Buy

ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate Chemical Properties,Uses,Production

Synthesis

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

22276-95-5

Ethyl chloroformate

541-41-3

ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate

144927-57-1

Under nitrogen protection, 5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine (2.00 g, prepared with reference to Example 8 (1)) was dissolved in tetrahydrofuran (50 mL) and cooled to -80°C. A 2.64 M butyl lithium-hexane solution (7.2 mL) was slowly added dropwise, and after completion of the dropwise addition, the reaction mixture was stirred at -80°C for 30 minutes. Subsequently, a tetrahydrofuran (5 mL) solution of ethyl chloroformate (905 μL) was added and the reaction mixture was gradually warmed to room temperature and stirred overnight. Upon completion of the reaction, saturated aqueous ammonium chloride solution was added to the mixture to quench the reaction and the organic phase was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with an eluent ratio of hexane/ethyl acetate (65/35 to 20/80) to afford ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate (1.43 g, 74% yield) as a colorless solid. Mass spectrum (APCI) m/z: 226/228 [M+H]+.

References

[1] Patent: EP2390254, 2011, A1. Location in patent: Page/Page column 67
[2] Journal of Medicinal Chemistry, 2000, vol. 43, # 15, p. 2883 - 2893
[3] Patent: WO2013/85802, 2013, A1. Location in patent: Page/Page column 49-50

ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate Preparation Products And Raw materials

Raw materials

5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine Ethyl chloroformate Ammonium chloride Tetrahydrofuran n-Butyllithium
Hexane

1of2

Preparation Products

ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate Suppliers

Global( 103)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29819 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Chemia Biotechnology（Shanghai） Co., Ltd 		+8613816753574 info@chemia-pharm.com CHINA 311 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52705 58
changzhou huayang technology co., ltd 		+8615250961469 2571773637@qq.com China 9653 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +8618949823763 sales@tnjchem.com China 25356 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 24597 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
career henan chemical co 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Chemia Biotechnology（Shanghai） Co., Ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
changzhou huayang technology co., ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
HANGZHOU LEAP CHEM CO., LTD. 		58

View Lastest Price from ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ethyl 4-chloro-7h-pyrrolo[2,3-d]pyrimidine-5-carboxylate pictures 2022-01-27 Ethyl 4-chloro-7h-pyrrolo[2,3-d]pyrimidine-5-carboxylate
144927-57-1
 US $0.00 / KG 1KG 99.0% 100 tons Honest Joy Holdings Limited
ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate pictures 2019-08-06 ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
144927-57-1
 US $8.80 / KG 1KG 97%-99% 100kg Career Henan Chemical Co

ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate Spectrum

ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate(144927-57-1)1HNMR

144927-57-1(ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate)Related Search:

ethyl 4-hydroxy-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid 5-chloro-3-methylsulfanyl-2,4,9-triazabicyclo[4.3.0]nona-2,4,7,10-tetraene 1H-Pyrrolo[2,3-d]pyrimidine-6-carboxylic acid, 4-chloro-, ethyl ester
ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate 3-d]pyriMidine-5-carboxylate ethyl 4-chloro-7H-pyrrolo[2 Ethyl 4-chloro-7H-pyrrolo... ethyl 4-chloro-1H-pyrrolo[2,3-d]pyrimidine-5-carboxylate 7H-Pyrrolo[2,3-d]pyrimidine-5-carboxylic acid, 4-chloro-, ethyl ester 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid ethyl ester 144927-57-1 CHIRAL CHEMICALS Heterocycle-Pyrimidine series