Cyclobenzaprine hydrochloride
- CAS No.
- 6202-23-9
- Chemical Name:
- Cyclobenzaprine hydrochloride
- Synonyms
- CYCLOBENZAPRINE HCL;flexeril;Flexiba;Lisseril;flexiban;Cyclobezaprine HCl;MK130 hydrochloride;Nortriptyline EP Impurity E;Amitriptyline EP Impurity B;Cyclobenzaprine HCl (MK130)
- CBNumber:
- CB6238272
- Molecular Formula:
- C20H22ClN
- Molecular Weight:
- 311.85
- MDL Number:
- MFCD00079039
- MOL File:
- 6202-23-9.mol
- MSDS File:
- SDS
Melting point | 216-2180C |
---|---|
Flash point | 9℃ |
storage temp. | Inert atmosphere,Room Temperature |
Water Solubility | Completely soluble in water |
solubility | ≥15.59 mg/mL in DMSO; ≥5.32 mg/mL in EtOH; ≥54.3 mg/mL in H2O |
form | Solid |
color | White to Almost white |
λmax | 290nm(lit.) |
Merck | 14,2713 |
InChIKey | VXEAYBOGHINOKW-UHFFFAOYSA-N |
CAS DataBase Reference | 6202-23-9(CAS DataBase Reference) |
FDA UNII | 0VE05JYS2P |
NCI Drug Dictionary | cyclobenzaprine hydrochloride |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
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Signal word | Danger | |||||||||
Hazard statements | H301-H312+H332 | |||||||||
Precautionary statements | P280-P301+P310+P330-P302+P352+P312-P304+P340+P312 | |||||||||
Hazard Codes | Xn,T,F | |||||||||
Risk Statements | 20/21/22-39/23/24/25-23/24/25-11 | |||||||||
Safety Statements | 36-45-36/37-16-7 | |||||||||
RIDADR | UN 2811 6.1/PG 3 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | HP0875000 | |||||||||
HazardClass | 6.1(b) | |||||||||
PackingGroup | III | |||||||||
HS Code | 29214990 | |||||||||
Toxicity | LD50 in mice (mg/kg): 35 i.v., 250 orally (Metysova) | |||||||||
NFPA 704 |
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Cyclobenzaprine hydrochloride price More Price(29)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | C4542 | Cyclobenzaprine hydrochloride | 6202-23-9 | 1g | $165 | 2024-03-01 | Buy |
Sigma-Aldrich | PHR2797 | Cyclobenzaprine Hydrochloride certified reference material, pharmaceutical secondary standard | 6202-23-9 | 400MG | $280 | 2024-03-01 | Buy |
Sigma-Aldrich | C-060 | Cyclobenzaprine hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? | 6202-23-9 | 1mL | $38.1 | 2024-03-01 | Buy |
TCI Chemical | C3157 | Cyclobenzaprine Hydrochloride >98.0%(HPLC)(T) | 6202-23-9 | 1g | $36 | 2024-03-01 | Buy |
TCI Chemical | C3157 | Cyclobenzaprine Hydrochloride >98.0%(HPLC)(T) | 6202-23-9 | 5g | $104 | 2024-03-01 | Buy |
Cyclobenzaprine hydrochloride Chemical Properties,Uses,Production
Description
Cyclobenzaprine is a skeletal muscle relaxant that also has sedative properties. It has been shown to antagonize muscarinic receptors (Kis = 25, 60, and 6 nM for M1, M2, and M3, respectively), serotonin 5-
Chemical Properties
Crystalline Solid
Originator
Flexeril,Merck Sharp andDohme,US,1977
Uses
Cyclobenzaprine hydrochloride has been used to study its effect on the muscles of dystrophin-deficient mdx5Cv mice.
Uses
Cyclobenzaprine hydrochloride can be used as a serotonin receptor inhibitor.
Uses
Cyclobenzaprine hydrochloride cam be used as muscle relaxant (skeletal).
Definition
ChEBI: The hydrochloride salt of cyclobenzaprine. A centrally acting skeletal muscle relaxant, it is used in the symptomatic treatment of painful muscle spasm.
Manufacturing Process
In an initial step, dibenzo [a,d]cyclohepten-5-one is reacted with the Grignardreagent of 3-dimethylaminopropyl chloride and hydrolyzed to give 5-(3-dimethylaminopropyl)-dibenzo[a,d][1,4]cycloheptatriene-5-ol. Then 13 g ofthat material, 40 ml of hydrochloric acid, and 135 ml of glacial acetic acid isrefluxed for 3? hours. The solution is then evaporated to dryness in vacuoand added to ice water which is then rendered basic by addition of ammoniumhydroxide solution. Extraction of the basic solution with chloroform andremoval of the solvent from the dried chloroform extracts yields the crudeproduct which when distilled in vacuo yields essentially pure 5-(3-dimethylaminopropylidene)-dibenzo[a,d][1,4]cycloheptatriene, BP 173°C to177°C at 1.0 mm.
brand name
Flexeril (McNeil).
Therapeutic Function
Muscle relaxant
General Description
Cyclobenzaprine is a tricyclic agent, which has anti-depressant and anti-cholinergic properties. It lowers the tonic somatic motor activity of motor neuron systems. Cyclobenzaprine prevents the uptake of?noradrenaline. It is used to treat neck,?back and myofascial pain. Cyclobenzaprine functions as a nerve impulse inhibitor.
References
[1]. honda m, nishida t, ono h. tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-ht2 receptors. european journal of pharmacology, 2003, 458(1): 91-99.
[2]. barnes c d, fung s j, gintautas j. brainstem noradrenergic system depression by cyclobenzaprine. neuropharmacology, 1980, 19(2): 221-224.
[3]. leysen j e. 5-ht2 receptors. current drug targets-cns & neurological disorders, 2004, 3(1): 11-26.
Cyclobenzaprine hydrochloride Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Guangzhou Tengyue Chemical Co., Ltd. | +86-86-18148706580 +8618826483838 | evan@tyvovo.com | China | 152 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 906 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
View Lastest Price from Cyclobenzaprine hydrochloride manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-18 | Cyclobenzaprine hydrochloride;Cyclobenzaprine hcl
6202-23-9
|
US $10.00 / KG | 10g | 99% | 1000kg | XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | ||
2024-03-23 | Cyclobenzaprine hydrochloride
6202-23-9
|
US $90.00 / kg | 1kg | 99% Purity (What/sapp: +86 18145728414) | 1000 Tons/Month | Guangzhou Tengyue Chemical Co., Ltd. | ||
2019-07-06 | Cyclobenzaprine hydrochloride
6202-23-9
|
US $1.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
- Cyclobenzaprine hydrochloride;Cyclobenzaprine hcl
6202-23-9
- US $10.00 / KG
- 99%
- XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
- Cyclobenzaprine hydrochloride
6202-23-9
- US $90.00 / kg
- 99% Purity (What/sapp: +86 18145728414)
- Guangzhou Tengyue Chemical Co., Ltd.
- Cyclobenzaprine hydrochloride
6202-23-9
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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