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ChemicalBook >> CAS DataBase List >>3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one

3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one

3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one Structure
3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one structure
CAS No.
893422-47-4
Chemical Name:
3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one
Synonyms
Akti_2008;Akt1Akt2-IN-17;Akt1/Akt2-IN-1;Akt1/2 inhibitor 1;Akt1 and Akt2-IN-1;Akt-1 and Akt2-IN-1,Akt1 and Akt2IN1,Akt1 and Akt2 IN 1;3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one;3-phenyl-2-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)-1,6-naphthyridin-5(6H)-one;1,6-Naphthyridin-5(6H)-one, 3-phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-
CBNumber:
CB62473868
Molecular Formula:
C33H29N7O
Molecular Weight:
539.63
MDL Number:
MFCD13184803
MOL File:
893422-47-4.mol
MSDS File:
SDS
Last updated:2023-05-21 10:59:17
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3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one Properties

Density 1.285±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : ≥ 35 mg/mL (64.86 mM)
pka 7.99±0.40(Predicted)

3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-5181 Akt1andAkt2-IN-1 99.17% 893422-47-4 5mg $420 2021-12-16 Buy
ChemScene CS-5181 Akt1andAkt2-IN-1 99.17% 893422-47-4 10mg $600 2021-12-16 Buy
ChemScene CS-5181 Akt1andAkt2-IN-1 99.17% 893422-47-4 50mg $1800 2021-12-16 Buy
ChemScene CS-5181 Akt1andAkt2-IN-1 99.17% 893422-47-4 100mg $2520 2021-12-16 Buy
DC Chemicals DC8695 Akt1andAkt2-IN-1 >98% 893422-47-4 1g $2700 2021-12-16 Buy
Product number Packaging Price Buy
CS-5181 5mg $420 Buy
CS-5181 10mg $600 Buy
CS-5181 50mg $1800 Buy
CS-5181 100mg $2520 Buy
DC8695 1g $2700 Buy

3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one Chemical Properties,Uses,Production

Biological Activity

Akt1 and Akt2-IN-1 are potent allosteric inhibitors, inhibiting Akt1 (IC50=3.5 nM) and Akt2 (IC50=42 nM).

in vitro

Consistent with the allosteric mode of inhibition, Akt1 and Akt2-IN-1 (Compound 17) is dependent on the PH-domain for Akt inhibition, is selective for Akt1/2 over Akt3 (IC 50 =1900 nM), and is highly selective over other members of the AGC family of kinases (>50 μM vs PKA, PKC, SGK). It has moderate activity in an hERG binding assay (IC 50 =5610 nM) and is a substrate for human P-glycoprotein.

in vivo

Akt1 and Akt2-IN-1 (Compound 17) is well tolerated in at exposures that provide high levels of Akt1 and 2 inhibition in vivo. It has also been shown to inhibit the growth of A2780 tumors in vivo when used as monotherapy. Akt1 and Akt2-IN-1 (Compound 17) has potent inhibitory activity against Akt1 and 2 in vivo in a mouse lung and efficacy in a tumor xenograft model. And it shows good pharmacokinetics in rat with a low clearance of 4.6 mL/min/kg and a half-life of 3.8 h.

target

Akt1

3.5 nM (IC 50 )

Akt2

42 nM (IC 50 )

3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one Suppliers

Global( 30)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7553 61
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD 13816107857 sales@fortunechem-sh.com China 289 58
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4863 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3420 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7892 56
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 27322 60
Musechem +1-800-259-7612 info@musechem.com United States 4662 60
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Haoyuan Chemexpress Co., Ltd. 61
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD 58
MedChemexpress LLC 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Shanghai YuanYe Biotechnology Co., Ltd. 60
Musechem 60

893422-47-4(3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one)Related Search:

Phenylimidazole 2-Phenylpyridine Pyridine 2,6-Lutidine
3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one Akti_2008 Akt1 and Akt2-IN-1 3-phenyl-2-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triazol-3-yl)piperidin-1-yl)methyl)phenyl)-1,6-naphthyridin-5(6H)-one Akt1Akt2-IN-17 Akt1/2 inhibitor 1 1,6-Naphthyridin-5(6H)-one, 3-phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]- Akt-1 and Akt2-IN-1,Akt1 and Akt2IN1,Akt1 and Akt2 IN 1 Akt1/Akt2-IN-1 893422-47-4 C33H29N7O