GlyH-101
- CAS No.
- 328541-79-3
- Chemical Name:
- GlyH-101
- Synonyms
- CS-1049;GLYH-101;CFTR Inhibitor II;CFTR Inhibitor II, GlyH-101;CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem;Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor II;GLYH-101;CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR INHIBITOR II;N-2-Naphthalenylglycine [(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide;N-2-NAPHTHALENYL-2-[(3,5-DIBROMO-2,4-DIHYDROXYPHENYL)METHYLENE]GLYCINE HYDRAZIDE;N-2-Naphthalenyl-glycine 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide
- CBNumber:
- CB62446668
- Molecular Formula:
- C19H15Br2N3O3
- Molecular Weight:
- 493.15
- MDL Number:
- MFCD01532954
- MOL File:
- 328541-79-3.mol
- MSDS File:
- SDS
Melting point | >300℃ (ethanol ) |
---|---|
Density | 1.73±0.1 g/cm3(Predicted) |
storage temp. | = -70C |
solubility |
DMF:30.0(Max Conc. mg/mL);60.83(Max Conc. mM) DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.01(Max Conc. mM) DMSO:57.58(Max Conc. mg/mL);116.75(Max Conc. mM) |
form | Yellow solid |
pka | 5.44±0.45(Predicted) |
color | Light yellow to yellow |
GlyH-101 price More Price(21)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 219675 | InSolutionCFTRInhibitorII,GlyH-101-CAS328541-79-3-Calbiochem | 328541-79-3 | 5mg | $230 | 2024-03-01 | Buy |
Sigma-Aldrich | 219671 | CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem CFTR Inhibitor II, GlyH-101, CAS 328541-79-3, is a cell-permeable potent, selective and reversible open-channel blocker of CFTR (Ki = 4.3 μM in CFTR-expressing FRT cells). |
328541-79-3 | 5mg | $216 | 2024-03-01 | Buy |
Cayman Chemical | 15772 | CFTR Inhibitor II ≥95% | 328541-79-3 | 5mg | $41 | 2024-03-01 | Buy |
Cayman Chemical | 15772 | CFTR Inhibitor II ≥95% | 328541-79-3 | 25mg | $142 | 2024-03-01 | Buy |
Cayman Chemical | 15772 | CFTR Inhibitor II ≥95% | 328541-79-3 | 50mg | $263 | 2024-03-01 | Buy |
GlyH-101 Chemical Properties,Uses,Production
Description
The cystic fibrosis (CF) gene encodes a cAMP-
Uses
N-2-Naphthalenyl-glycine 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide is a glycine hydrazide that has recently been shown to block CFTR channels. However, its effects on cardiomyocytes are unknown. Studies have demonstrated that GlyH-101 blocks cardiac I Cl.PKA channels in a similar fashion to that reported for recombinant CFTR.
Definition
ChEBI: Glycine, n-2-naphthalenyl-, 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide is a member of naphthalenes.
General Description
A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50 μM; Ki = 4.3 μM in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl- currents, and is effective in nasal and intestinal epithelia in vivo.
Biochem/physiol Actions
Cell permeable: yes
storage
Store at -20°C
GlyH-101 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29822 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 |
View Lastest Price from GlyH-101 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-12-24 | (NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE
328541-79-3
|
US $1.00 / g | 1g | 99% | 20kg | Career Henan Chemical Co |
- (NAPHTHALEN-2-YLAMINO)-ACETIC ACID (3,5-DIBROMO-2,4-DIHYDROXY-BENZYLIDENE)-HYDRAZIDE
328541-79-3
- US $1.00 / g
- 99%
- Career Henan Chemical Co