ChemicalBook >> CAS DataBase List >>5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
- CAS No.
- 437655-95-3
- Chemical Name:
- 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
- Synonyms
- Fmoc-PEG4- CH2COOH;Fmoc-NH-PEG5-CH2CO2H;FMoc-NH-PEG4-CH2COOH;Fmoc-NH-PEG4-CH2CO2H;Fmoc-PEG4-acetic acid;Fmoc-N-Amido-PEG4-CH2COOH;5,8,11,14-Tetraoxa-2-azahexadecanedioic acid;1-Hydroxy-1-oxo-5,8,11,14-tetraoxa-2-azahexadecan-16-oic acid;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18-oic acid;14-[(9-Fluorenylmethoxycarbonyl)amino]-3,6,9,12-tetraoxatetradecanoic acid
- CBNumber:
- CB62546849
- Molecular Formula:
- C25H31NO8
- Molecular Weight:
- 473.52
- MDL Number:
- MFCD26142981
- MOL File:
- 437655-95-3.mol
Last updated:2023-04-23 13:52:06
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2942000090 |
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0105401 | Fmoc-NH-PEG4-CH2COOH | 437655-95-3 | 250mg | $100 | 2021-12-16 | Buy |
| Activate Scientific | AS110733 | 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18-oic acid 97% | 437655-95-3 | 250mg | $174 | 2021-12-16 | Buy |
| ChemScene | CS-0105401 | Fmoc-NH-PEG4-CH2COOH | 437655-95-3 | 100mg | $60 | 2021-12-16 | Buy |
| ChemScene | CS-0105401 | Fmoc-NH-PEG4-CH2COOH | 437655-95-3 | 1g | $255 | 2021-12-16 | Buy |
| Activate Scientific | AS110733 | 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azaoctadecan-18-oic acid 97% | 437655-95-3 | 1g | $335 | 2021-12-16 | Buy |
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Chemical Properties,Uses,Production
Description
Fmoc-NH-PEG4-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Biological Activity
Fmoc-NH-PEG4-CH2COOH is a degradable ADC linker for antibody drug conjugate (ADC) synthesis. It is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
target
| Cleavable
| Alkyl/ether
| PEGs
|
5,8,11,14-Tetraoxa-2-azahexadecanedioic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 113)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 9i LLC | +18039569191 | MWan@NiNeiLab.com | United States | 418 | 58 |
| Chengdu Pukang Biotechnology Co., Ltd | 028-82550498 | export@pu-kang.com | CHINA | 210 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2169 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Wuhan Borenpharm Co., Ltd | 027-65563561 18717150066 | 3207347307@qq.com | CHINA | 1238 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3149 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
View Lastest Price from 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-05 | 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
437655-95-3
|
US $1.00 / KG | 1KG | 99% | 1kg-1000kg | Career Henan Chemical Co |
-
- 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
437655-95-3
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
437655-95-3(5,8,11,14-Tetraoxa-2-azahexadecanedioic acid)Related Search:
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5,8,11,14-Tetraoxa-2-azahexadecanedioic acid
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Fmoc-N-Amido-PEG4-CH2COOH
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2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
437655-95-3
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