BW A868C
- CAS No.
- 118675-50-6
- Chemical Name:
- BW A868C
- Synonyms
- BW A868C;(+/-)-3-BENZYL-5-(6-CARBOXYHEXYL)-1-(2-CYCLOHEXYL-2-HYDROXYETHYLAMINO)HYDANTOIN;3-(2-CYCLOHEXYL-2-HYDROXYETHYLAMINO)-2,5-DIOXO-1-BENZYL-4-IMIDAZOLIDINEHEPTANOIC ACID;4-Imidazolidineheptanoic acid, 3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)-;3-[(2-Cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)- 4-imidazolidineheptanoic acid;7-[3-[(2-CYCLOHEXYL-2-HYDROXYETHYL)AMINO]-2,5-DIOXO-1-(PHENYLMETHYL)-4-IMIDAZOLIDINYL]HEPTANOIC ACID
- CBNumber:
- CB6236339
- Molecular Formula:
- C25H37N3O5
- Molecular Weight:
- 459.58
- MDL Number:
- MFCD00877696
- MOL File:
- 118675-50-6.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319-H350 | |||||||||
| Precautionary statements | P201-P202-P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P308+P313-P337+P313-P370+P378-P403+P235-P405-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
BW A868C price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B9180 | BW A868C ≥98% (HPLC) | 118675-50-6 | 5mg | $774 | 2024-03-01 | Buy |
| Cayman Chemical | 12060 | BW A868C ≥98% | 118675-50-6 | 1mg | $87 | 2024-03-01 | Buy |
| Cayman Chemical | 12060 | BW A868C ≥98% | 118675-50-6 | 5mg | $384 | 2024-03-01 | Buy |
| Cayman Chemical | 12060 | BW A868C ≥98% | 118675-50-6 | 10mg | $680 | 2024-03-01 | Buy |
| TRC | B820028 | BW A868C | 118675-50-6 | 1mg | $125 | 2021-12-16 | Buy |
BW A868C Chemical Properties,Uses,Production
Uses
BW A868C is a hydantoin compound structurally related to the DP agonist BW245C.
Definition
ChEBI: BW A868C is an imidazolidine-2,4-dione.
Biological Activity
bw a868c is a novel, selective and potent competitive antagonist of prostaglandin d2 (pgd2) [1].prostaglandin d2 has been widely distributed in rat brain, spinal cord and pituitary and may act as a neuromodulator in the central nervous system [2]. prostaglandin d2 is critical for the development of allergic diseases such as asthma.
in vitro
in glycerol-lysed human platelets, bw245c activated adenylate cyclase in a biphasic manner. bw a868c showed no effect on carbacyclin, iloprost, prostacyclin, pge1 and pge2 at a concentration 1,000 fold that of its kb against pgd2 and bw245c [1]. bw a868c showed no effect on human tp, ip, ep1, ep2, and fp receptors. the ki value for bw a868c is approximately 1.7 nm[1] .in isolated rings of rabbit saphenous vein (rbsv) pre-contracted with 40 mm kcl, bw245c caused concentration-dependent relaxations with an ec50 of 38 nm [3].
References
[1] giles h, leff p, bolofo m l, et al. the classification of prostaglandin dp‐receptors in platelets and vasculature using bw a868c, a novel, selective and potent competitive antagonist[j]. british journal of pharmacology, 1989, 96(2): 291-300.
[2] shimizu t, mizuno n, amano t, et al. prostaglandin d2, a neuromodulator[j]. proceedings of the national academy of sciences, 1979, 76(12): 6231-6234.
[3] lydford s j, mckechnie k c w, leff p. interaction of bw a868c, a prostanoid dp-receptor antagonist, with two receptor subtypes in the rabbit isolated saphenous vein[j]. prostaglandins, 1996, 52(2): 125-139.
BW A868C Preparation Products And Raw materials
Raw materials
Preparation Products
BW A868C Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Hangzhou Synstar pharmaceutical Technology CO.,Ltd | 0571-85361029 | synstar518@163.com | China | 1991 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| amyjetsci | 027-59626688 18771149750 | sales@amyjet.com | China | 3004 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |